EXOSC10 抗体
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北京 101111
Quick Overview for EXOSC10 抗体 (ABIN7114009)
抗原
See all EXOSC10 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- EXOSC10 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- exosome component 10
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亚型
- IgG
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anti-Exosome Component 10 (EXOSC10) (C-Term) antibody
EXOSC10 适用: 人, 小鼠, Cow, 兔, 大鼠, 犬, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (AA 41-140) antibodyEXOSC10 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (AA 586-885) antibodyEXOSC10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (AA 1-99) antibodyEXOSC10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-Exosome Component 10 (EXOSC10) (C-Term) antibodyEXOSC10 适用: 人, 小鼠, Cow, 兔, 犬, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (C-Term) antibodyEXOSC10 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (C-Term) antibodyEXOSC10 适用: 人, 小鼠, Cow, 兔, 大鼠, 犬, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (AA 587-762) antibodyEXOSC10 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 10 (EXOSC10) (AA 756-805) antibodyEXOSC10 适用: 人, 小鼠, Cow, 兔, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- EXOSC10 (Exosome Component 10 (EXOSC10))
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别名
- EXOSC10
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背景
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Synonyms: Exosome complex component 10|Autoantigen PM/Scl 2|P100 polymyositis-scleroderma overlap syndrome-associated autoantigen|Polymyositis/scleroderma autoantigen 100 kDa (PM/Scl-100)|Polymyositis/scleroderma autoantigen 2|EXOSC10|PMSCL|PMSCL2|RRP6
Background: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity(By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.
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基因ID
- 5394
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UniProt
- Q01780
抗原
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