Vitamin D Receptor (VDR) (N-Term) Peptide
VDR
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN986049
发货至:
中国
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Contact Info
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中国
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Quick Overview for Vitamin D Receptor (VDR) (N-Term) Peptide (ABIN986049)
抗原
Vitamin D Receptor (VDR)
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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产品特性
- This is a synthetic peptide designed for use in combination with anti-VDR antibody (Catalog #: P100895_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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Vitamin D Receptor (VDR) peptide
VDR 适用: 人, 小鼠, 大鼠, 犬 宿主: 合成 BP, Imm
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Vitamin D Receptor (VDR)
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物质类
- Chemical
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背景
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VDR is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Thus, alternative splicing results and multiple transcript variants encoding the same protein appears. This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: NR1I1
Protein Interaction Partner: CDK7,GTF2B,KDM5A,NCOA1,NCOA2,NCOA3,RXRA,SMAD3,ACVR1,BAG1,CCND3,CDK7,CREBBP,CSNK2A1,FGR,GABARAPL1,GABARAPL2,GTF2B,HMGN3,HR,JUN,KDM5A,MED1,NCOA1,NCOA2,NCOA6,NR0B2,NR1H2,NRIP1,PPP1CA,PPP2CA,PSMC5,RXRA,RXRB,RXRG,SMAD3,SNW1,SNW1,STAT1,TDG,TRIM24,VDR,ZBTB16,BAG1,BAZ1B,FOS,JUN,KDM5A,MED1,MED12,MED13,MED14,MED16,MED21,MED24,MED6,NCOA2,NCOA3,NCOR1,NCOR2,Ncoa2,POU1F1,POU2F1,RB1,RUNX1,RUNX1T1,RXRA,SMARCA4,SNW1,STAT1,TDG,THRAP3,TRRAP,VDR,ZBTB16
Protein Size: 427 -
分子量
- 48 kDa
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基因ID
- 7421
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NCBI登录号
- NM_000376, NP_000367
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UniProt
- P11473
抗原
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