A synthetic peptide for use as a blocking control in assays to test for specificity of RRM1 antibody, Alternative Names: RRM1 control peptide, RRM1 antibody Blocking Peptide, Anti-RRM1 Blocking Peptide, Ribonucleotide Reductase M1 Polypeptide Blocking Peptide, R1 Blocking Peptide, RIR1 Blocking Peptide, RR1 Blocking Peptide, RRM1, RRM-1, RRM 1, RRM-1 Blocking Peptide, RRM 1 Blocking Peptide
Optimal conditions should be determined by the investigator
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
缓冲液
PBS
注意事项
Avoid repeated freeze/thaw cycles.
储存条件
-20 °C
储存方法
Store at -20 °C long term.
抗原
RRM1
(Ribonucleotide Reductase M1 (RRM1))
背景
RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.