Apolipoprotein A-I 蛋白 (APOA1)产品概述

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Apolipoprotein A-I 蛋白 (APOA1)
在www.antibodies-online.cn可供100 Apolipoprotein A-I (APOA1) 蛋白的18不同的供货商。 再加上,我们可以发Apolipoprotein A-I 抗体 (550)Apolipoprotein A-I 试剂盒 (108)和数多这个蛋白质的别的产品。 总共780 Apolipoprotein A-I产品已列进来了。
别名:
Alp-1, Apo-AI, apoa, Apoa-1, apoA-I, apoa1, ApoAI, Brp-14, cb49, LOC100136573, Ltw-1, Lvtw-1, MGC64335, MGC89745, Sep-1, Sep-2, Sep2, wu:fb33f01, zgc:103718
列出全部蛋白 基因 基因ID UniProt
APOA1 335 P02647
APOA1 11806 Q00623
APOA1 25081 P04639

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引用最多的Apolipoprotein A-I 蛋白

  1. Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN2003220 : Soutar, Hawkins, Vigushin, Tennent, Booth, Hutton, Nguyen, Totty, Feest, Hsuan: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 references for 2003220

  2. Mouse (Murine) APOA1 Protein expressed in Human Cells - ABIN2008404 : Eggerman, Hoeg, Meng, Tombragel, Bojanovski, Brewer: Differential tissue-specific expression of human apoA-I and apoA-II. in Journal of lipid research 1991 (PubMed)
    Show all 3 references for 2008404

  3. Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN413012 : Barlic, Zhu, Murphy: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 3 references for 413012

  4. Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN667126 : Khadem-Ansari, Rasmi, Rahimi-Pour, Jafarzadeh: The association between serum apolipoprotein A-I and apolipoprotein B and the severity of angiographical coronary artery disease. in Singapore medical journal 2009 (PubMed)
    Show all 2 references for 667126

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Human Apolipoprotein A-I (APOA1) interaction partners

  1. Findings suggest that the ABCG1 (显示 ABCG1 蛋白)-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I bound to reconstituted HDL (显示 HSD11B1 蛋白). Although the mid region alone of apoA-I associated to rHDL can promote ABCG1 (显示 ABCG1 蛋白)-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I diminishes ABCG1 (显示 ABCG1 蛋白)-mediated cholesterol efflux.

  2. Low APOA1 expression is associated with coronary artery disease severity.

  3. Data suggest that activation of SR-BI (显示 SCARB1 蛋白) by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (显示 S1PR2 蛋白)-mediated inflammation in vascular endothelial cells by activating the PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) signaling pathway; oxidized-LDL does the opposite. (APOA1 = apolipoprotein A-I; SR-BI/SCARB1 (显示 SCARB1 蛋白) = scavenger receptor class B type I; S1PR2 (显示 S1PR2 蛋白) = sphingosine 1-phosphate receptor 2 (显示 S1PR2 蛋白); PI3K (显示 PIK3CA 蛋白) = phosphatidylinositol 3-kinase; Akt (显示 AKT1 蛋白) = proto-oncogene c-akt (显示 AKT1 蛋白))

  4. The minor alleles of rs662799 (APOA5 (显示 APOA5 蛋白)) and rs5072 (APOA1) modulate TG levels in Mexican children

  5. Objective of this study was to understand their structural and functional role by generating domain swapped chimeras: apoE3-N-terminal/apoAI-C-terminal and apoAI-N-terminal/apoE (显示 APOE 蛋白)-C-terminal. Results indicate that the functional attributes of apoAI and apoE3 can be conferred on each other and that N-terminal-C-terminal domain interactions significantly modulate their structure and function.

  6. These data demonstrate that complex of PPARgamma (显示 PPARG 蛋白) with GW1929 is a negative regulator involved in the control of ApoA-I expression and secretion in human hepatocyte- and enterocyte-like cells

  7. Human apoA-I was overexpressed by transfection in BEL (显示 LHX2 蛋白)-7402 hepatocytes and by an adenoviral vector in C57BL/6J mice fed a methionine choline-deficient diet. The overexpression of apoA-I in both models resulted in decreased reactive oxygen species and lipid peroxidation levels, as well as a reduced MAPK (显示 MAPK1 蛋白) phosphorylation and decreased expression levels of c-Fos and COX-2.

  8. The H10B sequence repeat of lipid-free human apoA-I is vital in HDL (显示 HSD11B1 蛋白) formation.

  9. Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.

  10. these data highlight a key role of the P2Y1 (显示 P2RY1 蛋白)/PI3Kbeta axis in endothelial cell proliferation downstream of ecto (显示 TRIM33 蛋白)-F1-ATPase activation by apoA-I. Pharmacological targeting of this pathway could represent a promising approach to enhance vascular endothelial protection.

