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The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88 (显示 MYD88 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling.
MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.
we report that exogenous CnB (显示 PPP3R1 ELISA试剂盒) is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (显示 TLR4 ELISA试剂盒)/MD2 complex together with the co-receptor CD14 (显示 NDUFA2 ELISA试剂盒)
In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.
Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (显示 TLR4 ELISA试剂盒) signaling.
Predominantly hydrophobic interactions between MD-2 and TLR4 (显示 TLR4 ELISA试剂盒) contribute to the stabilization of the TLR4 (显示 TLR4 ELISA试剂盒)/MD-2/metal ion complex in a conformation that enables activation.
The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (显示 TLR4 ELISA试剂盒) ligands may be facilitated through synthesis and release of sMD2 (显示 SNRPD2 ELISA试剂盒) by the amniochorion.
Three genes (LY96, IL8 (显示 IL8 ELISA试剂盒) DPR (显示 DACT1 ELISA试剂盒)) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8).
The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4 (显示 TLR4 ELISA试剂盒).
Gene polymorphisms of MD2 and GM2A (显示 GM2A ELISA试剂盒) were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
Data suggest that C4bp prevents interaction between Tlr4 (显示 TLR4 ELISA试剂盒)/MD-2 and its ligand; C4bp does not appear to interact with Tlr3 (显示 TLR3 ELISA试剂盒); C4bp binds to macrophage surface Tlr4 (显示 TLR4 ELISA试剂盒) and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 (显示 TLR4 ELISA试剂盒) activation. (C4bp = complement component 4 binding protein; Tlr = toll (显示 TLR4 ELISA试剂盒)-like receptor; MD-2 = myeloid differentiation protein-2)
Oxidative stress in retinal ischemia-reperfusion injury activates TLR4 (显示 TLR4 ELISA试剂盒) signaling via MD2.
Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (显示 TLR4 ELISA试剂盒)/MD-2 agonists need not mimic LPS (显示 TLR4 ELISA试剂盒)
Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (显示 TLR4 ELISA试剂盒) ancillary molecule.
MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (显示 HDAC3 ELISA试剂盒) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.
Data show that myeloid differentiation factor 2 (MD-2) binds specifically to disulfide isoform of box protein 1, high mobility group (显示 SSRP1 ELISA试剂盒) (HMGB1 (显示 HMGB1 ELISA试剂盒)) to facilitate toll-like receptor 4 (TLR4 (显示 TLR4 ELISA试剂盒))-dependent signaling.
Carbon monoxide treatment reduces the expression of the TLR4 (显示 TLR4 ELISA试剂盒)/MD2 complex on the surface of myeloid cells, which renders them resistant to lipopolysaccharide priming in vitro, as well as in vivo in a model of endotoxic shock.
Mechanistically, engagement of MD-2 by PTX3 (显示 PITX3 ELISA试剂盒)-opsonized Aspergillus conidia activated the TLR4/Toll (显示 TLR4 ELISA试剂盒)/IL-1R domain-containing adapter inducing IFN-beta (显示 IFNB1 ELISA试剂盒)-dependent signaling pathway converging on IL-10 (显示 IL10 ELISA试剂盒).
SAA3 (显示 SAA3 ELISA试剂盒) directly binds MD-2 and activates the MyD88 (显示 MYD88 ELISA试剂盒)-dependent TLR4 (显示 TLR4 ELISA试剂盒)/MD-2 pathway.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
myeloid differentiation protein-2
, protein MD-2
, myeloid differentiation factor-2
, LPS co-receptor MD-2
, lymphocyte antigen 96
, Protein MD-2