anti-Left-Right Determination Factor 2 (LEFTY2) 抗体

LEFTY2 encodes a member of the TGF-beta family of proteins. 再加上,我们可以发LEFTY2 蛋白 (11)LEFTY2 试剂盒 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
LEFTY2 13590 Q64280
LEFTY2 7044 O00292
LEFTY2 289316  
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB <b>WB Suggested Anti-LEFTY2 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>RPMI 8226 cell lysate Immunohistochemistry with Uterus tissue at an antibody concentration of 5µg/ml using anti-LEFTY2 antibody (ARP42107_P050) 100 μL Log in to see 2至3个工作日
小鼠 非结合性 EIA, IHC (p), WB   0.1 mg Log in to see 12至15个工作日
非结合性 WB 100 μL Log in to see 2至3个工作日
非结合性 IHC (p), WB Anti-LEFTY2 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959060 concentration 5 ug/ml. 50 μg Log in to see 7至9个工作日
非结合性 WB Western blot analysis of extracts of various cells, using LEFTY2 antibody. 100 μL Log in to see 16 Days
非结合性 IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 10% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using LEFTY2, antibody at 1:500 dilution. 100 μL Log in to see 1至2个工作日
小鼠 非结合性 ICC, IHC, IP, WB Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Log in to see 15至18个工作日
小鼠 非结合性 IHC, ELISA, WB 0.05 mg Log in to see 2至3个工作日
小鼠 非结合性 IHC (p), ELISA, WB 50 μg Log in to see 6至7个工作日
非结合性 ELISA, WB 50 μg Log in to see 2至3个工作日

通过反应活性、应用领域、克隆类型和共轭标记 LEFTY2 抗体

特性 应用范围 宿主 克隆类型 标记
Mouse (Murine) ,
, , ,
Human ,
Rat (Rattus) ,


Zebrafish Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  2. we find that Cyclops is specifically required for the maintenance of lefty1 (显示 LEFTY1 抗体) and lefty2 transcription

  3. study reports that microRNA-430 (miR (显示 MYLIP 抗体)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (显示 TGFB1 抗体) Nodal antagonist lefty

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (显示 DNMT3A 抗体) and DNMT3B (显示 DNMT3B 抗体); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (显示 HELLS 抗体) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  2. LEFTY2 regulates the expression and activity of ENaC (显示 SCNN1A 抗体) in endometrial epithelial cells via SGK1 (显示 SGK1 抗体).

  3. Results indicate that microRNA miR (显示 MLXIP 抗体)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).

  4. exogenous lefty1 (显示 LEFTY1 抗体) administered to mice restored the endogenous expression levels of lefty1 (显示 LEFTY1 抗体). The present study demonstrated that lefty1 (显示 LEFTY1 抗体) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (显示 TGFB1 抗体) signaling pathway

  5. Lefty-1 (显示 LEFTY1 抗体) may prevent TGFB1 (显示 TGFB1 抗体)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (显示 SMAD3 抗体), JNK-3 (显示 MAPK10 抗体), and BMP-5 (显示 BMP5 抗体) signaling.

  6. The expression of lefty in RCC (显示 XRCC1 抗体) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (显示 XRCC1 抗体).

  7. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.

  8. Taken together, these results suggest that optimal expression of Lefty1 (显示 LEFTY1 抗体) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

  9. Beta-catenin (显示 CTNNB1 抗体) can recruit the H3K4me2/1 demethylase (显示 MBD2 抗体) LSD1 (显示 KDM1A 抗体) to regulate the expression of the tumor suppressor Lefty1 (显示 LEFTY1 抗体) in mouse embryonic stem cells.

  10. Lefty can antagonise TGF-beta1 (显示 TGFB1 抗体) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

Human Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. LEFTY2 down-regulates MKi67 (显示 MKI67 抗体) expression and FAK (显示 PTK2 抗体) activity, up-regulates miR (显示 MLXIP 抗体)-200a and E-cadherin (显示 CDH1 抗体), and is thus a powerful negative regulator of endometrial cell proliferation and migration.

  2. LEFTY2 regulates the expression and activity of ENaC (显示 SCNN1A 抗体) in endometrial epithelial cells via SGK1 (显示 SGK1 抗体).

  3. Lefty A may account for the tumor suppressive activity of human adult stem cells.

  4. Findings suggest that Lefty2 is negatively modulated by miR (显示 MLXIP 抗体)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  5. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression

  6. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells

  7. Addition of recombinant LEFTY-A to explants induced MMP-9 (显示 MMP9 抗体) in most samples, a response prevented by ovarian steroids.

  8. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

LEFTY2 抗原简介


This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with LEFTY2

  • lefty2 (lft2) 抗体
  • left-right determination factor 2 (LEFTY2) 抗体
  • left-right determination factor 1 (LOC490387) 抗体
  • left-right determination factor 2 (LOC699676) 抗体
  • left-right determination factor 2-like (LOC100232580) 抗体
  • left right determination factor 1 (Lefty1) 抗体
  • left-right determination factor 2 (Lefty2) 抗体
  • Left-right determination factor 2 (Lefty2) 抗体
  • 6030463A22Rik 抗体
  • AI450052 抗体
  • atv2 抗体
  • AV214969 抗体
  • cb720 抗体
  • EBAF 抗体
  • Ebaf2 抗体
  • fe38b03 抗体
  • Lefta 抗体
  • Leftb 抗体
  • lefty 抗体
  • lefty-1 抗体
  • LEFTY1 抗体
  • LEFTYA 抗体
  • Stra3 抗体
  • TGFB4 抗体
  • wu:fe38b03 抗体

Protein level used designations for LEFTY2

lefty , endometrial bleeding associated factor , left-right determination factor 1 , left-right determination factor 2 , left-right determination factor 2-like , TGF-beta-4 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , transforming growth factor beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , left-right determination factor B , left-right determination, factor A , protein lefty-B

30146 Danio rerio
395529 Gallus gallus
457780 Pan troglodytes
490387 Canis lupus familiaris
699676 Macaca mulatta
100232580 Taeniopygia guttata
100435327 Pongo abelii
13590 Mus musculus
7044 Homo sapiens
320202 Mus musculus
289316 Rattus norvegicus
100337677 Sus scrofa
534018 Bos taurus
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