LARGE1 抗体
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北京 101111
Quick Overview for LARGE1 抗体 (ABIN7115863)
抗原
适用
宿主
克隆类型
标记
应用范围
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原理
- LARGE1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- like-glycosyltransferase
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亚型
- IgG
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anti-LARGE1 (AA 35-142) antibody
适用: 人 WB, FACS 宿主: 小鼠 Monoclonal LARGE-02 unconjugated
anti-LARGE1 (AA 35-142) antibody (PE)适用: 人 ICFC 宿主: 小鼠 Monoclonal LARGE-02 PE
anti-LARGE1 (AA 35-142) antibody (PE)适用: 人 WB, FACS 宿主: 小鼠 Monoclonal PE
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- LARGE1
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背景
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Synonyms: Xylosyl- and glucuronyltransferase LARGE1|Acetylglucosaminyltransferase-like 1A|Glycosyltransferase-like protein|LARGE xylosyl- and glucuronyltransferase 1|LARGE1|KIAA0609|LARGE
Background: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide(N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan(DAG1)(PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide(PubMed:25279699).
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分子量
- 65-70 kDa
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基因ID
- 9215
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UniProt
- O95461
抗原
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