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we show that ErbB3 interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin (显示 NRG1 ELISA试剂盒). This indicates an ESCRT-mediated sorting of ErbB3 to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3.
our findings provide support for an autocrine signaling loop engaged by oncogenic K-Ras (显示 HRAS ELISA试剂盒) involving ErbB3 that contributes to the dedifferentiation of the intestinal epithelium during tumor initiation and progression.
Studied the prognostic value of HER2 (显示 ERBB2 ELISA试剂盒)-HER3 and p-mTOR (显示 FRAP1 ELISA试剂盒) expression in gastric cancer tissue. HER3 overexpression was associated with depth of invasion; HER2 (显示 ERBB2 ELISA试剂盒)-HER3 overexpression corresponded to gradually shortened 5-year overall survival; p-mTOR (显示 FRAP1 ELISA试剂盒) overexpression was found to be associated with patient age, tumor location, depth of invasion.
Results indicate the feasibility by using a pharmacophore of the small molecular compound VS1 for designing and optimization of proto-oncogene (显示 RAB1A ELISA试剂盒) protein erbB-3 (ERBB3) inhibitors.
The A/A genotype of the ERBB3 rs2292239 SNP is associated with risk for T1DM in a white Brazilian population.
Results shows that HER3 mRNA is upregulated in hepatocellular carcinoma associated to chronic HBV infection.
Controlled activation of specific EGFR (显示 EGFR ELISA试剂盒), HER2 (显示 ERBB2 ELISA试剂盒) and HER3 homodimers and heterodimers caused oesophageal squamous epithelial cell migration and/or invasion.
Results suggest that APIP (显示 APIP ELISA试剂盒) stimulates cell proliferation via ERBB3, acting in conjunction with ERBB2 (显示 ERBB2 ELISA试剂盒), in gastric cancer cells.
Data show that afatinib resistant clones were selectively killed by knock down of ERBB3 + c-MET + c-KIT (显示 KIT ELISA试剂盒), but not by the individual or doublet knock down combinations, and the combination of afatinib with the SRC (显示 SRC ELISA试剂盒) family inhibitor dasatinib killed afatinib resistant H1975 cells in a greater than additive fashion.
results suggest that the combination of a histone deacetylase (显示 HDAC1 ELISA试剂盒) inhibitor (HDACi) plus an anti-ErbB3 MoAb represents a viable strategy that warrants further evaluation for the treatment of non-small cell lung cancer (NSCLC) patients.
Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Our results support a role for the hepatocellular ERBB (显示 EGFR ELISA试剂盒) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (显示 EGFR ELISA试剂盒)-ERBB3 DKO models, suggesting that EGFR (显示 EGFR ELISA试剂盒)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (显示 EGFR ELISA试剂盒) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (显示 SHH ELISA试剂盒)) stimulate branching morphogenesis (BrM (显示 SMARCA2 ELISA试剂盒)) and induced synthesis of mRNAs for Ptch1 (显示 PTCH1 ELISA试剂盒) protein, epidermal growth factor (EGF (显示 EGF ELISA试剂盒)) and receptors of the ErbB (显示 EGFR ELISA试剂盒) receptors ErbB1 (显示 EGFR ELISA试剂盒), ErbB2 (显示 ERBB2 ELISA试剂盒) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (显示 ERBB4 ELISA试剂盒) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (显示 AKT1 ELISA试剂盒) pathway and promoting erbB2 (显示 ERBB2 ELISA试剂盒)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (显示 STAT3 ELISA试剂盒) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
Data show that Her8a is a negative regulator of neurogenesis and plays an essential role in generating progenitor pools within rhombomeres 2 and 4--a role resembling that of Her3.
Transcription of her3 is repressed rather than activated by Notch (显示 NOTCH1 ELISA试剂盒) signalling.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, transcription factor HES-3
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3