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Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Engineered multivalency enhanced affibody-mediated HER3 downregulation in multiple cancer cell types.
Both ERBB2 (显示 ERBB2 ELISA试剂盒) and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 (显示 ERBB2 ELISA试剂盒) is essential for migration of human keratinocytes.
Pretreatment with the soluble ErbB3 N418Q mutant suppressed heregulin (显示 NRG1 ELISA试剂盒) beta1-induced HIF-1alpha (显示 HIF1A ELISA试剂盒) activation in MCF7 cells.
we show that WASF3 (显示 WASF3 ELISA试剂盒) is present in the HER2 (显示 ERBB2 ELISA试剂盒) immunocomplex and suppression of WASF3 (显示 WASF3 ELISA试剂盒) function leads to suppression of invasion even in the presence of HER2 (显示 ERBB2 ELISA试剂盒) expression.The engagement of WASF3 (显示 WASF3 ELISA试剂盒) with the HER2 (显示 ERBB2 ELISA试剂盒)/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (显示 ERBB2 ELISA试剂盒)/HER3 activation of JAK (显示 JAK3 ELISA试剂盒)/STAT (显示 STAT1 ELISA试剂盒) signaling.
This study demonstrates novel regulatory circuits involving miR (显示 MLXIP ELISA试剂盒)-148a-3p/ERBB3/AKT2 (显示 AKT2 ELISA试剂盒)/c-myc (显示 MYC ELISA试剂盒) and DNMT1 (显示 DNMT1 ELISA试剂盒) that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
HRG (显示 NRG1 ELISA试剂盒)/HER2 (显示 ERBB2 ELISA试剂盒)/HER3 signaling promotes AhR (显示 AHR ELISA试剂盒)-mediated Memo-1 (显示 MEMO1 ELISA试剂盒) expression and migration in colorectal cancer
Simultaneous suppression of ErbB (显示 EGFR ELISA试剂盒) kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB (显示 EGFR ELISA试剂盒) cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.
Targeting both HER2 (显示 ERBB2 ELISA试剂盒) and HER3 resulted in an improved treatment effects on HER2 (显示 ERBB2 ELISA试剂盒)-positive gastric cancer.
HER3 is frequently overexpressed in high-grade dysplastic lesions of the gastroesophageal junction and may be a marker of invasive progression
the mechanistic regulation and linkage of the ROR1 (显示 ROR1 ELISA试剂盒)-HER3 and Hippo-YAP (显示 YAP1 ELISA试剂盒) pathway in a cancer-specific context
Our results support a role for the hepatocellular ERBB (显示 EGFR ELISA试剂盒) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (显示 EGFR ELISA试剂盒)-ERBB3 DKO models, suggesting that EGFR (显示 EGFR ELISA试剂盒)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (显示 EGFR ELISA试剂盒) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (显示 SHH ELISA试剂盒)) stimulate branching morphogenesis (BrM (显示 SMARCA2 ELISA试剂盒)) and induced synthesis of mRNAs for Ptch1 (显示 PTCH1 ELISA试剂盒) protein, epidermal growth factor (EGF (显示 EGF ELISA试剂盒)) and receptors of the ErbB (显示 EGFR ELISA试剂盒) receptors ErbB1 (显示 EGFR ELISA试剂盒), ErbB2 (显示 ERBB2 ELISA试剂盒) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (显示 ERBB4 ELISA试剂盒) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (显示 AKT1 ELISA试剂盒) pathway and promoting erbB2 (显示 ERBB2 ELISA试剂盒)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (显示 STAT3 ELISA试剂盒) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, transcription factor HES-3
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3