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抗Rat (Rattus) Prothrombin 抗体:
抗Mouse (Murine) Prothrombin 抗体:
抗Human Prothrombin 抗体:
Human Monoclonal Prothrombin Primary Antibody for ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. in The American journal of pathology 2010
Show all 2 Pubmed References
Human Polyclonal Prothrombin Primary Antibody for CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009
Human Polyclonal Prothrombin Primary Antibody for IF, WB - ABIN515438
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. in PLoS ONE 2011
Human Polyclonal Prothrombin Primary Antibody for IHC, ELISA - ABIN1583288
Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (显示 BGN 抗体) plays a protective role during the progression of atherosclerosis in ApoE (显示 APOE 抗体)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (显示 GP1BA 抗体)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (显示 MARK2 抗体) interaction regulated MCP-1 (显示 CPT1B 抗体), TF, MCSF (显示 CSF1 抗体) and IL-6 (显示 IL6 抗体) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (显示 SERPINC1 抗体) nanoparticle therapeutics.
Thrombin-PAR1 (显示 F2R 抗体) signaling, via nitric oxide and EPCR (显示 PROCR 抗体), promotes hematopoietic stem cell (HSC (显示 FUT1 抗体)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.
thrombin/PAR1 (显示 F2R 抗体) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
The prevalence of FVL (显示 F5 抗体) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (显示 STXBP1 抗体)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (显示 F5 抗体) mutation with ROP (显示 STXBP1 抗体) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (显示 F10 抗体) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (显示 PROCR 抗体) occupancy recruits G-protein coupled receptor kinase 5 (显示 GRK5 抗体), thereby inducing beta-arrestin-2 (显示 ARRB2 抗体) biased PAR1 (显示 MARK2 抗体) signaling by both APC (显示 APC 抗体) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (显示 F8 抗体) by thrombin has been presented.
These studies clarify the role of PKCdelta (显示 PKCd 抗体) in endothelial cell cytoskeleton regulation.
Findings indicate functional effects of thrombin allostery and suggest that individual active site-directed thrombin inhibitors uniquely modulate exosite function.
Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (显示 SULF1 抗体) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (显示 SULF1 抗体) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (显示 MAPK1 抗体), MSK1 (显示 RPS6KA5 抗体), and NF-kappaB (显示 NFKB1 抗体) play important roles in thrombin-induced iNOS (显示 NOS2 抗体) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (显示 F2R 抗体)) and thereby increasing the sensitivity of the myofilament to Ca(2 (显示 CA2 抗体)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (显示 UGDH 抗体) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (显示 F10 抗体) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (显示 UGDH 抗体) and by receptor-mediated up-regulation of factor XIII (显示 UGDH 抗体) synthesis
In conclusion, thrombin activates pro-MMP-2 (显示 MMP2 抗体) in the absence of elevated pro-MMP-2 (显示 MMP2 抗体) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (显示 MMP2 抗体)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R 抗体), RhoA (显示 RHOA 抗体), and myocardin (显示 MYOCD 抗体).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA