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The protein encoded by KRT13 is a member of the keratin gene family.
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Human Monoclonal KRT13 Primary Antibody for IHC (fro), IHC - ABIN335223
Kopan, Traska, Fuchs: Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. in The Journal of cell biology 1987
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Human Monoclonal KRT13 Primary Antibody for IHC (fro), IHC - ABIN335215
Bauwens, De Groot, Ramaekers, Veldman, Huizing: Expression of intermediate filament proteins in the adult human vestibular labyrinth. in The Annals of otology, rhinology, and laryngology 1992
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Human Monoclonal KRT13 Primary Antibody for IHC (fro), IHC (p) - ABIN335313
Dallenbach-Hellweg, Lang: Immunohistochemical studies on uterine tumors. I. Invasive squamous cell carcinomas of the cervix and their precursors. in Pathology, research and practice 1991
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Four rare missense variants were identified (ACTBL2 (显示 ACTBL2 抗体) rs73757391 (5q11.2), BTD (显示 BTD 抗体) rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R (显示 MC2R 抗体) rs104894658 (18p11.21)), but only MC2R (显示 MC2R 抗体) rs104894668 had a large effect size (OR = 9.66).
KRT13 expression is associated with poor prognosis at multiple stages of disease progression
Loss of CK13 expression is associated with invasive oral squamous cell carcinoma.
Low KRT13 mRNA expression is associated with oral squamous cell carcinoma.
Decreased KRT13 was associated with Esophageal Squamous Cell Carcinoma.
Our data provide mechanistic insights into the epigenetic silencing of KRT13 genes in OSCC cells and might be useful for the development of diagnostic markers and novel therapeutic approaches against OSCCs.
The immunofluorescent staining pattern of Wnt1 (显示 WNT1 抗体) and CK7 (显示 KRT7 抗体) as well as Wnt1 (显示 WNT1 抗体) and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt (显示 WNT2 抗体) is involved in tumor cell differentiation of peripheral columnar cells forming solid nests
Immunoexpression of CK13 and CK17 (显示 KRT17 抗体) in light green-stained superficial cells was associated with more severe morphological atypia in tongue squamous cell carcinoma
Fluorescent keratin 13 integrates into the endogenous keratin cytoskeleton in human vulva carcinoma-derived A431 cells, thereby serving as a reliable marker of keratin dynamics.
Loss of K13 (显示 KCNG1 抗体) in oral carcinoma in situ is partly due to its gene repression, but may also be due to some unknown post-translational events.
denervation caused an increase of Keratin (Krt)13 expression around taste buds
K13 cooperates with Myc (显示 MYC 抗体) to promote lymphoma through elevated NF-kappaB (显示 NFKB1 抗体).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants\; however, not all variants have been described.
, cytokeratin 13
, keratin, type I cytoskeletal 13
, 47 kDa cytokeratin
, keratin complex 1, acidic, gene 13