anti-HFE2 (HFE2) 抗体产品概述

Full name:
anti-Hemochromatosis Type 2 (Juvenile) 抗体 (HFE2)
在www.antibodies-online.cn可供100 Hemochromatosis Type 2 (Juvenile) (HFE2) 抗体的16不同的供货商。 再加上,我们可以发HFE2 试剂盒 (64)HFE2 蛋白 (14)和数多这个蛋白质的别的产品。 总共186 HFE2产品已列进来了。
别名:
2310035L15Rik, 5230400G09Rik, AI414844, AI789733, DKFZp468F2322, DL-M, hemojuvelin, HFE2, HFE2A, HJV, JH, Rgmc

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引用最多的anti-HFE2 抗体

  1. Human Polyclonal HFE2 Primary Antibody for IHC (p), WB - ABIN952727 : Zhu, Feng, Li, Lu, Elston: Detecting rare variants for complex traits using family and unrelated data. in Genetic epidemiology 2010 (PubMed)
    Show all 3 references for 952727

  2. Human Polyclonal HFE2 Primary Antibody for EIA, FACS - ABIN952726 : Zhang, Yang, Wang, Tsukamoto, Enns: Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for 952726

  3. Human Polyclonal HFE2 Primary Antibody for ELISA, WB - ABIN566853 : Lakhal, Schödel, Townsend, Pugh, Ratcliffe, Mole: Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. in The Journal of biological chemistry 2011 (PubMed)

更多抗HFE2的相互作用对抗体

Human Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. A novel homozygous mutation in HJV gene identified in an Arab patient with juvenile hemochromatosis (显示 HFE 抗体) and hepatocellular carcinoma.

  2. study shows that patients with CRA (显示 MTMR11 抗体) had high expression of BMP6 (显示 BMP6 抗体) and hepcidin (显示 HAMP 抗体) and low expression of s-HJV. BMP6 (显示 BMP6 抗体) was found to be negatively correlated with s-HJV; both regulate hepcidin (显示 HAMP 抗体) expression and play important roles in the development of anemia.

  3. HJV levels are low in NAFLD (显示 TSC2 抗体) and even lower in iron overloaded NAFLD (显示 TSC2 抗体).

  4. Data show that transmembrane serine protease (显示 F2 抗体) TMPRSS6 (显示 TMPRSS6 抗体) cleaves both the heterodimeric and the full-length mutant hemojuvelin (m-HJV).

  5. Hereditary haemochromatosis caused by homozygous HJV mutation evolved through paternal disomy.

  6. The study demonstrates that the two upstream open reading frames (with 28 and 19 codons) present in the 5' UTR (显示 UTS2R 抗体) of the human HJV mRNA have the ability to significantly decrease translational efficiency under normal conditions.

  7. Case Reports: juvenile hemochromatosis (显示 HFE 抗体) associated with simple heterozygosity for novel HJV mutations and unknown genetic factors.

  8. suggesting that the homozygous mutation p.C321X in HJV is causative in the patient with hemochromatosis (显示 HFE 抗体)

  9. In dialysis patients, hemojuvelin levels are significantly increased but obesity does not have an additional impact.

  10. Membrane bound hemojuvelin (HJV) is associated with decreasing total kidney iron, secreting hepcidin (显示 HAMP 抗体), and promoting the degradation of ferroportin (显示 SLC40A1 抗体) during acute kidney injury, whereas soluble HJV does the opposite.

Mouse (Murine) Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. Hjv (--) and Hfe (显示 HFE 抗体) (C282YC282Y) transgenic mice displayed enhanced colonization of deep tissues by Yersinia pseudotuberculosis following oral inoculation, recapitulating enhanced susceptibility of humans with hemochromatosis (显示 HFE 抗体) to disseminated infection with enteropathogenic Yersinia.

  2. The data demonstrate that endothelial cells are the predominant source of BMP6 (显示 BMP6 抗体) in the liver and support a model in which endothelial cells BMP6 (显示 BMP6 抗体) has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin (显示 HAMP 抗体) transcription and maintain systemic iron homeostasis.

  3. The minor variant of the HJV polymorphic site rs16827043 is a significant factor associated with hypertension among 50 year-old individuals compared with the AA genotype carriers. For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers. In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects.

  4. Results indicate that an efficient induction of hepcidin (显示 HAMP 抗体) expression by hemojuvelin (HJV) requires its interaction with neogenin (显示 NEO1 抗体).

  5. Single Hjv(-)/(-) and double Hfe (显示 HFE 抗体)(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Hfe (显示 HFE 抗体) and Hjv regulate hepcidin (显示 HAMP 抗体) via the same pathway.

  6. Results show that HFE (显示 HFE 抗体) may depend on HJV for hepcidin (显示 HAMP 抗体) regulation. Residual hepcidin (显示 HAMP 抗体) in the absence of HFE (显示 HFE 抗体) suggests either the presence of an unknown regulator synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin (显示 HAMP 抗体).

  7. Parenchymal hepatic iron overload does not suffice to trigger progression of liver steatosis to steatohepatitis or fibrosis in Hjv knockout C57BL/6 mice.

  8. Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin (显示 HAMP 抗体).

  9. Deletion of Hjv in mice leads to abnormal retinal angiogenesis/vasculogenesis, with proliferation of new, leaky blood vessels in the vitreous.

  10. Loss of matriptase-2 (显示 TMPRSS6 抗体) increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content.

HFE2 抗原简介

Antigen Summary

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Alternative names and synonyms associated with HFE2

  • hemochromatosis type 2 (juvenile) (HFE2) 抗体
  • hemochromatosis type 2 (juvenile) (Hfe2) 抗体
  • hemochromatosis type 2 (juvenile) (human homolog) (Hfe2) 抗体
  • hemojuvelin (LOC100355707) 抗体
  • 2310035L15Rik 抗体
  • 5230400G09Rik 抗体
  • AI414844 抗体
  • AI789733 抗体
  • DKFZp468F2322 抗体
  • DL-M 抗体
  • hemojuvelin 抗体
  • HFE2 抗体
  • HFE2A 抗体
  • HJV 抗体
  • JH 抗体
  • Rgmc 抗体

Protein level used designations for HFE2

hemochromatosis type 2 (juvenile) , RGM domain family member C , haemojuvelin , hemochromatosis type 2 protein , hemojuvelin , repulsive guidance molecule c , hemochromatosis type 2 (juvenile) (human homolog) , hemochromatosis type 2 protein homolog , repulsive guidance molecule C

GENE ID SPECIES
475830 Canis lupus familiaris
698805 Macaca mulatta
743630 Pan troglodytes
746490 Pan troglodytes
100174250 Pongo abelii
100594831 Nomascus leucogenys
148738 Homo sapiens
310681 Rattus norvegicus
100733082 Cavia porcellus
100155778 Sus scrofa
100335368 Bos taurus
101114997 Ovis aries
69585 Mus musculus
100355707 Oryctolagus cuniculus
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