Complement B + Bb (AA 210-290), (Cleaved-Lys260) 抗体
This 兔 多克隆 anti-not_set antibody specifically detects not_set in WB 和 ELISA. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN7224154
发货至:
中国
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Quick Overview for Complement B + Bb (AA 210-290), (Cleaved-Lys260) 抗体 (ABIN7224154)
抗原
Complement B + Bb
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), ELISA
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抗原表位
- AA 210-290, Cleaved-Lys260
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原理
- Cleaved-Factor B Bb (K260) Polyclonal Antibody
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特异性
- Cleaved-Factor B Bb (K260) Polyclonal Antibody detects endogenous levels of fragment of activated Factor B Bb protein resulting from cleavage adjacent to K260.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human Factor B Bb at AA range: 210-290
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亚型
- IgG
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anti-Complement B + Bb (Center) antibody
适用: 人, 小鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Complement B + Bb
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别名
- Factor B Bb
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背景
- Rabbit Anti-Cleaved-Factor B Bb (K260) Polyclonal Antibody,CFB, BF, BFD, Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B,CFB (complement factor B) encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. CFB localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in CFB are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of CFB is 421 bp from the 5' end of the gene for complement component 2.,Complement factor B
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分子量
- observerd band 57+85kDa
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基因ID
- 629
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UniProt
- P00751
抗原
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