anti-Ret Proto-Oncogene (RET) 抗体产品概述

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anti-Ret Proto-Oncogene 抗体 (RET)
在www.antibodies-online.cn可供391 Ret Proto-Oncogene (RET) 抗体的23不同的供货商。 再加上,我们可以发Ret Proto-Oncogene 蛋白 (38)Ret Proto-Oncogene 试剂盒 (19)和数多这个蛋白质的别的产品。 总共468 Ret Proto-Oncogene产品已列进来了。
别名:
c-Ret, CDHF12, CDHR16, cret, etID315074.13, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET, ret-A, RET-ELE1, ret1, RET9, RET51, wu:fd13h01, X-ret, xret

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引用最多的anti-Ret Proto-Oncogene 抗体

  1. Human Polyclonal Ret Proto-Oncogene Primary Antibody for EIA, FACS - ABIN359926 : Da Silva, Maciel, Da Silva, Toledo, De Carvalho, Cerutti: A novel germ-line point mutation in RET exon 8 (Gly(533)Cys) in a large kindred with familial medullary thyroid carcinoma. in The Journal of clinical endocrinology and metabolism 2003 (PubMed)
    Show all 4 references for 359926

  2. Human Monoclonal Ret Proto-Oncogene Primary Antibody for IHC (p) - ABIN115113 : Nosrat, Tomac, Hoffer, Olson: Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. in Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1997 (PubMed)
    Show all 3 references for 115113

  3. Human Monoclonal Ret Proto-Oncogene Primary Antibody for IF, IHC (p) - ABIN659065 : Siqueira, Romitti, da Rocha, Ceolin, Meotti, Estivalet, Puñales, Maia: The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma. in Endocrine-related cancer 2010 (PubMed)
    Show all 3 references for 659065

  4. Human Polyclonal Ret Proto-Oncogene Primary Antibody for ELISA, WB - ABIN1531387 : Takahashi, Buma, Hiai: Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence. in Oncogene 1989 (PubMed)
    Show all 2 references for 1531387

  5. Human Monoclonal Ret Proto-Oncogene Primary Antibody for FACS, WB - ABIN4900140 : Fonseca-Pereira, Arroz-Madeira, Rodrigues-Campos, Barbosa, Domingues, Bento, Almeida, Ribeiro, Potocnik, Enomoto, Veiga-Fernandes: The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. in Nature 2014 (PubMed)
    Show all 2 references for 4900140

  6. Human Monoclonal Ret Proto-Oncogene Primary Antibody for IHC (p), IHC - ABIN269684 : Barrenschee, Böttner, Hellwig, Harde, Egberts, Becker, Wedel: Site-specific gene expression and localization of growth factor ligand receptors RET, GFRα1 and GFRα2 in human adult colon. in Cell and tissue research 2013 (PubMed)

  7. Human Monoclonal Ret Proto-Oncogene Primary Antibody for FACS - ABIN4897243 : Ibiza, García-Cassani, Ribeiro, Carvalho, Almeida, Marques, Misic, Bartow-McKenney, Larson, Pavan, Eberl, Grice, Veiga-Fernandes: Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. in Nature 2016 (PubMed)

  8. Human Polyclonal Ret Proto-Oncogene Primary Antibody for IHC (p), WB - ABIN392041 : de Martimprey, Bertrand, Fusco, Santoro, Couvreur, Vauthier, Malvy: siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma. in Nucleic acids research 2008 (PubMed)

  9. Human Polyclonal Ret Proto-Oncogene Primary Antibody for IHC (p), WB - ABIN392038 : Takaki, Nakayama, Misawa, Nakagawa, Kuniyasu: In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. in Stem cells (Dayton, Ohio) 2006 (PubMed)

更多抗Ret Proto-Oncogene的相互作用对抗体

Zebrafish Ret Proto-Oncogene (RET) interaction partners

  1. These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.

  2. Significantly, we show that introduction of mapk10 (显示 MAPK10 抗体) mutations into ret heterozygotes enhanced the ENS deficit, supporting MAPK10 (显示 MAPK10 抗体) as a Hirschsprung disease (HSCR (显示 EDNRB 抗体)) susceptibility locus. Our studies demonstrate that ret heterozygous zebrafish is a sensitized model, with many significant advantages over existing murine models, to explore the pathophysiology and complex genetics of HSCR (显示 EDNRB 抗体).

  3. RET expression is investigated within the brain of zebrafish; both RET protein and mRNA are observed.

  4. In animals lacking Ret or Gfra3 (显示 GFRA3 抗体) function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.

  5. evaluation of noncoding sequences at the zebrafish ret locus conserved among teleosts, and at the human RET locus, conserved among mammals

  6. genes beyond RET may be implicated in the genesis of sporadic cases of HD

Human Ret Proto-Oncogene (RET) interaction partners

  1. Patients with high- and moderate-risk RET mutations had similar OS and development of distant metastatic disease after medullary thyroid carcinoma diagnosis and therefore similarly aggressive clinical courses. High-risk connotes increased disease aggressiveness; thus, future guidelines should consider RET mutation classification by disease onset (early vs late) rather than by risk (high vs moderate).

  2. results contradict previous studies suggesting that mammalian GFRalpha1 (显示 GFRA1 PLURAL_@9871@) and GDNF (显示 GDNF PLURAL_@9871@) cannot bind and activate non-mammalian RET and vice versa

  3. the significant increase of blunt-ended, double-stranded DNA breaks, but not other types of DNA breaks, in normal cells from patients with RET/PTC-driven tumors suggests that blunt-ended double-stranded DNA breaks are a preferred substrate for rearrangement formation, and implicate involvement of the non-homologous end joining pathway in the formation of RET/PTC rearrangements.

