GABRA3 抗体 (N-Term)
Quick Overview for GABRA3 抗体 (N-Term) (ABIN361437)
抗原
See all GABRA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- Specific for the ~51k a3-subunit of the GABAA receptor in Western blots. Labeling is absent in a3-subunit knockout animals.
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交叉反应
- 小鼠, 大鼠
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预测反应
- bovine, canine, human, non-human primates, Zebrafish
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纯化方法
- Antigen Affinity Purified
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免疫原
- Synthetic peptide from the N-terminal region of the alpha 3 subunit
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anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) antibody
GABRA3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) antibodyGABRA3 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 29-43) antibodyGABRA3 适用: 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (N-Term) antibodyGABRA3 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (C-Term) antibodyGABRA3 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (Middle Region) antibodyGABRA3 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 29-43), (Extracellular) antibodyKO Validated GABRA3 适用: 人 WB, IHC, IF, IC, IP, LCI 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) antibodyGABRA3 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 28-61), (N-Term) antibodyGABRA3 适用: 人 WB 宿主: 兔 Polyclonal RB50699 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3) (AA 217-266) antibodyGABRA3 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 马, 豚鼠, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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储存条件
- -20 °C
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- GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
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别名
- GABRA3
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背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, fourbetas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and gamma-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). Anti-GABAA-Receptor, 3 -Subunit Western blot of mouse brain lysates from wild type (Control) and a3-knockout (aK/O) animals showing specific immunolabeling of the ~51k a3-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a3-knockout animals.
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分子量
- '51 kDa
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基因ID
- 24947
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UniProt
- P20236
抗原
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