anti-Paired Box 5 (PAX5) 抗体

PAX5 encodes a member of the paired box (PAX) family of transcription factors. 再加上,我们可以发PAX5 蛋白 (7)PAX5 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PAX5 5079 Q02548
PAX5 500453  
PAX5 18507 Q02650
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Showing 10 out of 254 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB <b>WB Suggested Anti-PAX5 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2至3个工作日
非结合性 EIA, WB PAX5 Antibody (Center) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. PAX5 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PAX5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6至8个工作日
非结合性 IHC (p) Flow cytometric analysis of rabbit anti-PAX-5 (SP34) antibody in RAMOS (green) compare to negative control of rabbit IgG (blue). 7 mL Log in to see 2至3个工作日
非结合性 FACS, IHC (p) Flow cytometric analysis of rabbit anti-PAX-5 (SP34) antibody in RAMOS (green) compare to negative control of rabbit IgG (blue). 1 mL Log in to see 2至3个工作日
小鼠 非结合性 IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10 ng), Green: Antigen (50ng), Blue: Antigen (100 ng) Figure 2: Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining. 100 μg Log in to see 2至3个工作日
小鼠 非结合性 ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Western blot analysis using PAX5 mouse mAb against Raji (1), and EVC-304 (2) cell lysate. 100 μg Log in to see 2至3个工作日
小鼠 非结合性 IF, IP, IHC, WB Western blot analysis of Pax-5 on mouse spleen. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-Pax-5 antibody. Immunofluorescent staining on SW-13 cells. 50 μg Log in to see 6至8个工作日
山羊 非结合性 ELISA, WB ABIN184804 staining (3µg/ml) of U937 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6至7个工作日
小鼠 非结合性 WB Western blot analysis of PAX5 over-expressed 293 cell line, cotransfected with PAX5 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of PAX5 expression in transfected 293T cell line by PAX5 monoclonal antibody (M01), clone 8F9. Lane 1: PAX5 transfected lysate(42.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8至11个工作日
非结合性 ELISA, WB Western blot analysis of extracts from 293 cells, using Pax-5 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日

通过反应活性、应用领域、克隆类型和共轭标记 PAX5 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-PAX5 抗体

  1. Human Monoclonal PAX5 Primary Antibody for IHC (p) - ABIN1687422 : Steinert, Schenkel, Fraser, Beura, Manlove, Igyártó, Southern, Masopust: Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance. in Cell 2015 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal PAX5 Primary Antibody for FACS, IHC (p) - ABIN1687411 : Zanelli, Valli, Capodanno, Ragazzi, Ascani: Anaplastic lymphoma kinase-positive large B-cell lymphoma: description of a case with an unexpected clinical outcome. in International journal of surgical pathology 2015 (PubMed)
    Show all 7 Pubmed References

  3. Human Monoclonal PAX5 Primary Antibody for IF, IP - ABIN968220 : Adams, Dörfler, Aguzzi, Kozmik, Urbánek, Maurer-Fogy, Busslinger: Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. in Genes & development 1992 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal PAX5 Primary Antibody for IF, IP - ABIN968219 : Foss, Reusch, Demel, Lenz, Anagnostopoulos, Hummel, Stein: Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin. in Blood 1999 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal PAX5 Primary Antibody for IHC, ELISA - ABIN1098104 : OBrien, Morin, Ouellette, Robichaud: The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease. in Cancer research 2011 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal PAX5 Primary Antibody for ELISA, WB - ABIN969552 : Coyaud, Struski, Prade, Familiades, Eichner, Quelen, Bousquet, Mugneret, Talmant, Pages, Lefebvre, Penther, Lippert, Nadal, Taviaux, Poppe, Luquet, Baranger, Eclache, Radford, Barin, Mozziconacci et al.: Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ... in Blood 2010 (PubMed)
    Show all 2 Pubmed References


Human Paired Box 5 (PAX5) interaction partners

  1. These findings suggested that pax5 is critically important for the proliferation and survival of pre-B cells.

  2. a mechanism of transcriptional regulation mediated by p27 (显示 PAK2 抗体), Pax5, and PCAF (显示 KAT2B 抗体)

  3. Data show that paired box gene 5 (B-cell lineage specific activator) protein (Pax-5) induces E-cadherin (显示 CDH1 抗体) expression in breast cancer cells.

  4. a new function of PAX5 in regulating RIP1 (显示 UQCRFS1 抗体) and RIP2 (显示 ARHGEF28 抗体) activation, which is at least involved in chemotherapeutic drug resistance in B-lymphoproliferative disorders, is reported.

