anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) 抗体产品概述

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anti-Adrenergic, Beta, Receptor Kinase 1 抗体 (ADRBK1)
在www.antibodies-online.cn可供132 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) 抗体的23不同的供货商。 再加上,我们可以发Adrenergic, Beta, Receptor Kinase 1 试剂盒 (22)Adrenergic, Beta, Receptor Kinase 1 蛋白 (11)和数多这个蛋白质的别的产品。 总共180 Adrenergic, Beta, Receptor Kinase 1产品已列进来了。
别名:
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
列出全部抗体 基因 基因ID UniProt
ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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  1. Human Polyclonal ADRBK1 Primary Antibody for IHC (p), WB - ABIN1882061 : Eichmann, Lorenz, Hoffmann, Brockmann, Krasel, Lohse, Quitterer: The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site. in The Journal of biological chemistry 2003 (PubMed)
    Show all 6 references for 1882061

  2. Human Monoclonal ADRBK1 Primary Antibody for ICC, IHC - ABIN969178 : Chen, Long, Wu, Jiang, Ma: EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. in Molecular biology of the cell 2008 (PubMed)
    Show all 2 references for 969178

  3. Human Polyclonal ADRBK1 Primary Antibody for ELISA, WB - ABIN185583 : Iaccarino, Barbato, Cipolletta, De Amicis, Margulies, Leosco, Trimarco, Koch: Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. in European heart journal 2005 (PubMed)

更多抗Adrenergic, Beta, Receptor Kinase 1的相互作用对抗体

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Grk2 rescuing activity requires the integrity of domains essential for its interaction with GPCRs, we speculate that Grk2 may regulate Hh pathway activity by downregulation of a GPCR.

  2. The main novelty presented here is to show that septic shock induces cardiac hyporesponsiveness to isoproterenol by a mechanism dependent on nitric oxide and mediated by G protein-coupled receptor (显示 GPR34 抗体) kinase isoform 2. Therefore, G protein-coupled receptor (显示 GPR34 抗体) kinase isoform 2 inhibition may be a potential therapeutic target in sepsis-induced cardiac dysfunction.

  3. Data, including data from studies in heterozygous knockout mice, suggest that Grk2 is involved in TNFalpha (显示 TNF 抗体)-induced wound healing in epithelial cells of the colon; Grk2 appears to inhibit TNFalpha (显示 TNF 抗体)-induced apoptosis; Grk2 inhibits TNFalpha (显示 TNF 抗体)-induced ERK (显示 EPHB2 抗体) activation by inhibiting generation of reactive oxygen species. Homozygous knockout of Grk2 is embryonically lethal in mice.

  4. GRK2 upregulation causes kappa-opioid receptor (显示 OPRK1 抗体) desensitization in diabetic heart

  5. study provides the first insights into the role of GRK2 in skeletal muscle physiology and points to a role for GRK2 as a modulator of contractile properties in skeletal muscle as well as beta2AR (显示 ADRB2 抗体)-induced hypertrophy.

  6. GRK2 loss confers a protective advantage over control mice after myocardial ischemia/reperfusion injury. Fibroblast GRK2 knockout mice presented with decreased infarct size and preserved cardiac function 24 hours post ischemia/reperfusion. They had decreased fibrosis and fibrotic gene expression. These protective effects correlated with decreased infiltration of neutrophils to the ischemia site and decreased TNF-alpha (显示 TNF 抗体).

  7. this study shows that astragaloside IV alleviates E. coli-caused peritonitis through modulating GRK2-CXCR2 (显示 CXCR2 抗体) signal in neutrophils

  8. GRK2 down-regulation is cardioprotective during diet-induced obesity, reinforcing the protective effect of maintaining low levels of GRK2 under nutritional stress, and showing a role for this kinase in obesity-induced cardiac remodeling and steatosis.

  9. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (显示 GNAQ 抗体)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

  10. GRK2 is localized in the mitochondria and its kinase activity negatively impacts the function of this organelle by increasing superoxide levels and altering substrate utilization for energy production.

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain.

  2. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (显示 GRK4 抗体).

  3. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  4. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  5. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  6. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  7. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit (显示 POLG 抗体) and renders the channels insensitive to inhibition by Nedd4-2 (显示 NEDD4L 抗体).

  8. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  9. Resultrs suggest that activated platelet-derived growth factor receptor-beta (显示 PDGFRB 抗体) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  10. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (显示 OPRM1 抗体)

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. The tyrosine-phosphorylated GRK2 mediates this inhibition by acting on the second intracellular loop of D3R.

  2. GRK2 is overexpressed in pancreatic cancer, and might serve as a potential indicator of unfavorable prognosis.

  3. Data, including data from studies in heterozygous knockout mice, suggest that GRK2 is involved in TNFalpha (显示 TNF 抗体)-induced wound healing in epithelial cells of the colon; GRK2 appears to inhibit TNFalpha (显示 TNF 抗体)-induced apoptosis; GRK2 inhibits TNFalpha (显示 TNF 抗体)-induced ERK (显示 EPHB2 抗体) activation by inhibiting generation of reactive oxygen species. Homozygous knockout of GRK2 is embryonically lethal in mice.

  4. The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.

  5. Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 (显示 HDAC6 抗体) and Pin1 (显示 PIN1 抗体).

  6. GRK2 may inhibit IGF1 (显示 IGF1 抗体)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (显示 EGR1 抗体).

  7. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  8. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  9. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  10. the dual-specific GRK2 and ERK (显示 EPHB2 抗体) cascade inhibitor, RKIP (Raf kinase inhibitor protein (显示 PEBP1 抗体)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (显示 PPARG 抗体)-regulated genes.

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) 抗原简介

Antigen Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497) 抗体
  • adrenergic, beta, receptor kinase 1 (adrbk1) 抗体
  • adrenergic receptor kinase, beta 1 (Adrbk1) 抗体
  • adrenergic, beta, receptor kinase 1 (ADRBK1) 抗体
  • adrenergic, beta, receptor kinase 1 (Adrbk1) 抗体
  • Adrbk-1 抗体
  • Bark-1 抗体
  • BARK1 抗体
  • BETA-ARK1 抗体
  • betaARK1 抗体
  • GRK-2 抗体
  • Grk2 抗体

Protein level used designations for ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

GENE ID SPECIES
10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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