DPYD 抗体
Our Local Distributor
北京 101111
Quick Overview for DPYD 抗体 (ABIN7178655)
抗原
See all DPYD 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- DPYD Antibody
-
交叉反应
- 小鼠, 大鼠
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant protein of Human DPYD
-
亚型
- IgG
-
-
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 1-110) antibody
DPYD 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 7D4 unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (Internal Region) antibodyDPYD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (Internal Region) antibodyDPYD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) antibodyDPYD 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 841-875) antibodyDPYD 适用: 小鼠 WB 宿主: 兔 Polyclonal RB54986 unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 5-152) antibodyDPYD 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) antibodyKD Validated DPYD 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 24GB5990 unconjugated Recombinant Antibody
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 169-422) antibodyDPYD 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 33-52) antibodyDPYD 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- DPYD (Dihydropyrimidine Dehydrogenase (DPYD))
-
别名
- DPYD
-
背景
-
Background: Dihydropyrimidine dehydrogenase (DPD, DPYD) catalyzes the initial and rate-limiting step in uracil and thymidine catabolism as well as catabolism of the chemotherapeutic drug 5-fluorouracil (5-FU) and its derivatives. DPYD deficiency, which results from mutations in the DPYD gene, causes errors in pyrimidine metabolism and potentially life-threatening side effects in cancer patients treated with 5-FU (reviewed in 1). As a result, ongoing work examines whether or how DPYD gene variation and protein expression can be used to predict 5-FU toxicity. Several genes that impart resistance to 5-FU were recently identified in human hepatocellular carcinoma (HCC). AEG-1, which is highly expressed in HCC, increases the expression of DPYD. DPYD is expressed more highly in HCC than in normal liver, and this is thought to be one mechanism of 5-FU resistance.
Aliases: DHP antibody, DHPDHase antibody, Dihydropyrimidine dehydrogenase [NADP(+)] antibody, Dihydropyrimidine dehydrogenase [NADP+] antibody, Dihydropyrimidine dehydrogenase antibody, Dihydrothymine dehydrogenase antibody, Dihydrouracil dehydrogenase antibody, DPD antibody, DPYD antibody, DPYD_HUMAN antibody, MGC132008 antibody, MGC70799 antibody, OTTHUMP00000058954 antibody
-
UniProt
- Q12882
-
途径
- Ribonucleoside Biosynthetic Process
抗原
-
