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CD32/CD16 抗体

CD32/CD16 适用: 小鼠 FACS, BR 宿主: 大鼠 Monoclonal 2-4G2 unconjugated
产品编号 ABIN1176962
发货至: 中国
  • 抗原 See all CD32/CD16 products
    CD32/CD16
    适用
    小鼠
    宿主
    • 41
    • 1
    • 1
    大鼠
    克隆类型
    • 39
    • 1
    • 1
    单克隆
    标记
    • 13
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD32/CD16 antibody is un-conjugated
    应用范围
    • 42
    • 7
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    Flow Cytometry (FACS), Blocking Reagent (BR)
    品牌
    BD Pharmingen™
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    过滤
    0.2 μm filtered
    内毒素水平
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    免疫原
    Mouse BALB/c Macrophage J774
    克隆位点
    2-4G2
    亚型
    IgG2b kappa
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    储存液
    Azide free
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Araujo-Jorge, Rivera, el Bouhdidi, Daëron, Carlier: "An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4G2) decreases acute Trypanosoma cruzi infection in mice." in: Infection and immunity, Vol. 61, Issue 11, pp. 4925-8, (1993) (PubMed).

    Latour, Bonnerot, Fridman, Daëron: "Induction of tumor necrosis factor-alpha production by mast cells via Fc gamma R. Role of the Fc gamma RIII gamma subunit." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 6, pp. 2155-62, (1992) (PubMed).

    Maeda, Burton, Padgett, Conrad, Huff, Masuda, Szakal, Tew: "Murine follicular dendritic cells and low affinity Fc receptors for IgE (Fc epsilon RII)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 8, pp. 2340-7, (1992) (PubMed).

    Rodewald, Moingeon, Lucich, Dosiou, Lopez, Reinherz: "A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cells." in: Cell, Vol. 69, Issue 1, pp. 139-50, (1992) (PubMed).

    Ravetch, Luster, Weinshank, Kochan, Pavlovec, Portnoy, Hulmes, Pan, Unkeless: "Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors." in: Science (New York, N.Y.), Vol. 234, Issue 4777, pp. 718-25, (1986) (PubMed).

    Titus, Finkelman, Stephany, Jones, Segal: "Quantitative analysis of Fc gamma receptors on murine spleen cell populations by using dual parameter flow cytometry." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 133, Issue 2, pp. 556-61, (1984) (PubMed).

    Mellman, Unkeless: "Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody." in: The Journal of experimental medicine, Vol. 152, Issue 4, pp. 1048-69, (1980) (PubMed).

    Unkeless: "Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors." in: The Journal of experimental medicine, Vol. 150, Issue 3, pp. 580-96, (1979) (PubMed).

  • 抗原
    CD32/CD16
    别名
    CD16/CD32 (CD32/CD16 产品)
    背景
    The 2.4G2 antibody reacts specifically with a common nonpolymorphic epitope on the extracellular domains of the mouse FcgammaIII and FcgammaII receptors. It has also been reported to bind the FcgammaI receptor (CD64) via its Fc domain. 2.4G2 mAb blocks non-antigen-specific binding of immunoglobulins to the FcgammaIII and FcgammaII, and possibly FcgammaI, receptors in vitro and in vivo. CD16 and/or CD32 are expressed on natural killer cells, monocytes, macrophages, dendritic cells (at low levels), Kupffer cells, granulocytes, mast cells, B lymphocytes, immature thymocytes, and some activated mature T lymphocytes.
    Synonyms: FcgammaRIII/FcgammaRII, Fcgr3/Fcgr2
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