anti-XIAP (XIAP) 抗体产品概述

Full name:
anti-X-Linked Inhibitor of Apoptosis 抗体 (XIAP)
在www.antibodies-online.cn可供185 X-Linked Inhibitor of Apoptosis (XIAP) 抗体的29不同的供货商。 再加上,我们可以发XIAP 试剂盒 (19)XIAP 蛋白 (15)和数多这个蛋白质的别的产品。 总共234 XIAP产品已列进来了。
别名:
1110015C02Rik, Aipa, Api3, Birc4, hIAP-3, hIAP3, IAP-3, IAP3, ILP-1, ILP1, MIHA, mXIAP, riap3, XLP2, xxiap

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引用最多的anti-XIAP 抗体

  1. Dog (Canine) Monoclonal XIAP Primary Antibody for IF, IP - ABIN968132 : Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. in The EMBO journal 1996 (PubMed)
    Show all 6 references for 968132

  2. Frog Monoclonal XIAP Primary Antibody for IF, IP - ABIN968163 : Deng, Lin, Wu: TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. in Genes & development 2002 (PubMed)
    Show all 5 references for 968163

  3. Human Polyclonal XIAP Primary Antibody for IF (cc), IF (p) - ABIN674364 : Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. in PLoS ONE 2013 (PubMed)
    Show all 4 references for 674364

  4. Human Polyclonal XIAP Primary Antibody for IHC (p), WB - ABIN3044425 : Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1. in Biochemical and biophysical research communications 2013 (PubMed)
    Show all 3 references for 3044425

  5. Human Polyclonal XIAP Primary Antibody for EIA, IHC (p) - ABIN358604 : Srinivasula, Gupta, Datta, Zhang, Hegde, Cheong, Fernandes-Alnemri, Alnemri: Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for 358604

  6. Human Polyclonal XIAP Primary Antibody for IHC (p), WB - ABIN390070 : Miranda, Dyer, Grandis, Johnson: Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells. in Leukemia 2003 (PubMed)
    Show all 2 references for 390070

更多抗XIAP的相互作用对抗体

Human X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. The authors find that primary human aggressive B-cell lymphoma samples exhibit high USP9X (显示 USP9X 抗体) expression that correlate with XIAP overexpression.

  2. Findings reveal important new insights into how XIAP 3'UTR (显示 UTS2R 抗体) works, suggesting that the non-coding XIAP 3'UTR (显示 UTS2R 抗体) serves as a competitor for miRNA binding and subsequently inactivates miRNA functions, by which XIAP 3'UTR (显示 UTS2R 抗体) frees the target mRNAs from being repressed.

  3. XIAP is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1 (显示 CDK1 抗体)-cyclin-B1 (显示 CCNB1 抗体) at S40.

  4. our findings suggest that X-linked inhibitor of apoptosis protein 3'-untranslated region serves as a competitive endogenous RNA for HMGA2 to activate hepatocellular carcinoma progression by arresting endogenous let-7a-5p.

  5. In chronic myeloid leukemia (显示 BCL11A 抗体) cells, EZH2 (显示 EZH2 抗体) modulates epigenetic changes at DNA methylated regions encoding miR (显示 MLXIP 抗体)-219 and downregulates the level of miR (显示 MLXIP 抗体)-219. Downregulation of miR (显示 MLXIP 抗体)-219 results in upregulation of XIAP and supports the survival of leukemia cells.

  6. IFNgamma positively affects NOD2 (显示 NOD2 抗体)-mediated signaling in human conventional dendritic cells, in a manner considerably dependent on XIAP and partially dependent on mTOR (显示 FRAP1 抗体).

  7. miR (显示 MLXIP 抗体)-137 expression is inversely correlated with the level of XIAP protein in both ovarian cancer tissues and cell lines. these data suggest that multiple miRNAs can regulate XIAP via its 3'UTR (显示 UTS2R 抗体). miR (显示 MLXIP 抗体)-137 can sensitise ovarian cancer cells to cisplatin-induced apoptosis, providing new insight into overcoming drug resistance in ovarian cancer

  8. results of this work support the role of XIAP in mediating NOD2 (显示 NOD2 抗体) signaling while reconciling the role of X-linked lymphoproliferative syndrome 2 and very-early-onset inflammatory bowel disease XIAP mutations in inflammatory cell death and provide a set of tools and framework to rapidly test newly discovered XIAP variants.

