anti-PCNA (PCNA) 抗体产品概述

Full name:
anti-Proliferating Cell Nuclear Antigen 抗体 (PCNA)
在www.antibodies-online.cn可供717 Proliferating Cell Nuclear Antigen (PCNA) 抗体的41不同的供货商。 再加上,我们可以发PCNA 试剂盒 (53)PCNA 蛋白 (38)和数多这个蛋白质的别的产品。 总共825 PCNA产品已列进来了。
53/13, AO090003000846, cb16, CG9193, Dmel\\CG9193, DmPCNA, dPCNA, fb36g03, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, Mus209, pcna, pcna-A, Pcna/cyclin, PCNA/mus209, PCNAR, wu:fa28e03, wu:fb36g03
列出全部抗体 基因 基因ID UniProt
PCNA 5111 P12004
小鼠 PCNA PCNA 18538 P17918
大鼠 PCNA PCNA 25737 P04961



所有可销售的anti-PCNA 抗体


引用最多的anti-PCNA 抗体

  1. Chicken Monoclonal PCNA Primary Antibody for ChIP, ELISA - ABIN152935 : Waseem, Lane: Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. in Journal of cell science 1990 (PubMed)
    Show all 22 references for 152935

  2. Human Polyclonal PCNA Primary Antibody for IF, IHC (p) - ABIN389344 : Wang, Zheng, Luo, Fan, Chen, Zhang, Hui: KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. in Journal of cellular biochemistry 2009 (PubMed)
    Show all 7 references for 389344

  3. Human Monoclonal PCNA Primary Antibody for IF (p), IHC (p) - ABIN723006 : Hao, Zhang, Cheng, Li, Sun, Zhang, Guo, Li: Imidapril inhibits right ventricular remodeling induced by low ambient temperature in broiler chickens. in Poultry science 2013 (PubMed)
    Show all 4 references for 723006

  4. Human Monoclonal PCNA Primary Antibody for WB - ABIN1882273 : Almendral, Huebsch, Blundell, Macdonald-Bravo, Bravo: Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins. in Proceedings of the National Academy of Sciences of the United States of America 1987 (PubMed)
    Show all 4 references for 1882273

  5. Human Polyclonal PCNA Primary Antibody for IF (p), IHC (p) - ABIN672756 : Song, Yan, An, Hao, Guo, Zhang, Li, Li, Sun: Potential contribution of SOCC to cerebral vasospasm after experimental subarachnoid hemorrhage in rats. in Brain research 2013 (PubMed)
    Show all 4 references for 672756

  6. Human Polyclonal PCNA Primary Antibody for FACS, IF - ABIN389345 : Maga, Crespan, Wimmer, van Loon, Amoroso, Mondello, Belgiovine, Ferrari, Locatelli, Villani, Hübscher: Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 3 references for 389345

  7. Human Monoclonal PCNA Primary Antibody for IHC (fro), IF - ABIN1108598 : Bravo: Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. in Experimental cell research 1986 (PubMed)
    Show all 3 references for 1108598

  8. Human Polyclonal PCNA Primary Antibody for EIA, WB - ABIN358006 : Acharya, Yoon, Gali, Unk, Haracska, Johnson, Hurwitz, Prakash, Prakash: Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 3 references for 358006

  9. Cow (Bovine) Polyclonal PCNA Primary Antibody for IHC, WB - ABIN2792157 : Senga, Sivaprasad, Zhu, Park, Arias, Walter, Dutta: PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. in The Journal of biological chemistry 2006 (PubMed)
    Show all 2 references for 2792157

  10. Human Polyclonal PCNA Primary Antibody for IF (p), IHC (p) - ABIN676583 : Liang, Peng, Li, Yang, Xie, Li, Du, Zhang: Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin. in Oncotarget 2015 (PubMed)
    Show all 2 references for 676583


Fruit Fly (Drosophila melanogaster) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. Results show that regulation of e2f1 (显示 E2F1 抗体) and PCNA by DREF (显示 ZBED1 抗体) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  2. crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A

  3. We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.

  4. E2F (显示 E2F2 抗体) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.

  5. A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (显示 POLD1 抗体). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.

Tomato (Solanum lycopersicum) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]

Human Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. Multiple studies provide evidence that PCNA lies at the center of the faithful duplication of eukaryotic genomes and therefore genome integrity. [review]

  2. Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.

  3. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  4. ECRG2 (显示 SPINK7 抗体) in combination with cisplatin (DDP (显示 TIMM8A 抗体)) can inhibit viability and induce apoptosis in esophageal cancer DDP (显示 TIMM8A 抗体)-resistant cells, possibly via upregulation of p53 (显示 TP53 抗体) expression and downregulation of PCNA expression.

  5. Reduced affinity of PCNA(S228I) for specific clients causes subtle cellular defects in undamaged cells which likely contribute to the etiology of PCNA-associated DNA repair disorder (PARD). Analysis of the binding between PCNA and PCNA-interacting proteins (PIPs (显示 GPRASP1 抗体)) shows that the S228I change dramatically impairs the majority of these interactions, including that of Cdt1 (显示 CDT1 抗体), DNMT1 (显示 DNMT1 抗体), PolD3(p66 (显示 POLD3 抗体)) and PolD4(p12 (显示 POLD4 抗体)).

  6. Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen) to the vicinity of its DNA target site is important; PCNA can be maintained at or near primer/template junctions during DNA synthesis by RPA (显示 RPA1 抗体) (replication protein A (显示 GPR153 抗体)) or SSB (single-stranded DNA-binding protein (显示 RPA1 抗体)); here, the SSB used was from Escherichia coli.

