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CNTF 蛋白

This Recombinant CNTF protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7455693
发货至: 中国

Quick Overview for CNTF 蛋白 (ABIN7455693)

抗原

See all CNTF 蛋白
CNTF (Ciliary Neurotrophic Factor (CNTF))

蛋白类型

Recombinant

宿主

  • 19
  • 8
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资源

  • 26
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大肠杆菌(E. Coli)

纯度

Greater than 95 % as determined by reducing SDS-PAGE.
  • 原理

    Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed.

    产品特性

    Extracellular Domain Protein

    纯化方法

    Affinity purification
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, pH 8.0.

    储存条件

    -20 °C,-80 °C

    储存方法

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    有效期

    12 months
  • 抗原

    CNTF (Ciliary Neurotrophic Factor (CNTF))

    别名

    CNTF

    背景

    Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83 % homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.

    分子量

    22.93 KDa

    UniProt

    P26441

    途径

    JAK/STAT Signaling
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