Decitabine
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产品编号 ABIN1439981
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Decitabine (ABIN1439981)
应用范围
Blocking Antibody (Inhibition)
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产品特性
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DNA Methyltransferase inhibitor
Hypermethylating agent
Inhibits melanoma cancer cell growth
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限制
- 仅限研究用
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储存条件
- 4 °C
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背景
- Cytosine analog, that when incorporated into DNA, acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent, suppresses growth of human tumor cell lines. Demethylates differentiation-related genes, reverses embryonic stem cell differentiation. Decitabine is an epigenetic modifier that gives rise to DNA demethylation (hypomethylation) and gene activation by remodeling 'opening' chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
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CAS-编号
- 2353-33-5
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