  7. Studies demonstrated that POLH (显示 POLH 抗体) interaction with PCNA plays an indispensable role in the recruitment of pol-eta to UV-induced cyclobutane pyrimidine dimers site to carry out translesion synthesis (TLS (显示 FUS 抗体)), and the dissociation of pol-eta from PCNA after TLS (显示 FUS 抗体) is essential for maintaining high fidelity DNA replication.

  8. PCNA is a substrate of the HSV-1 deubiquitinase UL36USP, which has previously been shown to be involved mainly in virus uptake and maturation

  9. Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

  10. PCNA plays a critical role in preventing CAG repeat (显示 CELF3 抗体) expansions by modulating the structures of dynamic DNA via cooperation with base excision repair enzymes.

Mouse (Murine) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 抗体)/NF-kappaB (显示 NFKB1 抗体)-regulated apoptosis and the p53 (显示 TP53 抗体)/PCNA- and ATM (显示 ATM 抗体)/ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体)/2-controlled DNA-damage response pathways.

  2. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (显示 RAD18 抗体).

  3. PCNA was mainly localized in decidual-stromal cells.

  4. Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (显示 ICAM1 抗体) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.

  5. Data suggest Usp1 (ubiquitin specific peptidase 1 (显示 USP1 抗体)) down-regulation by autocleavage is critical for Usp1 (显示 USP1 抗体) to exert role in DNA interstrand crosslink repair; Usp1 (显示 USP1 抗体) role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2 (显示 FANCD2 抗体)).

  6. The aberrant DNA replication mediated by the PCNA-DNA pol-beta (显示 POLB 抗体) complex induces p53 (显示 TP53 抗体)-dependent neuronal cell death

  7. Demonstrate that miR (显示 MLXIP 抗体)-376a regulates primordial follicle assembly by modulating the expression of Pcna.

  8. while interaction with PCNA was important for targeting p21 (显示 D4S234E 抗体) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  9. Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.

  10. This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.

Zebrafish Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. The expression of telomerase activity and TERT (显示 TERT 抗体) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

  2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (显示 CDK1 抗体), wee1 (显示 WEE1 抗体), p21 (显示 CDKN1A 抗体), PCNA and cdk2 (显示 CDK2 抗体), but only weakly influences cyclin B1 (显示 CCNB1 抗体), cyclin B2 (显示 CCNB2 抗体) and cyclin E1 (显示 CCNE1 抗体) expression.

Pig (Porcine) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish

Xenopus laevis Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates

  2. CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.

  3. PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.

  4. Immunodepletion of Swift PAX-interacting protein 1 (显示 PAXIP1 抗体) from Xenopus extracts prevented efficient PCNA ubiquitination

  5. PCNA docking activates the pre-formed Cdt1 (显示 CDT1 抗体)-Cul4(DDB1 (显示 DDB1 抗体)) ligase complex. Thus, PCNA functions as a platform for Cdt1 (显示 CDT1 抗体) destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator (显示 CDKN2A 抗体).

PCNA 抗原简介

Antigen Summary

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Alternative names and synonyms associated with PCNA

  • mutagen-sensitive 209 (mus209) 抗体
  • proliferating cell nuclear antigen (pcna) 抗体
  • proliferating cell nuclear antigen (pcnA) 抗体
  • proliferating cell nuclear antigen (ANI_1_512014) 抗体
  • proliferating cell nuclear antigen (AOR_1_1500154) 抗体
  • proliferating cell nuclear antigen (PCNA) 抗体
  • proliferating cell nuclear antigen (Pcna) 抗体
  • Proliferating cell nuclear antigen-like (MGC53867) 抗体
  • proliferating cell nuclear antigen-like (LOC100339381) 抗体
  • proliferating cell nuclear antigen1 (pcna1) 抗体
  • 53/13 抗体
  • AO090003000846 抗体
  • cb16 抗体
  • CG9193 抗体
  • Dmel\\CG9193 抗体
  • DmPCNA 抗体
  • dPCNA 抗体
  • fb36g03 抗体
  • l(2)02448 抗体
  • l(2)56F 抗体
  • l(2)56Fa 抗体
  • l(2)s1534 抗体
  • Mus209 抗体
  • pcna 抗体
  • pcna-A 抗体
  • Pcna/cyclin 抗体
  • PCNA/mus209 抗体
  • PCNAR 抗体
  • wu:fa28e03 抗体
  • wu:fb36g03 抗体

Protein level used designations for PCNA

CG9193-PA , CG9193-PB , Proliferating-cell-nuclear-antigen , mus209-PA , mus209-PB , proliferating cell nuclear antigen , proliferating-cell nuclear antigen , DNA polymerase delta auxiliary protein , cyclin , etID36690.10 , fa28e03 , proliferating cell nuclear antigen subtype1 , proliferating cell nuclear antigen subtype2 , proliferating cell nuclear antigen subtype3 , CL1137_1 , CL1137_1(454) , CL1137_1_ov , proliferative cell nuclear antigen

37290 Drosophila melanogaster
544248 Solanum lycopersicum
857128 Guillardia theta
2761382 Methanococcus maripaludis S2
4978203 Aspergillus niger CBS 513.88
5788447 Bigelowiella natans
5991960 Aspergillus oryzae RIB40
10447350 Cryptomonas paramecium
5111 Homo sapiens
18538 Mus musculus
25737 Rattus norvegicus
30678 Danio rerio
477166 Canis lupus familiaris
515499 Bos taurus
373984 Gallus gallus
692192 Sus scrofa
100713865 Cavia porcellus
443155 Ovis aries
692356 Bombyx mori
394328 Xenopus laevis
100689335 Cricetulus griseus
398425 Xenopus laevis
100339381 Oryctolagus cuniculus
542425 Zea mays
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