Mouse (Murine) Apolipoprotein A-I (APOA1) interaction partners

  1. apoA-I/ABCA1 (显示 ABCA1 蛋白)-mediated cholesterol efflux without STAT3 (显示 STAT3 蛋白) activation can reduce proinflammatory cytokine expression in macrophages.

  2. a novel protective role for ApoA-I in colitis and CAC (显示 SLC25A20 蛋白)

  3. Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.

  4. Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (显示 TNF 蛋白)-induced inhibition of HTR (显示 F2R 蛋白)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.

  5. Reductions in Dio1 (显示 DIO1 蛋白) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (显示 PTH 蛋白) response element-independent manner.

  6. apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality

  7. This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (显示 ABCA1 蛋白) expression and ABCA1 (显示 ABCA1 蛋白)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (显示 CD36 蛋白) expression either.

  8. Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (显示 HSD11B1 蛋白)-SAA (显示 SAA1 蛋白) particles detected multiple crosslinks between apoA1 and SAA (显示 SAA1 蛋白), indicating close proximity (within 25 A) of these two proteins on the HDL (显示 HSD11B1 蛋白) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (显示 SAA1 蛋白).

  9. results demonstrate that double deletion of Apoe (显示 APOE 蛋白) and Apoa1 ameliorated the amyloid pathology.

  10. study suggests that apolipoprotein a1 can alleviate obesity related metabolic disease by inducing AMPK (显示 PRKAA1 蛋白) dependent mitochondrial biogenesis.

Pig (Porcine) Apolipoprotein A-I (APOA1) interaction partners

  1. Alterations in the Apo A (显示 APOA 蛋白)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (显示 APOA 蛋白)-I were observed in Salmonella typhimurium and Escherichia coli infections.

  2. down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (显示 IL6 蛋白) and tumor necrosis factor-alpha (显示 TNF 蛋白)

Rabbit Apolipoprotein A-I (APOA1) interaction partners

  1. This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.

  2. The molar ratio ApoE (显示 APOE 蛋白)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.

Cow (Bovine) Apolipoprotein A-I (APOA1) interaction partners

  1. Binding of apoA-I to ectopic F(0)F(1) ATPase (显示 ATP5E 蛋白) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (显示 P2RY1 蛋白)(12) stimulates the uptake and transport of HDL (显示 HSD11B1 蛋白) and initially lipid-free apoA-I by endothelial cells.

  2. the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (显示 ABCA1 蛋白) and then further processed by ABCA1 (显示 ABCA1 蛋白)-independent mechanisms.

Zebrafish Apolipoprotein A-I (APOA1) interaction partners

  1. insulin (显示 INS 蛋白) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.

  2. The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.

蛋白简介Apolipoprotein A-I (APOA1)

蛋白简介

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.

Alternative names and synonyms associated with Apolipoprotein A-I (APOA1)

  • apolipoprotein A-I (APOA1)
  • apolipoprotein A-I-like (LOC100386212)
  • apolipoprotein A-I (apoa1)
  • apolipoprotein A-I (apoa-i)
  • apolipoprotein A-I (LOC100136573)
  • apolipoprotein A-I (Apoa1)
  • apolipoprotein A-I (APOAI)
  • apolipoprotein A-Ia (apoa1a)
  • Alp-1 蛋白
  • Apo-AI 蛋白
  • apoa 蛋白
  • Apoa-1 蛋白
  • apoA-I 蛋白
  • apoa1 蛋白
  • ApoAI 蛋白
  • Brp-14 蛋白
  • cb49 蛋白
  • LOC100136573 蛋白
  • Ltw-1 蛋白
  • Lvtw-1 蛋白
  • MGC64335 蛋白
  • MGC89745 蛋白
  • Sep-1 蛋白
  • Sep-2 蛋白
  • Sep2 蛋白
  • wu:fb33f01 蛋白
  • zgc:103718 蛋白

Protein level used designations for Apolipoprotein A-I 蛋白 (APOA1)

apolipoprotein A-I , apolipoprotein A-I-like , apolipoprotein A-I preproprotein , apo-AI , apoA-I , apolipoprotein A1 , apolipoprotein A-1 , preproapolipoprotein A-I , Apolipoprotein A1 , Apolipoprotein A-I , etID309895.5 , etID32161.5

GENE ID SPECIES
425629 Gallus gallus
696969 Macaca mulatta
100386212 Callithrix jacchus
100528199 Ictalurus punctatus
379421 Xenopus laevis
448709 Xenopus (Silurana) tropicalis
778012 Takifugu rubripes
100126737 Papio anubis
100136573 Salmo salar
335 Homo sapiens
11806 Mus musculus
397691 Sus scrofa
100009253 Oryctolagus cuniculus
25081 Rattus norvegicus
396536 Gallus gallus
281631 Bos taurus
479427 Canis lupus familiaris
443373 Ovis aries
281632 Bos taurus
100454832 Pongo abelii
451564 Pan troglodytes
100196111 Salmo salar
101841336 Mesocricetus auratus
30355 Danio rerio
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