SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) Peptide
SENP6
适用: 人, 小鼠
宿主: 合成
BP, WB
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- 抗原 See all SENP6 products
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
- 蛋白结构域
- C-Term
- 宿主
- 人, 小鼠
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Senp6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
- 背景
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Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
Protein Size: 1132 - 分子量
- 127 kDa
- 基因ID
- 215351
- NCBI登录号
- NM_146003, NP_666115
- UniProt
- Q6P7W0
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