Protoxin I (ProTx-I)
产品编号 ABIN1540116
发货至:
中国
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中国
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北京 101111
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Quick Overview for Protoxin I (ProTx-I) (ABIN1540116)
抗原
Protoxin I
应用范围
Blocking Reagent (BR)
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原理
- ProTx-1 is a VGSC blocker
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序列
- Glu-Cys2-Arg-Tyr-Trp-Leu-Gly-Gly-Cys9-Ser-Ala-Gly-Gln-Thr-Cys15-Cys16-Lys-His-Leu-Val-Cys21-Ser-Arg-Arg-His-Gly-Trp-Cys28-Val-Trp-Asp-Gly-Thr-Phe-SerDisulfi de bridges: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28
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限制
- 仅限研究用
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- Protoxin I
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背景
- Protoxin I (ProTx I, beta-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and TTX sensitive Nav channels such Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation.
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分子量
- 3987.50 Da
抗原
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