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anti-Prothrombin (F2) 抗体产品概述

Full name:
anti-Coagulation Factor II (thrombin) 抗体 (F2)
在www.antibodies-online.cn可供209 Coagulation Factor II (thrombin) (F2) 抗体的25不同的供货商。 再加上,我们可以发Prothrombin 试剂盒 (120)Prothrombin 蛋白 (52)和数多这个蛋白质的别的产品。 总共389 Prothrombin产品已列进来了。
别名:
AA959438, AI255193, AI327365, C1sa, Cf-2, Cf2, F2, FII, HTRA, HTRA1, prothrombin, PT, RPRGL2, THPH1, thrombin, wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319

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引用最多的anti-Prothrombin 抗体

  1. Human Monoclonal Prothrombin Primary Antibody for WB - ABIN394859 : Ikejiri, Wada, Sakamoto, Ito, Nishioka, Nakatani, Tsuji, Yamada, Nakamura, Ito, Nobori: The association of protein S Tokushima-K196E with a risk of deep vein thrombosis. in International journal of hematology 2010 (PubMed)
    Show all 5 references for ABIN394859

  2. Human Monoclonal Prothrombin Primary Antibody for EIA, WB - ABIN954322 : Kazama, Pastuszyn, Wildgoose, Hamamoto, Kisiel: Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit the tissue factor-enhanced amidolytic activity of factor VIIa. in The Journal of biological chemistry 1993 (PubMed)
    Show all 3 references for ABIN954322

  3. Human Monoclonal Prothrombin Primary Antibody for EIA, WB - ABIN954323 : Bharadwaj, Iino, Kontoyianni, Smith, Foster, Kisiel: Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for ABIN954323

  4. Human Polyclonal Prothrombin Primary Antibody for FACS, SimWes - ABIN4900737 : Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009 (PubMed)

  5. Human Polyclonal Prothrombin Primary Antibody for IHC, ELISA - ABIN1583288 : Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014 (PubMed)

  6. Cow (Bovine) Polyclonal Prothrombin Primary Antibody for IHC, WB - ABIN2776976 : Rossi, Za, Ciminello, Leone, De Stefano: The risk of symptomatic pulmonary embolism due to proximal deep venous thrombosis differs in patients with different types of inherited thrombophilia. in Thrombosis and haemostasis 2008 (PubMed)

更多抗Prothrombin的相互作用对抗体

Zebrafish Coagulation Factor II (thrombin) (F2) interaction partners

  1. Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding

Rhesus Monkey Coagulation Factor II (thrombin) (F2) interaction partners

  1. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

Mouse (Murine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. Biglycan (显示 BGN 抗体) plays a protective role during the progression of atherosclerosis in ApoE (显示 APOE 抗体)-deficient mice by inhibiting thrombin generation.

  2. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (显示 GP1BA 抗体)-binding and heparin-binding site of thrombin

  3. thrombin/PAR-1 (显示 MARK2 抗体) interaction regulated MCP-1 (显示 CPT1B 抗体), TF, MCSF (显示 CSF1 抗体) and IL-6 (显示 IL6 抗体) production.

  4. Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (显示 SERPINC1 抗体) nanoparticle therapeutics.

  5. Thrombin-PAR1 (显示 F2R 抗体) signaling, via nitric oxide and EPCR (显示 PROCR 抗体), promotes hematopoietic stem cell (HSC (显示 FUT1 抗体)) mobilization.

  6. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.

  7. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.

  8. thrombin/PAR1 (显示 F2R 抗体) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.

  9. High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.

  10. Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 (显示 HDAC1 抗体) aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP (显示 COMP 抗体)-thrombin interaction, indicating a 2-site binding mechanism.

Human Coagulation Factor II (thrombin) (F2) interaction partners

  1. Individuals suffering from relapsing-remitting and secondary progressive multiple sclerosis had significantly higher prothrombin and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica patients.

  2. Prothrombin loading of vascular smooth muscle cell-derived exosomes regulates coagulation and calcification.

  3. Case Reports: prothrombin Padua 2 induces antithrombin (显示 SERPINC1 抗体) resistance and is associated with an increased risk of venous thromboembolism. Codon 596 (CGG) of prothrombin is a hot spot for mutations, which constitute a new and relatively frequent cause of inherited thrombophilia.

  4. Thrombin cleavage sites were mapped to the Duffy binding-like delta1 (DBLdelta1) domain and interdomains 1 and 2 in the PfEMP1 of the parasite line IT4var19.

  5. Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix.

  6. Prothrombin uses the intramolecular collapse of kringle-1 onto the active site in the closed form to prevent autoactivation. The open-closed equilibrium also defines a new structural framework for the mechanism of activation of prothrombin by prothrombinase (显示 F10 抗体).

