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Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN413012
Barlic, Zhu, Murphy: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN2003220
Soutar, Hawkins, Vigushin, Tennent, Booth, Hutton, Nguyen, Totty, Feest, Hsuan: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. in Proceedings of the National Academy of Sciences of the United States of America 1992
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A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I
Lower ApoA1 improves the risk prediction of new type 2 diabetes
Following ETC-216 administration to normal human volunteers, an initial dose-dependent HDL (显示 HSD11B1 蛋白)-C elevation was observed. Thereafter, subjects transiently acquired a lipoprotein profile similar to that of AIM carriers, including reduced HDL (显示 HSD11B1 蛋白)-C and mild hypertriglyceridemia.
The different anti-inflammatory mechanisms of the ApoA-I cysteine mutants might be associated with the regulation of ATF3 (显示 ATF3 蛋白) level.
Anti-apoA-1 IgG are independent predictors of nonfatal incident coronary artery disease in the general population. The strength of this association is dependent on a functional polymorphism of the CD14 receptor gene, a finding suggesting a gene-autoantibody interaction for the development of CAD.
ABCA1 (显示 ABCA1 蛋白)-derived nascent high-density lipoprotein-apolipoprotein AI and lipids metabolically segregate.
In vitro proteolysis of the apoA-I-Cy5.5 probe by a variety of proteases including serine, cysteine, and metalloproteases resulted in an up to 11-fold increase in fluorescence, allowing for quantification of apolipoprotein A-I proteolytic degradation.
Using atomic force microscopy, detail the ring-shaped coarse structure, and the three detailed structures of apoA-I directly derived from spherical HDL (显示 HSD11B1 蛋白) through NP-40-induced lipid depletion.
These data suggest that high doses of insulin (显示 INS 蛋白) downregulate apoA-I gene expression in HepG2 cells through redistribution of FOXO1 (显示 FOXO1 蛋白)/LXRbeta (显示 NR1H2 蛋白) complex, FOXA2 (显示 FOXA2 蛋白), and LXRalpha (显示 NR1H3 蛋白) on hepatic enhancer of apoA-I gene.
Our findings suggest that serum ApoA-I level should be evaluated as a predictor of survival in patients with esophageal squamous cell carcinoma
apoA-I/ABCA1 (显示 ABCA1 蛋白)-mediated cholesterol efflux without STAT3 (显示 STAT3 蛋白) activation can reduce proinflammatory cytokine expression in macrophages.
a novel protective role for ApoA-I in colitis and CAC (显示 SLC25A20 蛋白)
Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.
Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (显示 TNF 蛋白)-induced inhibition of HTR (显示 F2R 蛋白)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.
Reductions in Dio1 (显示 DIO1 蛋白) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (显示 PTH 蛋白) response element-independent manner.
apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality
This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (显示 ABCA1 蛋白) expression and ABCA1 (显示 ABCA1 蛋白)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (显示 CD36 蛋白) expression either.
Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (显示 HSD11B1 蛋白)-SAA (显示 SAA1 蛋白) particles detected multiple crosslinks between apoA1 and SAA (显示 SAA1 蛋白), indicating close proximity (within 25 A) of these two proteins on the HDL (显示 HSD11B1 蛋白) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (显示 SAA1 蛋白).
results demonstrate that double deletion of Apoe (显示 APOE 蛋白) and Apoa1 ameliorated the amyloid pathology.
insulin (显示 INS 蛋白) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
Binding of apoA-I to ectopic F(0)F(1) ATPase (显示 ATP5E 蛋白) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (显示 P2RY1 蛋白)(12) stimulates the uptake and transport of HDL (显示 HSD11B1 蛋白) and initially lipid-free apoA-I by endothelial cells.
the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (显示 ABCA1 蛋白) and then further processed by ABCA1 (显示 ABCA1 蛋白)-independent mechanisms.
This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
The molar ratio ApoE (显示 APOE 蛋白)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
Alterations in the Apo A (显示 APOA 蛋白)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (显示 APOA 蛋白)-I were observed in Salmonella typhimurium and Escherichia coli infections.
down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (显示 IL6 蛋白) and tumor necrosis factor-alpha (显示 TNF 蛋白)
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
, apolipoprotein A1
, apolipoprotein A-1
, preproapolipoprotein A-I
, apolipoprotein A-I
, apolipoprotein A-I preproprotein
, Apolipoprotein A1
, apolipoprotein A-I-like
, Apolipoprotein A-I