  5. PAX5-KIDINS220 (显示 KIDINS220 抗体) fusion is associated with Philadelphia-like acute lymphoblastic leukemia.

  6. this study shows that Pax5 expression is lower in antibody-secreting cells than in naive B cells or plasmablasts

  7. The histological observations suggested that the patients represent diverse cases of NHL (显示 RTEL1 抗体) like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL (显示 RTEL1 抗体). The findings indicate that patients with NHL (显示 RTEL1 抗体) may also be analyzed for status of PAX5, CD19 (显示 CD19 抗体) and ZAP70 (显示 ZAP70 抗体), and their transcriptional and post-translational variants for the differential diagnosis of NHL (显示 RTEL1 抗体) and therapy.

  8. B cell receptor signaling component, SYK (显示 SYK 抗体), caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (显示 PRDM1 抗体) promoter by PAX5 was attenuated by this phosphorylation.

  9. PAX5 haploinsufficiency promotes tumorigenesis and may be related to genomic instability, immune tolerance, and tumor pathways

  10. FISH studies showed false-negative results in 10, 40, and 28% of the samples tested for the IKZF1 (显示 IKZF1 抗体),PAX5, and CDKN2A (显示 CDKN2A 抗体)/B gene deletions, respectively. The PAX5 and IKZF1 (显示 IKZF1 抗体) abnormalities are highly specific to B (显示 TDO2 抗体)-ALL and can be used as diagnostic markers

Xenopus laevis Paired Box 5 (PAX5) interaction partners

  1. Pax5 transcription factor cooperates in patterning the Xenopus brain.

Mouse (Murine) Paired Box 5 (PAX5) interaction partners

  1. identify Pax5 and cyclin D1 (显示 CCND1 抗体) as Zfp521 (显示 ZNF521 抗体) target genes

  2. Together with similar observations made in human PAX5-ETV6 (显示 ETV6 抗体)(+) B-ALLs, these data identified PAX5-ETV6 (显示 ETV6 抗体) fusion as a potent oncoprotein that drives B-cell leukemia development.

  3. PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin (显示 CTNNB1 抗体) pathway and up-regulating GADD45G (显示 GADD45G 抗体) expression.

  4. Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma independent of CCND1 (显示 CCND1 抗体).

  5. Spleen-specific isoform of Pax5 and Ataxin-7 (显示 ATXN7 抗体) can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.

  6. Pax5 and Ebf1 (显示 EBF1 抗体) collaborate to modulate the transcriptional response to Notch (显示 NOTCH1 抗体) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.

  7. a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 (显示 EBF1 抗体) and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins

  8. These results show that in contrast to simple Pax5 haploinsufficiency, multiple sequential alterations targeting lymphoid development are central to leukemogenesis and contribute to the arrest in lymphoid maturation characteristic of ALL.

  9. miR (显示 MLXIP 抗体)-155 inhibits PU.1 expression, leading to Pax5 down-regulation and the initiation of the plasma cell differentiation pathway.

  10. restoring endogenous Pax5 expression in established B-ALL triggers immunophenotypic maturation and durable disease remission by engaging a transcriptional program reminiscent of normal B-cell differentiation

Zebrafish Paired Box 5 (PAX5) interaction partners

  1. pax5 works in conjunction with fgf3 (显示 FGF3 抗体) and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function.

PAX5 抗原简介


This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Gene names and symbols associated with anti-Paired Box 5 (PAX5) 抗体

  • paired box 5 (PAX5) 抗体
  • paired box 5 L homeolog (pax5.L) 抗体
  • paired box 5 (Pax5) 抗体
  • paired box 5 (pax5) 抗体
  • BSAP 抗体
  • EBB-1 抗体
  • KLP 抗体
  • noi 抗体
  • Pax-5 抗体
  • pax2.1 抗体
  • pax2a 抗体
  • PAX5 抗体
  • pax5-a 抗体
  • paxzf-b 抗体
  • Pax[Zf-b] 抗体
  • RGD1565236 抗体

Protein level used designations for anti-Paired Box 5 (PAX5) 抗体

paired box 5 , paired box gene 5 (B-cell lineage specific activator) , paired box protein Pax-5 , paired box protein Pax-5-like , B-cell lineage specific activator , paired box homeotic gene 5 , paired domain gene 5 , transcription factor PAX 5 , XPax-5 , B-cell-specific transcription factor , Pax5 variant 1 , Pax5 variant 2 , No isthmus protein

716839 Macaca mulatta
747452 Pan troglodytes
100055252 Equus caballus
100389113 Callithrix jacchus
100457719 Pongo abelii
100481668 Ailuropoda melanoleuca
100586040 Nomascus leucogenys
5079 Homo sapiens
378499 Xenopus laevis
387330 Gallus gallus
612021 Canis lupus familiaris
500453 Rattus norvegicus
100520167 Sus scrofa
538371 Bos taurus
18507 Mus musculus
60636 Danio rerio
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