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MAP1LC3A 抗体 (C-Term)

This 兔多克隆 antibody specifically detects MAP1LC3A in WB 和 IHC (p). It exhibits reactivity toward 人. It has been mentioned in 12+ publications

Formalin-fixed and paraffin-embedded human testis tissue reacted with Autophagy LC3 antibody (G8b) (C-term) 1802b , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (MAP1LC3A 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (MAP1LC3A 抗体 (C-Term))

IHC (p)

3 images

(12 references)

产品编号 ABIN388474

发货至: 中国

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Quick Overview for MAP1LC3A 抗体 (C-Term) (ABIN388474)

抗原

See all MAP1LC3A 抗体

MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

适用

人

宿主

兔

克隆类型

多克隆

标记

This MAP1LC3A antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB7485

Discover our top product MAP1LC3A Primary Antibody

抗原表位
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AA 77-106, C-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the C-terminal region of human LC3.

亚型

Ig Fraction
anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 89-120), (cleaved) antibody
MAP1LC3A 适用: 人, 小鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal RB38908 unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-30), (N-Term) antibody
MAP1LC3A 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7481 unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-121) antibody
MAP1LC3A 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5B10D8 unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-30), (N-Term) antibody
MAP1LC3A 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7609 unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-120) antibody
MAP1LC3A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-121) antibody
MAP1LC3A 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-30), (N-Term), (pSer12) antibody
MAP1LC3A 适用: 人 WB, DB, EIA 宿主: 兔 Polyclonal unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) antibody
MAP1LC3A 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 166AT1234 unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 30-56) antibody
MAP1LC3A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB11840 unconjugated

anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) antibody
MAP1LC3A 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Eng, Panas, Karlsson Hedestam, McInerney: "A novel quantitative flow cytometry-based assay for autophagy." in: Autophagy, Vol. 6, Issue 5, pp. 634-41, (2012) (PubMed).

Ryu, Kim, Yeo, Kang: "p65/RelA-Ser529 NF-?B subunit phosphorylation induces autophagic astroglial death (Clasmatodendrosis) following status epilepticus." in: Cellular and molecular neurobiology, Vol. 31, Issue 7, pp. 1071-8, (2011) (PubMed).

Li, Wang, Fei, Xia, Qin, Liang: "Parkinson's disease involves autophagy and abnormal distribution of cathepsin L." in: Neuroscience letters, Vol. 489, Issue 1, pp. 62-7, (2011) (PubMed).

Zhuang, Li, Long, Chen, Huang, Liang: "Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy." in: Brain research, Vol. 1371, pp. 7-15, (2011) (PubMed).

Bartlett, Isakson, Lewerenz, Sanchez, Kotzebue, Cumming, Harris, Nezis, Schubert, Simonsen, Finley: "p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects." in: Autophagy, Vol. 7, Issue 6, pp. 572-83, (2011) (PubMed).

Arnold, Cassady, VanLaar, Berman: "Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model." in: Neurobiology of disease, Vol. 41, Issue 1, pp. 189-200, (2010) (PubMed).

Calakos, Patel, Gottron, Wang, Tran-Viet, Brewington, Beyer, Steffens, Krishnan, Züchner: "Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia." in: Journal of medical genetics, Vol. 47, Issue 9, pp. 646-50, (2010) (PubMed).

Cherra, Kulich, Uechi, Balasubramani, Mountzouris, Day, Chu: "Regulation of the autophagy protein LC3 by phosphorylation." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 533-9, (2010) (PubMed).

Yang, Liu, Goga, Kim, Yuneva, Bishop: "Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 31, pp. 13836-41, (2010) (PubMed).

Wang, Gorvel, Chu, Wu, Lei: "Helicobacter pylori impairs murine dendritic cell responses to infection." in: PLoS ONE, Vol. 5, Issue 5, pp. e10844, (2010) (PubMed).

Caramés, Taniguchi, Otsuki, Blanco, Lotz: "Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis." in: Arthritis and rheumatism, Vol. 62, Issue 3, pp. 791-801, (2010) (PubMed).

Ren, He, Nong, Zhu, Hu, Zhang, Huang, Zhu, Wu: "Acquired cisplatin resistance in human lung adenocarcinoma cells is associated with enhanced autophagy." in: Cancer biotherapy & radiopharmaceuticals, Vol. 25, Issue 1, pp. 75-80, (2010) (PubMed).
抗原

MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

别名

LC3

背景

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3b is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

分子量

14688

基因ID

81631

NCBI登录号

NP_073729

UniProt

Q9GZQ8

途径

Autophagy