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Doublecortin 抗体

This anti-Doublecortin antibody is a 小鼠 单克隆 antibody detecting Doublecortin in WB, IF 和 FACS. Suitable for 人.
产品编号 ABIN2719680
发货至: 中国

Quick Overview for Doublecortin 抗体 (ABIN2719680)

抗原

See all Doublecortin (DCX) 抗体
Doublecortin (DCX)

适用

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宿主

  • 86
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小鼠

克隆类型

  • 84
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单克隆

标记

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This Doublecortin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

克隆位点

4A3
  • 产品特性

    Homo sapiens doublecortin (DCX), transcript variant 2

    纯化方法

    Purified from mouse ascites fluids by affinity chromatography

    免疫原

    Full length human recombinant protein of human DCX (NP_835365) produced in HEK293T cell.

    亚型

    IgG1
  • 应用备注

    WB 1:2000, IF 1:100, FLOW 1:100

    说明

    The concentration of the product may vary between diferrent lots.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5-1.0 mg/mL

    缓冲液

    PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • 抗原

    Doublecortin (DCX)

    别名

    DCX

    背景

    This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

    分子量

    40.4 kDa

    基因ID

    1641

    NCBI登录号

    NM_178152

    HGNC

    1641
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