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Human Polyclonal STAM2 Primary Antibody for ELISA, WB - ABIN251316
Pandey, Fernandez, Steen, Blagoev, Nielsen, Roche, Mann, Lodish: Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. in The Journal of biological chemistry 2001
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Human Polyclonal STAM2 Primary Antibody for IHC, IHC (p) - ABIN4356186
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
The G-102A polymorphism in STAM2 is significantly associated with withers height, heart girth, cannon circumference, chest width, and hip height in Wuchuan Black cattle
SLBP (显示 SLBP 抗体) is a potentially important cellular regulator of HIV-1, thereby establishing a link between histone metabolism, inflammation, and HIV-1 infection
showed that inhibiting the SLBP (显示 SLBP 抗体) mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP (显示 SLBP 抗体) may be mediated via epigenetic mechanisms
Cyclin F (显示 CCNF 抗体)-mediated degradation of SLBP (显示 SLBP 抗体) limits H2A.X (显示 H2AFX 抗体) accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.
CRL4(WDR23 (显示 DCAF11 抗体)) is required for efficient histone mRNA 3' end processing to produce mature histone mRNAs for translation. CRL4(WDR23 (显示 DCAF11 抗体)) binds and ubiquitylates SLBP (显示 SLBP 抗体) in vitro and in vivo, and this modification activates SLBP (显示 SLBP 抗体) function in histone mRNA 3' end processing without affecting its protein levels.
FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (显示 SLBP 抗体).
CRL4-DCAF11 (显示 DCAF11 抗体) mediates the degradation of SLBP (显示 SLBP 抗体) at the end of S phase and this degradation is essential for the viability of cells.
The authors propose a structural organization where the AMSH (显示 STAMBP 抗体)-SH3 binding motif interacts with the STAM2-SH3 domain (显示 ITSN1 抗体) and contributes to the correct positioning of AMSH (显示 STAMBP 抗体) prior to polyubiquitin (显示 UBB 抗体) chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
homologous domain of human Bro1 (显示 HMGCR 抗体) domain-containing proteins, Alix (显示 PDCD6IP 抗体) and Brox, binds CHMP4B (显示 CHMP4A 抗体) but not STAM2, despite their high structural similarity
arsenic, a carcinogenic metal, decreases cellular levels of SLBP (显示 SLBP 抗体) by inducing its proteasomal degradation and inhibiting SLBP (显示 SLBP 抗体) transcription via epigenetic mechanisms
Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
STAM (显示 STAM 抗体) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
SH3 domains of STAM2 and Grb2 (显示 GRB2 抗体) retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein (显示 KLK7 抗体) binding
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
, Hrs-binding protein
, STAM-like protein containing SH3 and ITAM domains 2
, signal transducing adapter molecule 2
, Hrs binding protein
, hrs-binding protein
, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
, EAST protein
, epidermal growth factor receptor-associated protein with SH3 and TAM domain
, signal transducing adaptor molecule 2
, signal transducing adapter molecule 2-like