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抗Human SHC3 抗体:
抗Rat (Rattus) SHC3 抗体:
抗Mouse (Murine) SHC3 抗体:
Human Polyclonal SHC3 Primary Antibody for WB - ABIN2801960
Liu, Meakin: ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. in The Journal of biological chemistry 2002
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Human Monoclonal SHC3 Primary Antibody for IF, IP - ABIN968083
Conti, Sipione, Magrassi, Bonfanti, Rigamonti, Pettirossi, Peschanski, Haddad, Pelicci, Milanesi, Pelicci, Cattaneo: Shc signaling in differentiating neural progenitor cells. in Nature neuroscience 2001
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Human Monoclonal SHC3 Primary Antibody for IF, IP - ABIN968082
OBryan, Songyang, Cantley, Der, Pawson: A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. in Proceedings of the National Academy of Sciences of the United States of America 1996
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High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (显示 SHC1 抗体)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI (显示 RNH1 抗体) and CD3EAP (显示 CD3EAP 抗体) are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (显示 S1PR3 抗体) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (显示 SHC1 抗体).
ALK (显示 ALK 抗体)-ShcC signal activation, possibly caused by co-amplification with the N-myc (显示 MYCN 抗体) gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK (显示 ALK 抗体) kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (显示 RET 抗体) to the phosphatidylinositol 3-kinase/Akt (显示 AKT1 抗体) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (显示 ARHGEF16 抗体) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (显示 SHC1 抗体))is a critical substrate for RET (显示 RET 抗体) oncoproteins in thyroid carcinomas
The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (显示 ZAP70 抗体) to the phosphorylated subunit of the TCR/CD3 (显示 CD3E 抗体) complex.
TrkB (显示 NTRK2 抗体)-mediated ERK1/2 (显示 MAPK1/3 抗体) activation is impaired in huntingtin (显示 HTT 抗体) knock-in striatal cells involves reduced p52 (显示 GTF2H4 抗体)/p46 (显示 POLDIP3 抗体) Shc (显示 SHC1 抗体) expression
binds the Trk (显示 NTRK1 抗体) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (显示 NTRK2 抗体)-Ras/MAPK (显示 MAPK1 抗体) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3