Shiga Toxin 1 (Stx-1) 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in WB, Func 和 EIA. Suitable for E. coli.
Quick Overview for Shiga Toxin 1 (Stx-1) 抗体 (ABIN1109003)
抗原
Shiga Toxin 1 (Stx-1)
适用
E. coli
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)
克隆位点
13C4
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特异性
- The monoclonal antibody 13C4 recognizes the 1B subunit of Shiga-like toxin 1.
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纯化方法
- Protein G purified
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA
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储存条件
- 4 °C
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储存方法
- Product should be stored at 2-8 °C.
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- Shiga Toxin 1 (Stx-1)
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物质类
- Chemical
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背景
- Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct.The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-1 B subunit, SLT-1b, SLT-Ib, Verocytotoxin 1 subunit B, Verotoxin 1 subunit B, sltB, stxB
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基因ID
- 916677
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NCBI登录号
- NP_288672
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UniProt
- Q7DH26
抗原
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