anti-PYCARD (PYCARD) 抗体产品概述

在www.antibodies-online.cn可供154 PYD and CARD Domain Containing (PYCARD) 抗体的18不同的供货商。 再加上,我们可以发PYCARD 试剂盒 (8)PYCARD 蛋白 (8)和数多这个蛋白质的别的产品。 总共182 PYCARD产品已列进来了。
9130417A21Rik, Asc, asc1, CARD5, masc, TMS, TMS-1, TMS1, TNS1, zAsc, zgc:109874
列出全部抗体 基因 基因ID UniProt
PYCARD 282817  

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抗Human PYCARD 抗体:

抗Mouse (Murine) PYCARD 抗体:

抗Rat (Rattus) PYCARD 抗体:

所有可销售的anti-PYCARD 抗体



Human PYD and CARD Domain Containing (PYCARD) interaction partners

  1. besides its role in the inhibition of the NF-kappaB (显示 NFKB1 抗体) pathway, NLRC3 (显示 NLRC3 抗体) interferes with the assembly and activity of the NALP3 (显示 NLRP3 抗体) inflammasome complex by competing with ASC for pro-caspase-1 (显示 CASP1 抗体) binding

  2. ASC Induces Apoptosis via Activation of Caspase-9 (显示 CASP9 抗体) by Enhancing Gap Junction-Mediated Intercellular Communication.(

  3. These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.

  4. Down-regulation of mRNA expression was found in cases in which CASP8 (显示 CASP8 抗体), TMS1 (显示 SERINC3 抗体) and DAPK (显示 DAPK1 抗体) were hypermethylated.

  5. loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself

  6. the deubiquitinating enzyme USP50 (显示 USP50 抗体) binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.

  7. ASC self-associates and binds NLRP3 (显示 NLRP3 抗体) PYD through equivalent protein regions, with higher binding affinity for the latter. These regions are located at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD fibril assemblies.

  8. Our data identify RIPK3 (显示 RIPK3 抗体) and the ASC inflammasome as key tumor suppressors in AML (显示 RUNX1 抗体).

  9. The role of the danger signals ASC and HMGB1 (显示 HMGB1 抗体) in the Fusobacterium nucleatum infection of gingival epithelial cells.

  10. Data show that NOD-like receptor signaling genes NOD2 (显示 NOD2 抗体), PYCARD, CARD6 (显示 CARD6 抗体), and IFI16 (显示 IFI16 抗体) are upregulated in psoriatic epidermis.

Mouse (Murine) PYD and CARD Domain Containing (PYCARD) interaction partners

  1. this study shows that ASC (显示 STS 抗体)-dependent Inflammasomes do not shape the commensal gut (显示 GUSB 抗体) microbiota composition

  2. Our data identify RIPK3 (显示 RIPK3 抗体) and the ASC (显示 STS 抗体) inflammasome as key tumor suppressors in AML (显示 RUNX1 抗体).

  3. Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).

  4. Data suggest that interleukin 22 (IL-22 (显示 IL22 抗体)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (显示 STS 抗体))-dependent stimulation of interleukin-1 beta (IL-1beta (显示 IL1B 抗体)) production.

  5. report herein that lack of ASC (显示 STS 抗体) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (显示 STS 抗体)(-/-) mice are capable of producing robust amounts of IL-1beta (显示 IL1B 抗体) comparable with C57BL/6 mice

  6. These data identify a novel non-canonical immunoregulatory function of NLRP3 (显示 NLRP3 抗体) and ASC (显示 STS 抗体) in autoimmunity.

  7. a significant role for NLRP3 (显示 NLRP3 抗体) and ASC (显示 STS 抗体) in prion (显示 PRNP 抗体) pathogenesis

  8. ASC (显示 STS 抗体)-driven caspase-1 (显示 CASP1 抗体) autoprocessing and speck formation are dispensable for the activation of caspase-1 (显示 CASP1 抗体) and the NLRP1b inflammasome.

  9. IKKalpha (显示 CHUK 抗体) controls the inflammasome at the level of the adaptor molecule ASC (显示 STS 抗体), which interacts with IKKalpha (显示 CHUK 抗体) in the nucleus of resting macrophages in an IKKalpha (显示 CHUK 抗体) kinase-dependent manner.

  10. Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (显示 STS 抗体), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.


Antigen Summary

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PYCARD

  • PYD and CARD domain containing (PYCARD) 抗体
  • PYD and CARD domain containing (Pycard) 抗体
  • PYD and CARD domain containing (pycard) 抗体
  • 9130417A21Rik 抗体
  • Asc 抗体
  • asc1 抗体
  • CARD5 抗体
  • masc 抗体
  • TMS 抗体
  • TMS-1 抗体
  • TMS1 抗体
  • TNS1 抗体
  • zAsc 抗体
  • zgc:109874 抗体

Protein level used designations for PYCARD

apoptosis-associated speck-like protein containing a CARD , caspase recruitment domain-containing protein 5 , target of methylation-induced silencing 1 , PYD and CARD domain-containing protein

29108 Homo sapiens
66824 Mus musculus
282817 Rattus norvegicus
282846 Bos taurus
57923 Danio rerio
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