MASP-1 HC (AA 370-450), (Cleaved-Arg448) 抗体
This 兔 多克隆 anti-not_set antibody specifically detects not_set in WB 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN7212530
发货至:
中国
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中国
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北京 101111
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Quick Overview for MASP-1 HC (AA 370-450), (Cleaved-Arg448) 抗体 (ABIN7212530)
抗原
MASP-1 HC
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), ELISA
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抗原表位
- AA 370-450, Cleaved-Arg448
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原理
- Cleaved-MASP-1 HC (R448) Polyclonal Antibody
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特异性
- Cleaved-MASP-1 HC (R448) Polyclonal Antibody detects endogenous levels of fragment of activated MASP-1 HC protein resulting from cleavage adjacent to R448.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human MASP-1 HC at AA range: 370-450
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亚型
- IgG
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anti-MASP-1 HC (Arg448), (cleaved) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- MASP-1 HC
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背景
- Rabbit Anti-Cleaved-MASP-1 HC (R448) Polyclonal Antibody,MASP1, CRARF, CRARF1, PRSS5, Mannan-binding lectin serine protease 1, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-asso,MASP1 encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein (mannan binding lectin serine peptidase 1) is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. Mannan binding lectin serine peptidase 1 is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. Mannan binding lectin serine peptidase 1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.,Mannan-binding lectin serine protease 1
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分子量
- observerd band 47kDa
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基因ID
- 5648
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UniProt
- P48740
抗原
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