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Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1305113
Matsushima, Oppenheim: Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. in Cytokine 1991
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Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN624491
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN413549
Reeves, Williamson, ONeill, Greally, McElvaney: Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. in American journal of respiratory and critical care medicine 2011
gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC (显示 PSMA7 蛋白) regulation. Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC (显示 PSMA7 蛋白) expansion
Targeted expression of the human oncogene (显示 RAB1A 蛋白) KRASG12V in zebrafish gills induces inflammation and cxcl8-l1 expression.
Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.
results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn (显示 LYN 蛋白) oxidation or indirectly by modulating cxcl8 gene expression
The data identify HOXC9 (显示 HOXC9 蛋白) as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner
Here, we report the characterisation of genes encoding the zebrafish Cxcl8, Cxcr1 (显示 CXCR1 蛋白) and Cxcr2 (显示 CXCR2 蛋白)
this study shows that ponciretin may attenuate ethanol-induced gastritis via the regulation of IL-8 secretion
Adh (显示 AVP 蛋白) binds to OR5M11, which enhances Actinobacillus pleuropneumoniae pathogenicity by activating p38 (显示 CRK 蛋白) which induces apoptosis of PAMs and IL-8 release
Findings suggest that IL8-dependent osteoclast activation may constitute an early event in the initiation of the joint specific inflammation in anti-citrullinated protein-positive rheumatoid arthritis.
Data suggest that CXCL1 (显示 CXCL1 蛋白)/IL-8, released from osteoclasts in an autoantibody-dependent manner, produces pain by activating sensory neurons.
IL-8 signaling is up-regulated in alcoholic hepatitis.
expressions of IL-1beta (显示 IL1B 蛋白) and IL-8 in the brain increased after ApoE (显示 APOE 蛋白) knockout in mice
CYLD (显示 CYLD 蛋白) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via MKP-1 (显示 DUSP1 蛋白)-dependent inhibition of ERK (显示 EPHB2 蛋白).
Taken together, these results indicate that CD147 promotes lung cancer-induced osteoclastogenesis by modulating IL-8 secretion, and suggest that CD147 is a potential therapeutic target for cancer-associated bone resorption in lung cancer patients.
these data outline a novel role for the P2Y6 receptor (显示 P2RY6 蛋白) in the induction of CXCL8/IL-8 production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.
these data suggest that IL-8 plays an important role in breast cancer osteolysis
FOXA1 (显示 FOXA1 蛋白) overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.
gene polymorphisms of IL-8(-251T/A) and IP-10 (显示 CXCL10 蛋白)(-1596C/T) are associated with susceptibility and progression of type 2 diabetic retinopathy in a northern Chinese population
HMGB1 (显示 HMGB1 蛋白) is increased in nasal lavage samples of chronic rhinosinusitis patients; secreted HMGB1 (显示 HMGB1 蛋白) participates in IL-8 upregulation mediating inflammatory response
Recombinant OmpU (rOmpU) of V. cholerae induced IL-8 expression at the mRNA and protein levels in a dose- and time-dependent manner in HT-29 cells. IL-8 was secreted through both apical and basolateral sides of the polarized HT-29 cells upon apical exposure to rOmpU but not upon basolateral exposure.
that the mRNA expression of the chemokine (显示 CCL1 蛋白) IL-8 is significantly lower in samples from interstitial fibrosis/tubular atrophy patients than in samples from patients with stable graft function
Study provides evidence that IL-8 promotor is activated by the binding of RELA (显示 NFkBP65 蛋白) to TWIST1 (显示 TWIST1 蛋白).
In this review, we summarize the biological functions and clinical significance of the CXCL8-CXCR1 (显示 CXCR1 蛋白)/2 signaling pathway in cancer. Targeting CXCL8 or CXCR1 (显示 CXCR1 蛋白)/2 may be an attractive therapeutic strategy for tumors.
IL-8 has a role in lung carcinoma resistance to erlotinib
USP21 (显示 USP21 蛋白) binds to the promoter region of IL-8 and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (显示 MOK 蛋白)
p300 (显示 EP300 蛋白)-dependent histone H3 (显示 HIST3H3 蛋白) acetylation and C/EBPbeta (显示 CEBPB 蛋白)-regulated IKKbeta (显示 IKBKB 蛋白) expression contribute to thrombin (显示 F2 蛋白)-induced IL-8/CXCL8 expression in human lung epithelial cells.
Molecular characterization of the bovine IER3 (显示 IER3 蛋白) gene: Down-regulation of IL-8 by blocking NF-kappaB (显示 NFKB1 蛋白) activity mediated by IER3 (显示 IER3 蛋白) overexpression in MDBK cells infected with bovine viral diarrhea virus-1.
STA3 (显示 ARHGEF3 蛋白) facilitates TLR4 (显示 TLR4 蛋白)-dependent IL-6 (显示 IL6 蛋白) and IL-8 production via IL-6 (显示 IL6 蛋白) receptor-positive feedback in endometrial cells.
As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 (显示 TLR4 蛋白) genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 (显示 TLR4 蛋白) gene may be a potential candidate for such disease.
Blood levels of cortisol, immunoglobulin G, and IL-8 in relationship to genetics and the incidence of bovine respiratory complex disease are reported.
Genetic variation at the IL8 locus explains a proportion of the inter-breed and inter-individual variation in immunity between neonatal calves which is likely to influence their resistance to infection.
In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.
Studied association of IL8 -105G/A with mastitis somatic cell score in Chinese Holstein dairy cows. Results suggest genotype GG may be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein dairy cows.
Data implicate a complex cascade of events during luteolysis, involving Il8 signaling, neutrophil recruitment, and immune cell action within the corpus luteum.
Cadmium exposure induced pulmonary inflammation and increased lung interleukin 8 secretion.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2 (显示 PTGS2 蛋白), and decreased the expression of SOD2 (显示 SOD2 蛋白), GPX3 (显示 GPX3 蛋白), DAB2 (显示 DAB2 蛋白), and NR3C1 (显示 NR3C1 蛋白). TNF (显示 TNF 蛋白) and IL6 (显示 IL6 蛋白) levels were also decreased while those of NAMPT (显示 NAMPT 蛋白) were unaffected.
The JNK (显示 MAPK8 蛋白)-activated AP-1 (显示 JUN 蛋白) subunit c-Jun (显示 JUN 蛋白) was critical for the up-regulation of IL-8 expression by PRRSV
These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88 (显示 MYD88 蛋白)/NF-kappaB (显示 NFKB1 蛋白) signalling pathway.
Facilitated degradation of the RGS16 (显示 RGS16 蛋白) by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (显示 IL6 蛋白) and IL-8 mRNA transcripts.
Suggest that the interplay between TGFbeta (显示 TGFB1 蛋白)-2 and LPS (显示 IRF6 蛋白) regulates the levels of IL-8 in the immature newborn intestine.
Data suggest that MSK1 (显示 RPS6KA5 蛋白) and MSK2 are the major CREB (显示 CREB1 蛋白) kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 (显示 CREB1 蛋白) at Ser (显示 SIGLEC1 蛋白)-133 plays a significant role in IL-8 production.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (显示 IL1B 蛋白), IL-8 and TNF-alpha (显示 TNF 蛋白) in porcine alveolar macrophages.
local expression of IL-1beta (显示 IL1B 蛋白) and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
In swine, IL-8, TNF-ALPHA (显示 TNF 蛋白), INOS (显示 NOS2 蛋白) AND MIP-1BETA (显示 CCL4 蛋白) were increased during mechanical ventilation in a time-related fashion.
Classical swine fever virus NS2 protein promotes interleukin-8 expression.
Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth
At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (显示 CCL2 蛋白)) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
The JNK (显示 MAPK8 蛋白) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha (显示 TNF 蛋白) expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.
IL-8 and IL-1ra (显示 IL1RN 蛋白) showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Results suggested that chemokine (显示 CCL1 蛋白) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
Mapped six genes (EIF4G3 (显示 EIF4G3 蛋白), HSP90 (显示 HSP90AB1 蛋白), RBBP6 (显示 RBBP6 蛋白), IL8, TERT (显示 TERT 蛋白), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
This study examined effects of in vitro exposure to solutions of hay (显示 GTF2H5 蛋白) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
These results suggest that MMP-1 (显示 MMP1 蛋白) and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.
Stress decreased IL-8 gene expression in both CeA (显示 CEACAM3 蛋白) lesioned and non-lesioned animals. But, CeA (显示 CEACAM3 蛋白) lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.
Duck IL-8 is good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
CXC chemokine K60
, interleukin 8
, C-X-C motif chemokine 15
, small inducible cytokine subfamily B, member 15
, small-inducible cytokine B15
, T-cell chemotactic factor
, alveolar macrophage chemotactic factor I
, beta endothelial cell-derived neutrophil activating peptide
, beta-thromboglobulin-like protein
, chemokine (C-X-C motif) ligand 8
, granulocyte chemotactic protein 1
, lung giant cell carcinoma-derived chemotactic protein
, lymphocyte derived neutrophil activating peptide
, monocyte-derived neutrophil chemotactic factor
, monocyte-derived neutrophil-activating peptide
, neutrophil-activating peptide 1
, small inducible cytokine subfamily B, member 8
, tumor necrosis factor-induced gene 1
, C-X-C motif chemokine 8
, neutrophil activating peptide 1
, alveolar macrophage-derived chemotactic factor-I
, neutrophil attractant/activation protein 1
, neutrophil attractant/activation protein-1
, permeability factor 1
, Interleukin-8-like protein
, Neutrophil attractant protein 1
, neutrophil attractant protein-1
, CEF-4/9E3 cytokine
, RSV-induced protein
, embryo fibroblast protein 1
, putatitve interleukin-8
, transformation-induced protein