SLC19A1 抗体 (N-Term)
(2 references)Our Local Distributor
北京 101111
Quick Overview for SLC19A1 抗体 (N-Term) (ABIN310565)
抗原
See all SLC19A1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
序列
- MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
-
预测反应
- Human: 100%
-
产品特性
- This is a rabbit polyclonal antibody against SLC19A1. It was validated on Western Blot and immunohistochemistry.
-
纯化方法
- Protein A purified
-
免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human SLC19A1
-
-
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 412-426), (Extracellular) antibody
SLC19A1 适用: 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (N-Term) antibodySLC19A1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 202-231), (Middle Region) antibodySLC19A1 适用: 小鼠, 大鼠, 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (N-Term) antibodySLC19A1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 101-200) antibodySLC19A1 适用: 小鼠 WB, ICC, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 452-591) antibodySLC19A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 198-231) antibodySLC19A1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
-
说明
-
Antigen size: 591 AA
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
-
: "The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier." in: Molecular pharmacology, Vol. 80, Issue 4, pp. 621-9, (2011) (PubMed).
: "Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 14, pp. 3648-58, (2010) (PubMed).
-
-
- SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1))
-
别名
- SLC19A1
-
背景
-
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. SLC19A1 plays a role in maintaining intracellular concentrations of folate.Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM].
Alias Symbols: CHMD, FOLT, IFC1, REFC, RFC1
Protein Interaction Partner: UBC,
Protein Size: 591 -
分子量
- 65 kDa
-
基因ID
- 6573
-
NCBI登录号
- NM_194255, NP_919231
-
UniProt
- P41440
-
途径
- Dicarboxylic Acid Transport
抗原
-
