May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Zhang, Li, Williamson, Tan, Scott, Onishi, Hogan, Wang: "Characterization of the structure, vascularity, and stem/progenitor cell populations in porcine Achilles tendon (PAT)." in: Cell and tissue research, (2021) (PubMed).
Ovádi, Orosz: "An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 31, Issue 6, pp. 676-86, (2009) (PubMed).
Acevedo, Li, Soo, Suryadinata, Sarcevic, Valova, Graham, Robinson, Bernard: "The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules." in: Experimental cell research, Vol. 313, Issue 20, pp. 4091-106, (2008) (PubMed).
Tirián, Hlavanda, Oláh, Horváth, Orosz, Szabó, Kovács, Szabad, Ovádi: "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 13976-81, (2003) (PubMed).