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PAX5 encodes a member of the paired box (PAX) family of transcription factors. 再加上，我们可以发PAX5 蛋白 (7) 和 PAX5 试剂盒 (3)和数多这个蛋白质的别的产品。
Showing 10 out of 243 products:
Human Monoclonal PAX5 Primary Antibody for IHC (p) - ABIN1687422
Steinert, Schenkel, Fraser, Beura, Manlove, Igyártó, Southern, Masopust: Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance. in Cell 2015
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Human Monoclonal PAX5 Primary Antibody for FACS, IHC (p) - ABIN1687411
Zanelli, Valli, Capodanno, Ragazzi, Ascani: Anaplastic lymphoma kinase-positive large B-cell lymphoma: description of a case with an unexpected clinical outcome. in International journal of surgical pathology 2015
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Human Monoclonal PAX5 Primary Antibody for IF, IP - ABIN968219
Adams, Dörfler, Aguzzi, Kozmik, Urbánek, Maurer-Fogy, Busslinger: Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. in Genes & development 1992
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Human Polyclonal PAX5 Primary Antibody for EIA, WB - ABIN954009
Song, Li, Tretiakova, Salgia, Cagle, Husain: Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung. in Archives of pathology & laboratory medicine 2010
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Human Monoclonal PAX5 Primary Antibody for WB - ABIN394437
Okamoto, Ogawa, Nowak, Kawamata, Akagi, Kato, Sanada, Weiss, Haferlach, Dugas, Ruckert, Haferlach, Koeffler: Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. in Haematologica 2010
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Human Polyclonal PAX5 Primary Antibody for WB - ABIN493221
Wallin, Wilting, Koseki, Fritsch, Christ, Balling: The role of Pax-1 in axial skeleton development. in Development (Cambridge, England) 1994
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Human Monoclonal PAX5 Primary Antibody for IHC, ELISA - ABIN1098104
OBrien, Morin, Ouellette, Robichaud: The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease. in Cancer research 2011
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Human Monoclonal PAX5 Primary Antibody for ELISA, WB - ABIN969552
Coyaud, Struski, Prade, Familiades, Eichner, Quelen, Bousquet, Mugneret, Talmant, Pages, Lefebvre, Penther, Lippert, Nadal, Taviaux, Poppe, Luquet, Baranger, Eclache, Radford, Barin, Mozziconacci et al.: Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ... in Blood 2010
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Cow (Bovine) Polyclonal PAX5 Primary Antibody for IHC, WB - ABIN2775953
Robichaud, Nardini, Laflamme, Cuperlovic-Culf, Ouellette: Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells. in The Journal of biological chemistry 2004
These findings suggested that pax5 is critically important for the proliferation and survival of pre-B cells.
a mechanism of transcriptional regulation mediated by p27 (显示 PAK2 抗体), Pax5, and PCAF (显示 KAT2B 抗体)
Data show that paired box gene 5 (B-cell lineage specific activator) protein (Pax-5) induces E-cadherin (显示 CDH1 抗体) expression in breast cancer cells.
a new function of PAX5 in regulating RIP1 (显示 UQCRFS1 抗体) and RIP2 (显示 ARHGEF28 抗体) activation, which is at least involved in chemotherapeutic drug resistance in B-lymphoproliferative disorders, is reported.
PAX5-KIDINS220 (显示 KIDINS220 抗体) fusion is associated with Philadelphia-like acute lymphoblastic leukemia.
this study shows that Pax5 expression is lower in antibody-secreting cells than in naive B cells or plasmablasts
The histological observations suggested that the patients represent diverse cases of NHL (显示 RTEL1 抗体) like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL (显示 RTEL1 抗体). The findings indicate that patients with NHL (显示 RTEL1 抗体) may also be analyzed for status of PAX5, CD19 (显示 CD19 抗体) and ZAP70 (显示 ZAP70 抗体), and their transcriptional and post-translational variants for the differential diagnosis of NHL (显示 RTEL1 抗体) and therapy.
B cell receptor signaling component, SYK (显示 SYK 抗体), caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (显示 PRDM1 抗体) promoter by PAX5 was attenuated by this phosphorylation.
PAX5 haploinsufficiency promotes tumorigenesis and may be related to genomic instability, immune tolerance, and tumor pathways
FISH studies showed false-negative results in 10, 40, and 28% of the samples tested for the IKZF1 (显示 IKZF1 抗体),PAX5, and CDKN2A (显示 CDKN2A 抗体)/B gene deletions, respectively. The PAX5 and IKZF1 (显示 IKZF1 抗体) abnormalities are highly specific to B (显示 TDO2 抗体)-ALL and can be used as diagnostic markers
Pax5 transcription factor cooperates in patterning the Xenopus brain.
identify Pax5 and cyclin D1 (显示 CCND1 抗体) as Zfp521 (显示 ZNF521 抗体) target genes
Together with similar observations made in human PAX5-ETV6 (显示 ETV6 抗体)(+) B-ALLs, these data identified PAX5-ETV6 (显示 ETV6 抗体) fusion as a potent oncoprotein that drives B-cell leukemia development.
PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin (显示 CTNNB1 抗体) pathway and up-regulating GADD45G (显示 GADD45G 抗体) expression.
Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma independent of CCND1 (显示 CCND1 抗体).
Spleen-specific isoform of Pax5 and Ataxin-7 (显示 ATXN7 抗体) can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.
Pax5 and Ebf1 (显示 EBF1 抗体) collaborate to modulate the transcriptional response to Notch (显示 NOTCH1 抗体) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.
a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 (显示 EBF1 抗体) and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins
These results show that in contrast to simple Pax5 haploinsufficiency, multiple sequential alterations targeting lymphoid development are central to leukemogenesis and contribute to the arrest in lymphoid maturation characteristic of ALL.
miR (显示 MLXIP 抗体)-155 inhibits PU.1 expression, leading to Pax5 down-regulation and the initiation of the plasma cell differentiation pathway.
restoring endogenous Pax5 expression in established B-ALL triggers immunophenotypic maturation and durable disease remission by engaging a transcriptional program reminiscent of normal B-cell differentiation
pax5 works in conjunction with fgf3 (显示 FGF3 抗体) and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function.
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
paired box 5
, paired box gene 5 (B-cell lineage specific activator)
, paired box protein Pax-5
, paired box protein Pax-5-like
, B-cell lineage specific activator
, paired box homeotic gene 5
, paired domain gene 5
, transcription factor PAX 5
, B-cell-specific transcription factor
, Pax5 variant 1
, Pax5 variant 2
, No isthmus protein