GRIN2B 抗体 (Extracellular)
Quick Overview for GRIN2B 抗体 (Extracellular) (ABIN7043230)
抗原
See all GRIN2B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Extracellular
-
原理
- A Rabbit Polyclonal Antibody to NMDA Receptor 2B (GluN2B)
-
特异性
- Extracellular, N-terminus
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Human,mouse - identical
-
产品特性
- Anti-NMDAR2B (GluN2B) (extracellular) Antibody (ABIN7043230, ABIN7044326 and ABIN7044327) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry, live cell imaging, immunohistochemistry, and immunoprecipitation applications. It has been designed to recognize GluN2B from human, rat, and mouse samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)NTHEKRIYQSNMLNR, corresponding to amino acid residues 323-337 of rat NMDA receptor 2B
-
亚型
- IgG
-
-
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (HRP)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 HRP
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (FITC)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 FITC
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Biotin)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Biotin
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (PE)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 PE
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (APC)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 APC
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (PerCP)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 PerCP
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 594)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Atto 594
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 488)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Atto 488
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 390)GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Atto 390
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 27-163) antibodyGRIN2B 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6E9A8 unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:600
-
说明
-
Cited Application: IP|IHC|ICC|IFC
Negative Control: (ABIN7235630)
Blocking Peptide: (ABIN7235630)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
-
别名
- GRIN2B
-
背景
-
NMDA receptor 2B, Ionotropic glutamate receptor subunit ε2, N-methyl-D-aspartate receptor subunit 2B, GRIN2B, NR2B,The NMDA receptors are members of the glutamate receptor family of ion channels that also include the AMPA and Kainate receptors.The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neuronal depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels.Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson's and Alzheimer's disease.NMDA receptors expression and function are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.
Alternative names: NMDAR2B (GluN2B), NMDA receptor 2B, Ionotropic glutamate receptor subunit epsilon2, N-methyl-D-aspartate receptor subunit 2B, GRIN2B, NR2B -
基因ID
- 24410
-
NCBI登录号
- NM_000834
-
UniProt
- Q00960
-
途径
- Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
抗原
-