  4. Up-regulation of RET expression is associated with medullary thyroid carcinoma.

  5. Eight rare RET-coding variants, one possible splice-site variant were identified in patients with Hirschsprung disease. Almost half of the identified rare variants are proven pathogenic in vitro.

  6. We also demonstrate that the effects of RET and NRG1 (显示 NRG1 抗体) are universal across European and Asian ancestries. In contrast, we detected a European-specific association of a low-frequency variant, rs80227144, in SEMA3. Conditional analyses on the lead SNPs revealed a secondary association signal, corresponding to an Asian-specific, low-frequency missense variant encoding RET p.Asp489Asn

  7. RET plays a role in mediating the phosphorylation of EGFR (显示 EGFR 抗体) in head and neck squamous cell carcinoma. RET inhibition not only decreases tumor growth but also enhances the efficacy of EGFR (显示 EGFR 抗体) inhibition with erlotinib treatment.

  8. Study identified TP53 (显示 TP53 抗体) and RET among the most mutated oncogenes in hepatocellular carcinoma to be associated with lower overall survival.

  9. A p.C634W mutation in ret proto-oncogene protein (RET) has been detected in a family affected with multiple endocrine neoplasia type 2A (MEN2A), in which most carriers have developed clinical symptoms.

  10. RET/papillary thyroid cancer (PTC (显示 F9 抗体)) rearrangements, resulting in aberrant activity of the RET protein tyrosine kinase (显示 EPHA8 抗体) receptor (显示 NTRK1 抗体), occur exclusively in papillary thyroid cancer. Serum thyroid stimulating hormone in RET/PTC-positive thyroid cancer patients without nodular goiter or Hashimoto's thyroiditis increased following surgery.

Mouse (Murine) Ret Proto-Oncogene (RET) interaction partners

  1. Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF (显示 GDNF PLURAL_@9871@) signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.

  2. we described a RET-ER81 (显示 ETV1 抗体)-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ

  3. These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.

  4. Hox (显示 MSH2 抗体) proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes.

  5. Ret and Gfra2 (显示 GFRA2 抗体) null mice display comparable early central projection deficits, but Gfra2 (显示 GFRA2 抗体) null rapidly adapting mechanoreceptors recover later.

  6. Parkin (显示 PARK2 抗体) and the RET signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars (显示 EPRS 抗体) compacta dopaminergic neurons and their innervation in the striatum.

  7. the Ret signaling pathway is important for podocyte survival and recovery from glomerular injury in vivo

  8. RET coupling to ERK (显示 EPHB2 抗体) and Akt (显示 AKT1 抗体) depends strongly on artemin (显示 ARTN 抗体) concentration, and it is highest at the low (~100 pM) artemin (显示 ARTN 抗体) levels required for neurite outgrowth.

  9. we analysed non-thermal, atmospheric pressure, plasma irradiation mediated effects in melanocytic tumors which spontaneously developed in HL-RET-mice

  10. the important IL-10 (显示 IL10 抗体) transcription factor Maf (显示 MAF 抗体) was upregulated in RET-deficient Th2 cells and down-regulated upon RET signalling activation by glial-derived neurotrophic factor (显示 NTF3 抗体) family ligands.

Ret Proto-Oncogene (RET) 抗原简介

Antigen Summary

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Alternative names and synonyms associated with Ret Proto-Oncogene (RET)

  • ret proto-oncogene receptor tyrosine kinase (ret) 抗体
  • ret proto-oncogene (ret) 抗体
  • ret proto-oncogene (RET) 抗体
  • ret proto-oncogene (Ret) 抗体
  • c-Ret 抗体
  • CDHF12 抗体
  • CDHR16 抗体
  • cret 抗体
  • etID315074.13 抗体
  • HSCR1 抗体
  • MEN2A 抗体
  • MEN2B 抗体
  • MTC1 抗体
  • PTC 抗体
  • RET 抗体
  • ret-A 抗体
  • RET-ELE1 抗体
  • ret1 抗体
  • RET9 抗体
  • RET51 抗体
  • wu:fd13h01 抗体
  • X-ret 抗体
  • xret 抗体

Protein level used designations for anti-Ret Proto-Oncogene (RET) 抗体

proto-oncogene tyrosine-protein kinase receptor Ret , receptor tyrosine kinase , ret proto-oncogene , tryptase , proto-oncogene tyrosine-protein kinase receptor Ret-like , RET transforming sequence , cadherin family member 12 , cadherin-related family member 16 , hydroxyaryl-protein kinase , proto-oncogene c-Ret , ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) , Ret gene for receptor tyrosin , Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease) , ret tyrosine kinase

GENE ID SPECIES
30512 Danio rerio
373625 Xenopus laevis
449594 Pan troglodytes
703466 Macaca mulatta
100033966 Equus caballus
100403596 Callithrix jacchus
100442682 Pongo abelii
100467317 Ailuropoda melanoleuca
100495902 Xenopus (Silurana) tropicalis
100602103 Nomascus leucogenys
5979 Homo sapiens
19713 Mus musculus
24716 Rattus norvegicus
403494 Canis lupus familiaris
396107 Gallus gallus
515924 Bos taurus
100340710 Oryctolagus cuniculus
100733392 Cavia porcellus
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