Noggin 蛋白 (NOG)产品概述

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Noggin 蛋白 (NOG)
在www.antibodies-online.cn可供72 Noggin (NOG) 蛋白的15不同的供货商。 再加上,我们可以发Noggin 抗体 (153)Noggin 试剂盒 (25)和数多这个蛋白质的别的产品。 总共262 Noggin产品已列进来了。
nog-A, nog1, noggin, noggin-1, SYM1, SYNS1
列出全部蛋白 基因 基因ID UniProt
NOG 9241 Q13253
NOG 18121 P97466
NOG 25495  


按照种类Noggin 蛋白 (NOG)


引用最多的Noggin 蛋白

  1. Mouse (Murine) NOG Protein expressed in Escherichia coli (E. coli) - ABIN2666487 : Bonaguidi, Peng, McGuire, Falciglia, Gobeske, Czeisler, Kessler: Noggin expands neural stem cells in the adult hippocampus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 (PubMed)
    Show all 6 references for 2666487

  2. Human NOG Protein expressed in HEK-293 - ABIN2666472 : Chiba, Lee, Zhou, Freed: Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats. in Stem cells (Dayton, Ohio) 2008 (PubMed)
    Show all 6 references for 2666472

  3. Mouse (Murine) NOG Protein expressed in Human Cells - ABIN2008158 : Brunet, McMahon, McMahon, Harland: Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 6 references for 2008158

  4. Human NOG Protein expressed in Human Cells - ABIN2002466 : Groppe, Greenwald, Wiater, Rodriguez-Leon, Economides, Kwiatkowski, Affolter, Vale, Izpisua Belmonte, Choe: Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. in Nature 2002 (PubMed)
    Show all 5 references for 2002466

  5. Human NOG Protein expressed in Escherichia coli (E. coli) - ABIN413676 : Umezu, Yamanouchi, Iida, Miura, Tomooka: Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  6. Human NOG Protein expressed in Escherichia coli (E. coli) - ABIN1080387 : Guan, Du, Lv, Qu, Fu, Yuan et al.: Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling ... in Clinical and experimental pharmacology & physiology 2016 (PubMed)


Human Noggin (NOG) interaction partners

  1. A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.

  2. An imbalance between BMP-2 (显示 BMP2 蛋白) and Noggin secretion induces abnormal osteogenic differentiation of ankylosing spondylitis-mesenchymal stem cells.

  3. early noggin exposure may play a specific role in the directed differentiation of DA cells from human embryonic stem cells.

  4. Novel p.W150C NOG mutation associated with proximal symphalangism and conductive hearing impairment was identified in a Chinese family.Impaired dimerization of mutant NOG is an important pathogenic mechanism for the NOG-related disorder.

  5. No association between SPRY2 (显示 SPRY2 蛋白), single-nucleotide polymorphisms, and nonsyndromic cleft lip with or without cleft palate risk were observed in this cohort of patients.

  6. The study did not provide support for NOG being the causal gene at 17q22 in nonsyndromic cleft lip with or without cleft palate.

  7. a novel NOG mutation in a Chinese family with proximal symphalangism

  8. this study proposes that the decreased binding affinity of NOG with the p.R136C mutation to HSPG leads to an excess of bone morphogenetic protein signaling and underlies the proximal symphalangism and conductive hearing loss phenotype of carriers.

  9. High-quality studies show that otosclerosis in Japanese patients is not linked to the NOG gene. [Review]

  10. Even though gremlin 1 (显示 GREM1 蛋白) and noggin were not widely expressed in adult tissues, in a subset of organs their expression pattern indicated a potential role in normal tissue homeostasis as well as in malignancies.

