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Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII.
Ctr9 (显示 CTR9 抗体), a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha (显示 ESR1 抗体)(+) breast tumorigenesis
Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment.
CTR9 (显示 CTR9 抗体) is a PAF1 (显示 PEX2 抗体) complex gene whose germline mutations predispose to Wilms tumour
CTR9 (显示 CTR9 PLURAL_@4401@), a component of PAF (显示 KIAA0101 PLURAL_@4401@) complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF (显示 NELF PLURAL_@4401@) dissociation.
MLL (显示 MLL 抗体) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (显示 PEX2 抗体) and CTR9 (显示 CTR9 抗体). PAFc augments MLL (显示 MLL 抗体) and MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体) mediated transcriptional activation of Hoxa9 (显示 HOXA9 抗体) and their interaction is essential for leukemogenesis.
CTR9 (显示 CTR9 抗体) participates in the transcription of IL-6 (显示 IL6 抗体)-responsive genes through the regulation of DNA association of STAT3 (显示 STAT3 抗体) and modification of histone methylation
CTR9, parafibromin (CDC73\; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
Ctr9, Paf1/RNA polymerase II complex component, homolog
, RNA polymerase-associated protein CTR9 homolog
, SH2 domain binding protein 1 (tetratricopeptide repeat containing)
, SH2 domain-binding protein 1
, TPR-containing, SH2-binding phosphoprotein