SH2 Domain Containing 1A (SH2D1A) (C-Term) Peptide
SH2D1A
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN983683
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for SH2 Domain Containing 1A (SH2D1A) (C-Term) Peptide (ABIN983683)
抗原
SH2D1A
(SH2 Domain Containing 1A (SH2D1A))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
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产品特性
- This is a synthetic peptide designed for use in combination with anti-SH2D1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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背景
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SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: CD244,CD84,LY9,SLAMF1,SLAMF1,ARHGEF6,ARHGEF7,CD84,DOK1,FYB,FYN,GRB2,LCK,LY9,SLAMF1,SLAMF6,SLAMF7,CD244,CD84,DOK1,FYN,LY9,SLAMF1,SLAMF6
Protein Size: 128 -
分子量
- 14 kDa
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基因ID
- 4068
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NCBI登录号
- NM_002351, NP_002342
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UniProt
- O60880
抗原
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