Mouse (Murine) Noggin (NOG) interaction partners

  1. Bone morphogenetic protein signaling and its antagonism by NOGGIN play a role in osteoarthritis development.

  2. We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist.

  3. we observed a glial reaction and an activity-dependent modification of Shh (显示 SHH 蛋白), Noggin, and Numb (显示 NUMB 蛋白) proteins. we found that Shh (显示 SHH 蛋白) and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 (显示 TARDBP 蛋白) and Numb (显示 NUMB 蛋白)

  4. Molecular analysis demonstrated that ectopic Noggin-expressing regions in the early heart's pacemaker region, failed to express the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (显示 HCN4 蛋白)

  5. endogenous Bmp2 (显示 BMP2 蛋白), Bmp4 (显示 BMP4 蛋白), and Noggin transcript levels in postnatal bone and cartilage mirrored the activity of their respective reporters in these tissues

  6. A band of noggin-expressing cells insulates a region of proliferative chondrocytes from the influence of BMP signaling, allowing them to differentiate as articular cartilage upon exposure to Wnt (显示 WNT2 蛋白) signaling emanating from the interzone.

  7. Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression.

  8. BMP signaling was stimulated in adipose derived stem cells (ASCs) by downregulating noggin.

  9. The axial midline domain of Nog expression is critical to promote pharyngeal arch 1 development in early stages, necessary for adequate outgrowth of the mandibular bud.

  10. Follistatin (显示 FST 蛋白) aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin-deficient state.

Cow (Bovine) Noggin (NOG) interaction partners

  1. Noggin did not affect oocyte nuclear maturation. Noggin supplementation up-regulated the expression of HSP70 and MATER genes in matured oocytes.

  2. Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.

Xenopus laevis Noggin (NOG) interaction partners

  1. a new role for Noggin1 in determining specific anterior neural structures by the modulation of TGFbeta (显示 TGFB1 蛋白) and SHH (显示 SHH 蛋白) signaling.

  2. This allow one to compare the expression levels of Noggin1 and Noggin 2 constructs, to purify them on the affine immunosorbent and to show the activity of Noggin proteins by analyzing their ability to bind BMP4 (显示 BMP4 蛋白) factor

  3. Both Noggin proteins could induce a secondary head, including the forebrain. During normal development, Noggin1 mRNA was translated with low efficiency, providing sufficient Noggin1 only for antagonizing Bone morphogenetic protein.

  4. A 2066 bp noggin 5' flanking sequence which recapitulates the roof-plate expression of endogenous gene in transgenic frog tadpoles has been identified; this roof-plate enhancer has been mapped to a sequence as short as 79 bp.

  5. Noggin specifically blocks chondrogenic differentiation, rather than osteogenic differentiation, in mesodermal stem cell line C1 and skeletal cells.

  6. Chordin (显示 CHRD 蛋白), Noggin, beta-Catenin (显示 CTNNB1 蛋白), and Cerberus (显示 CER1 蛋白) have roles in neural induction in Xenopus

  7. X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway

  8. maternal mRNA encoding noggin is enriched in animal tiers and at low concentrations in the C-tier, suggesting that the neural fates of C-tier blastomeres may be responsive to early signaling from their neighboring cells

蛋白简介Noggin (NOG)


The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

Alternative names and synonyms associated with Noggin (NOG)

  • noggin (NOG)
  • noggin protein (noggin)
  • noggin (LOC100033935)
  • noggin (Nog)
  • noggin (nog)
  • nog-A 蛋白
  • nog1 蛋白
  • noggin 蛋白
  • noggin-1 蛋白
  • SYM1 蛋白
  • SYNS1 蛋白

Protein level used designations for Noggin 蛋白 (NOG)

noggin , noggin protein , symphalangism 1 (proximal) , cNoggin , noggin 1

780490 Ovis aries
468413 Pan troglodytes
707338 Macaca mulatta
778701 Ciona intestinalis
100033935 Equus caballus
100526667 Canis lupus familiaris
9241 Homo sapiens
18121 Mus musculus
25495 Rattus norvegicus
373912 Gallus gallus
100683515 Canis lupus familiaris
574073 Sus scrofa
538769 Bos taurus
373646 Xenopus laevis
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