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SMAD6 抗体

SMAD6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5H3 unconjugated
产品编号 ABIN969405
发货至: 中国
  • 抗原 See all SMAD6 抗体
    SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
    适用
    • 51
    • 28
    • 12
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    宿主
    • 54
    • 13
    小鼠
    克隆类型
    • 56
    • 11
    单克隆
    标记
    • 40
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SMAD6 antibody is un-conjugated
    应用范围
    • 58
    • 38
    • 15
    • 12
    • 6
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human SMAD6 expressed in E. coli. ,
    克隆位点
    5H3
    亚型
    IgG1
    Top Product
    Discover our top product SMAD6 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Shintani, Yagi, Nakayama, Saji, Matsuoka: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, (2009) (PubMed).

    Shen, Chen, Wang, Kaneki, Xing, Okeefe, Chen: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, (2006) (PubMed).

    Choi, Lee, Lim, Choi, Lee, Lee, Hong, Kim, Kim, Park: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, (2006) (PubMed).

  • 抗原
    SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
    别名
    SMAD6 (SMAD6 产品)
    别名
    madh6 antibody, madh7 antibody, Xsmad6 antibody, hst17432 antibody, AOVD2 antibody, HsT17432 antibody, MADH6 antibody, MADH7 antibody, Madh6 antibody, b2b390Clo antibody, Smad6-like antibody, smad6 antibody, wu:fb22g05 antibody, SMAD family member 6 antibody, SMAD family member 6a antibody, smad6 antibody, SMAD6 antibody, Smad6 antibody, smad6a antibody
    背景

    Description: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

    Aliases: MADH6, MADH7, HsT17432, SMAD6

    分子量
    53 kDa
    基因ID
    4091
    HGNC
    4091
    途径
    Chromatin Binding
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