Recombinant MS4A1 (Ibritumomab Biosimilar) 抗体
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北京 101111
Quick Overview for Recombinant MS4A1 (Ibritumomab Biosimilar) 抗体 (ABIN7488261)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
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Expression System
- Mammalian cells
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原理
- Ibritumomab Biosimilar - Anti-MS4A1(CD20,MS4A-1) mAb
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产品特性
- Antibody Type: Human IgG2A
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纯化方法
- Recombinant antibody expressed in mammalien cells and purified.
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亚型
- IgG
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限制
- 仅限研究用
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缓冲液
- PBS pH 7.5
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储存条件
- -80 °C
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储存方法
- store at -80°C
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- MS4A1 (Ibritumomab Biosimilar)
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物质类
- Biosimilar
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背景
- Ibritumomab is a monoclonal antibody directed against the CD20 antigen found on pre-B and mature B lymphocytes (normal and malignant). Ibritumomab binding induces apoptosis in B lymphocytes in vitro. It is combined with the chelator tiuxetan, which acts as a specific chelation site for Yttrium-90 (Y-90). The monoclonal antibody acts as a delivery system to direct the radioactive isotope to the targeted cells, however, binding has been observed in lymphoid cells throughout the body and in lymphoid nodules in organs such as the large and small intestines. beta-emission induces cellular damage through the formation of free radicals (in both target cells and surrounding cells).
抗原
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