  7. This study demonstrates that impaired EPCR (显示 PROCR 抗体) function can be detected by thrombin generation and clot (显示 TXNDC17 抗体) lysis assays on cells expressing thrombomodulin (显示 THBD 抗体) and EPCR (显示 PROCR 抗体). Deficiency in EPCR (显示 PROCR 抗体) has procoagulant effects that lead to a delay in clot (显示 TXNDC17 抗体) lysis.

  8. Significantly higher serum levels of GP-73 (显示 GOLM1 抗体) and PIVKA-II were detected in the hepatocellular carcinoma patients than in controls.

  9. This study investigated whether type 1 diabetes in children is associated with a hypercoagulable state by performing a global function test of coagulation - the thrombin generation assay. The study found only minor changes of thrombin generation in children and adolescents with type 1 diabetes which - in contrast to type 2 diabetes - do not argue for a hypercoagulable state.

  10. These findings suggest a higher prevalence of prothrombin G20210A in patients with atrial fibrillation when compared to healthy controls.

Cow (Bovine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.

  2. novel pyranosic sulfated (显示 SULF1 抗体) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (显示 SULF1 抗体) polysaccharides and glycosaminoglycans

  3. Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.

  4. the signaling pathways of MAPK (显示 MAPK1 抗体), MSK1 (显示 RPS6KA5 抗体), and NF-kappaB (显示 NFKB1 抗体) play important roles in thrombin-induced iNOS (显示 NOS2 抗体) expression in alveolar macrophages

  5. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.

  6. Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (显示 F2R 抗体)) and thereby increasing the sensitivity of the myofilament to Ca(2 (显示 CA2 抗体)+).

  7. kinetic and structural analysis of interactions between thrombin and the Factor XIII (显示 UGDH 抗体) activation peptide

  8. analysis of staphylocoagulase-mediated bovine prothrombin activation

  9. thrombin and factor Xa (显示 F10 抗体) diffusion along the heparin molecule explains the effects of extended heparin chain lengths

  10. A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

Pig (Porcine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (显示 UGDH 抗体) and by receptor-mediated up-regulation of factor XIII (显示 UGDH 抗体) synthesis

  2. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

  3. In conclusion, thrombin activates pro-MMP-2 (显示 MMP2 抗体) in the absence of elevated pro-MMP-2 (显示 MMP2 抗体) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (显示 MMP2 抗体)

  4. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R 抗体), RhoA (显示 RHOA 抗体), and myocardin (显示 MYOCD 抗体).

Prothrombin (F2) 抗原简介

Antigen Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Alternative names and synonyms associated with Prothrombin (F2)

  • coagulation factor II (thrombin) (f2) 抗体
  • coagulation factor II (thrombin) (F2) 抗体
  • cell division cycle 34 (Cdc34) 抗体
  • chymase 1, mast cell (CMA1) 抗体
  • coagulation factor II (F2) 抗体
  • complement component 1, s subcomponent (C1s) 抗体
  • HtrA serine peptidase 1 (Htra1) 抗体
  • HtrA serine peptidase 2 (HTRA2) 抗体
  • melanoma antigen family B, 17-like (LOC783975) 抗体
  • prothrombin-like (LOC100856539) 抗体
  • serine protease (HTRA) 抗体
  • THROMBIN protein (THROMBIN) 抗体
  • AA959438 抗体
  • AI255193 抗体
  • AI327365 抗体
  • C1sa 抗体
  • Cf-2 抗体
  • Cf2 抗体
  • F2 抗体
  • FII 抗体
  • HTRA 抗体
  • HTRA1 抗体
  • prothrombin 抗体
  • PT 抗体
  • RPRGL2 抗体
  • THPH1 抗体
  • thrombin 抗体
  • wu:fb57c10 抗体
  • wu:fd42e09 抗体
  • wu:fd59d01 抗体
  • zgc:66319 抗体

Protein level used designations for F2

prothrombin , cell division cycle 34 homolog , serine protease , ubiquitin-conjugating enzyme Cdc34 , ubiquitin-conjugating enzyme E2 R1 , alpha-chymase , chymase , mast cell chymase , mast cell protease I , coagulation factor 2 , thrombin , prepro-coagulation factor II , prothrombin B-chain , C1 esterase , complement C1s-A subcomponent , complement component 1 subcomponent s-A , complement component C1SA

GENE ID SPECIES
325881 Danio rerio
712729 Macaca mulatta
299602 Rattus norvegicus
490628 Canis lupus familiaris
14061 Mus musculus
29251 Rattus norvegicus
2147 Homo sapiens
280685 Bos taurus
100144442 Sus scrofa
395306 Gallus gallus
100725988 Cavia porcellus
100307041 Ovis aries
50908 Mus musculus
100716225 Cavia porcellus
395990 Gallus gallus
783975 Bos taurus
100856539 Canis lupus familiaris
100008705 Oryctolagus cuniculus
100009146 Oryctolagus cuniculus
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