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Overexpression of LAT (显示 ORC3 ELISA试剂盒) is associated with microcephaly.
LAT (显示 ORC3 ELISA试剂盒) and SLP-76 (显示 LCP2 ELISA试剂盒) are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
this study shows that inherited LAT (显示 ORC3 ELISA试剂盒) deficiency should be considered in patients with combined immunodeficiency with T-cell abnormalities
This is the first report of a LAT (显示 ORC3 ELISA试剂盒)-related disease in humans, manifesting by a progressive combined immune deficiency with severe autoimmune disease.
Data show that LAT1 plays an important role in regulating the uptake of essential amino acids such as leucine into endometrial cancer cells. Increased ability of BCH (显示 CHN2 ELISA试剂盒) compared to LAT1 shRNA at inhibiting Ishikawa spheroid area suggests that other LAT (显示 ORC3 ELISA试剂盒) family members may also contribute to cell growth.
Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (显示 CD6 ELISA试剂盒) and linker for activation of T cells protein (LAT (显示 ORC3 ELISA试剂盒)) phosphotyrosine (pTyr) peptides.
High expression of LAT1 and ASCT2 (显示 SLC1A5 ELISA试剂盒) correlates with metastasis and invasion in esophageal squamous cell carcinoma.
IFT20 (显示 IFT20 ELISA试剂盒) is required for the delivery of the intracellular pool of LAT (显示 ORC3 ELISA试剂盒) to the immune synapse in naive primary T lymphocytes.
Data show that the palmitoylation mutation of linker for activation of T cells (LAT)attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen (显示 CD59 ELISA试剂盒) in T cells.
HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 (显示 IL2 ELISA试剂盒) production by inactivation of the linker for activation of T cells.
this study shows that the site-specific delivery of linker for activation of T cells (LAT) in asthmatic mouse model
IFT20 (显示 IFT20 ELISA试剂盒) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (显示 MLXIP ELISA试剂盒)-155 regulates the delicate balance between PAK1 (显示 PAK1 ELISA试剂盒)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (显示 CD28 ELISA试剂盒) and the TCR complex regulate NF-kappaB (显示 NFKB1 ELISA试剂盒) via different signaling modules of GRB-2 (显示 GRB2 ELISA试剂盒)/VAV1 (显示 VAV1 ELISA试剂盒) and LAT/ADAP (显示 APP ELISA试剂盒) pathways respectively.
The result indicate that LAT-PLCg1 (显示 PLCG1 ELISA试剂盒) interaction is important for controlling IL-6 (显示 IL6 ELISA试剂盒) production by T cells and demonstrate a critical role of IL-6 (显示 IL6 ELISA试剂盒) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (显示 PLCG1 ELISA试剂盒) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (显示 PLCG1 ELISA试剂盒) in Dow2-induced anergic T cells. The novel CD3 (显示 CD3E ELISA试剂盒)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (显示 SOS1 ELISA试剂盒) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (显示 ZAP70 ELISA试剂盒)-Lat-SLP-76 (显示 LCP2 ELISA试剂盒) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (显示 PLCG1 ELISA试剂盒)) signaling may function differently in various subsets of gammadelta T cells.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein