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Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines.
PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice
platelet activation through GPVI (显示 GP6 ELISA试剂盒) and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 (显示 PLCG1 ELISA试剂盒) levels are insufficient to support responsiveness, but that PLCgamma1 (显示 PLCG1 ELISA试剂盒) can restore responsiveness if expressed at levels normally achieved by PLCgamma2.
amarogentin prevents platelet activation through the inhibition of PLC (显示 HSPG2 ELISA试剂盒) gamma2-PKC (显示 PKC ELISA试剂盒) cascade and MAPK (显示 MAPK1 ELISA试剂盒) pathway
PLCgamma2 and protein kinase C (显示 PKC ELISA试剂盒) are important upstream signals that regulate myelopoiesis through cytokines.
inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2.
down-regulation of PLCgamma2-beta-catenin (显示 CTNNB1 ELISA试剂盒) pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion.
a novel role of the PLCgamma2-IP(3)-Ca(2 (显示 CA2 ELISA试剂盒)+) cascade in the LPS (显示 TLR4 ELISA试剂盒)-induced innate immune response pathway where release of intracellular Ca(2 (显示 CA2 ELISA试剂盒)+) mediates TLR4 (显示 TLR4 ELISA试剂盒) trafficking and subsequent activation of IRF3 (显示 IRF3 ELISA试剂盒).
VapB (显示 VAPB ELISA试剂盒) positively regulates RANKL (显示 TNFSF11 ELISA试剂盒)-mediated osteoclastogenesis via PLCgamma2-Ca(2 (显示 CA2 ELISA试剂盒)+)-NFAT (显示 NFATC1 ELISA试剂盒) signaling
PLCgamma2 deficiency impairs Dectin-2 (显示 CLEC6A ELISA试剂盒)-induced NF-kappaB (显示 NFKB1 ELISA试剂盒) and MAPK (显示 MAPK1 ELISA试剂盒) activation in response to fungal infection
Data show that protein-altering changes are in PLCG2, ABI3 (显示 ABI3 ELISA试剂盒), and TREM2 (显示 TREM2 ELISA试剂盒) genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC (显示 HSPG2 ELISA试剂盒)[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1 (显示 IL1A ELISA试剂盒)[beta]).
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR (显示 BCR ELISA试剂盒) and converging on PLCgamma2 through Rac (显示 AKT1 ELISA试剂盒) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL).
Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells.
amarogentin prevents platelet activation through the inhibition of PLC (显示 HSPG2 ELISA试剂盒) gamma2-PKC cascade and MAPK (显示 MAPK1 ELISA试剂盒) pathway
PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood.
The autoinhibitory C-terminal SH2 domain of phospholipase C (显示 PLC ELISA试剂盒)-gamma2 stabilizes B cell receptor signalosome assembly.
The relationship between upstream tyrosine kinase (显示 TXK ELISA试剂盒) SYK (显示 SYK ELISA试剂盒) and its target, PLCgamma2, is maximally predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls.
Single-nucleotide polymorphisms in PLCG2 gene is associated with breast cancer risk after menopausal hormone replacement therapy.
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
, phosphoinositide phospholipase C-gamma-2
, phospholipase C-gamma-2
, phosphoinositide phospholipase C
, phospholipase C-IV
, phosphatidylinositol-specific phospholipase C