ZAP70 抗体 (pTyr493)
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北京 101111
Quick Overview for ZAP70 抗体 (pTyr493) (ABIN3020535)
抗原
See all ZAP70 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr493
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Phosphorylated Antibodies
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免疫原
- A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70
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亚型
- IgG
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应用备注
- WB,1:2000 - 1:5000,IHC,1:50 - 1:100,IF,1:50 - 1:200
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
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别名
- ZAP70
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背景
- This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.,ZAP70,ADMIO2,IMD48,SRK,STCD,STD,TZK,ZAP-70,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Protein phosphorylation,ZAP70
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分子量
- 35 kDa/55 kDa/69 kDa
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基因ID
- 7535
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UniProt
- P43403
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途径
- TCR Signaling, Ubiquitin Proteasome Pathway
抗原
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