CLOCK (CLOCK) ELISA试剂盒产品概述

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Clock Homolog (Mouse) ELISA试剂盒 (CLOCK)
在www.antibodies-online.cn可供7 Clock Homolog (Mouse) (CLOCK) ELISA试剂盒的5不同的供货商。 再加上,我们可以发CLOCK 抗体 (118)CLOCK 蛋白 (5)和数多这个蛋白质的别的产品。 总共138 CLOCK产品已列进来了。
别名:
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1

CLOCK (CLOCK) ELISA试剂盒 by Reactivity

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适于 CLOCK 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (显示 COX6C ELISA试剂盒) E-box binding, thus enhancing the removal of CLK-CYC (显示 COX6C ELISA试剂盒) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (显示 COX6C ELISA试剂盒) from E-boxes

  2. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  3. Our findings suggest a novel role for clock protein (显示 ARNTL ELISA试剂盒) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  4. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  5. Computational dissection of CLK/CYC (显示 COX6C ELISA试剂盒) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  6. usp8 (显示 USP8 ELISA试剂盒) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (显示 USP8 ELISA试剂盒)-DN) enhances CLK/CYC (显示 COX6C ELISA试剂盒) transcriptional activity and alters fly locomotor activity rhythms

  7. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  8. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  9. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  10. findings show that Clk and cyc (显示 COX6C ELISA试剂盒) act during starvation to modulate the conflict of whether flies sleep or search for food

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 (显示 SMAD3 ELISA试剂盒) signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a (显示 SMAD3 ELISA试剂盒) promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1 (显示 NOMO1 ELISA试剂盒); Smad3a (显示 SMAD3 ELISA试剂盒) = SMAD (显示 SMAD1 ELISA试剂盒) family member 3a)

  2. effect of CRY (显示 CRY2 ELISA试剂盒) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Clock protein (显示 ARNTL ELISA试剂盒) role in proteasomal and autophagic BMAL1 (显示 ARNTL ELISA试剂盒) degradation and glucose homeostasis

  2. CLOCK transcription control of Wnt (显示 WNT2 ELISA试剂盒) signaling promotes cell cycle progression in 3T3-L1 preadipocytes.

  3. results demonstrate that the core circadian gene Clock regulates bone formation via transcriptional control of 1,2,5(OH)2D3 receptor PDIA3 (显示 PDIA3 ELISA试剂盒)

  4. These results suggest that bone resorption and bone mass are regulated at a sophisticated level by osteoblastic Clock system through a mechanism relevant to the modulation of 1,25(OH)2 D3 -induced Rankl (显示 TNFSF11 ELISA试剂盒) expression in osteoblasts.

  5. Abundance of CDH1 (显示 CDH1 ELISA试剂盒) and TP63 (显示 TP63 ELISA试剂盒) proteins were significantly reduced in cultures transfected with shClock These data support how CLOCK plays a role in regulation of epithelial cell growth and differentiation in the mammary gland.

  6. Data demonstrate that CLOCK and BMAL1 (显示 ARNTL ELISA试剂盒) regulate muscle insulin (显示 INS ELISA试剂盒) sensitivity via SIRT1 (显示 SIRT1 ELISA试剂盒), and activation of SIRT1 (显示 SIRT1 ELISA试剂盒) might be a potential valuable strategy to attenuate muscle insulin (显示 INS ELISA试剂盒) resistance related to circadian misalignment.

  7. These data establish the importance of circadian CLOCK-inhibin signaling in sepsis.

  8. our results indicate that Clock is a key regulator of AKT (显示 AKT1 ELISA试剂盒) signalling for triggering cardiac hypertrophy in vivo.

  9. Report altered BMAL1 (显示 ARNTL ELISA试剂盒)/CLOCK expression in conditions of chronically altered blood flow.

  10. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (显示 GC ELISA试剂盒) gene by targeting BMAL1 (显示 ARNTL ELISA试剂盒) and CLOCK.

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. found that overexpression of both Clock and Bmal1 (显示 ARNTL ELISA试剂盒) suppressed cell growth

  2. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  3. Immunostaining of CLOCK and PER2 (显示 PER2 ELISA试剂盒) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (显示 PER2 ELISA试剂盒) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  4. possible circadian rhythm in full-term placental expression

  5. Findings indicate that CLOCK protein (显示 ARNTL ELISA试剂盒) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  6. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  7. when overexpressed, c-MYC (显示 MYC ELISA试剂盒) is able to repress Per1 (显示 PER1 ELISA试剂盒) transactivation by BMAL1 (显示 ARNTL ELISA试剂盒)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (显示 MYC ELISA试剂盒) was detected in BMAL1 (显示 ARNTL ELISA试剂盒) protein complexes

  8. CLOCK, ARNTL (显示 ARNTL ELISA试剂盒), and NPAS2 (显示 NPAS2 ELISA试剂盒) gene polymorphisms may have a role in seasonal variations in mood and behavior

  9. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  10. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (显示 ARNTL ELISA试剂盒) by CBP (显示 CREBBP ELISA试剂盒) for immediate-early (显示 JUN ELISA试剂盒) Per induction and the resetting of the circadian clock.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (显示 CRY2 ELISA试剂盒) is important for repression through facilitating interaction with CLOCK

CLOCK 抗原简介

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk) Elisa Kit
  • clock homolog (mouse) (CLOCK) Elisa Kit
  • clock circadian regulator (clock) Elisa Kit
  • clock homolog (CLOCK) Elisa Kit
  • clock (clock) Elisa Kit
  • circadian locomotor output cycles kaput (Clock) Elisa Kit
  • clock circadian regulator (Clock) Elisa Kit
  • clock circadian regulator (CLOCK) Elisa Kit
  • 5330400M04Rik Elisa Kit
  • bHLHe8 Elisa Kit
  • bHLHe10 Elisa Kit
  • CG7391 Elisa Kit
  • clk Elisa Kit
  • clock Elisa Kit
  • dClck Elisa Kit
  • dclk Elisa Kit
  • dCLK/JRK Elisa Kit
  • dClock Elisa Kit
  • Dmel\\CG7391 Elisa Kit
  • Jerk Elisa Kit
  • jrk Elisa Kit
  • KAT13D Elisa Kit
  • mKIAA0334 Elisa Kit
  • PAS1 Elisa Kit
  • Xclk Elisa Kit
  • XClock Elisa Kit
  • zCLOCK1 Elisa Kit
  • zfCLOCK1 Elisa Kit

Protein level used designations for CLOCK

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

GENE ID SPECIES
38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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