  9. Using recombinant proteins, this study investigated the influence of survivin (显示 BIRC5 抗体) on the inhibition of caspase-9 (显示 CASP9 抗体) by XIAP in vitro. With a fluorescence-based assay for the apoptosome-stimulated activity of caspase-9 (显示 CASP9 抗体), the study shows that survivin (显示 BIRC5 抗体) has no effect on the inhibition of caspase-9 (显示 CASP9 抗体) by XIAP, neither in the presence nor in the absence of Smac (显示 DIABLO 抗体).

  10. Study found a negative correlation between Smac (显示 DIABLO 抗体) and XIAP at the level of protein but not mRNA in non-small cell lung carcinoma (NSCLC) patients. Overexpressed XIAP could degrade through ubiquitination, the mature Smac (显示 DIABLO 抗体) inhibiting NSCLC apoptosis.

Mouse (Murine) X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. These results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 (显示 CASP3 抗体) activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.

  2. XIAP antagonizes the switch from TNFalpha (显示 TNF 抗体)-induced apoptosis to necroptosis in mouse neutrophils.

  3. Results show that XIAP binds to the C terminus of Ptch1 (显示 PTCH1 抗体) and mediates the death-dependent function of Ptch1 (显示 PTCH1 抗体).

  4. XIAP modulates ubiquitylation of RIP1 (显示 RALBP1 抗体) and suppresses RIP3 (显示 MPRIP 抗体)-dependent cell death and inflammasome activation in response to TNF (显示 TNF 抗体)-signaling in innate immune cells.

  5. XIAP deficiency selectively impaired B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10 (显示 BCL10 抗体))-mediated innate responses to dectin-1 (显示 CLEC7A 抗体) ligands but did not affect responses to various Toll (显示 TLR4 抗体)-like receptor agonists.

  6. XIAP mRNA level was also reduced in the BRE (显示 BRE 抗体)-depleted cells, but the level of reduction was less profound than that of the protein level. However, BRE (显示 BRE 抗体) could not delay protein turnover of XIAP.

  7. Identify xIAP and cIAP1 (显示 BIRC2 抗体) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.

  8. XIAP-/- DRG sensory neurons degenerate more rapidly and contain more active caspase-3 (显示 CASP3 抗体).

  9. XIAP ubiquitylates RIPK2 (显示 RIPK2 抗体) and recruits the linear ubiquitin chain assembly complex to NOD2 (显示 NOD2 抗体)

  10. XIAP is expressed in oligodendrocytes in vivo and in vitro. Increased XIAP expression is associated with protection against selected cell death pathways, whereas decreased expression increases oligodendroglial cell death.

XIAP 抗原简介

Antigen Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Alternative names and synonyms associated with XIAP

  • X-linked inhibitor of apoptosis (XIAP) 抗体
  • X-linked inhibitor of apoptosis (xiap) 抗体
  • X-linked inhibitor of apoptosis (Xiap) 抗体
  • 1110015C02Rik 抗体
  • Aipa 抗体
  • Api3 抗体
  • Birc4 抗体
  • hIAP-3 抗体
  • hIAP3 抗体
  • IAP-3 抗体
  • IAP3 抗体
  • ILP-1 抗体
  • ILP1 抗体
  • MIHA 抗体
  • mXIAP 抗体
  • riap3 抗体
  • XLP2 抗体
  • xxiap 抗体

Protein level used designations for XIAP

X-linked inhibitor of apoptosis protein , baculoviral IAP repeat-containing 4 , baculoviral IAP-repeat containing protein 4 , Baculoviral IAP repeat-containing protein 4 , E3 ubiquitin-protein ligase XIAP , X-linked IAP , IAP-like protein , baculoviral IAP repeat-containing protein 4 , inhibitor of apoptosis protein 3 , IAP homolog A , IAP-3 , apoptosis inhibitor 3 , mIAP-3 , mIAP3 , RIAP-3 , apoptosis inhibitor protein 3

GENE ID SPECIES
442989 Canis lupus familiaris
594971 Xenopus (Silurana) tropicalis
331 Homo sapiens
11798 Mus musculus
63879 Rattus norvegicus
733235 Xenopus laevis
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