anti-BCR (BCR) 抗体产品概述

Full name:
anti-Breakpoint Cluster Region 抗体 (BCR)
在www.antibodies-online.cn可供180 Breakpoint Cluster Region (BCR) 抗体的19不同的供货商。 再加上,我们可以发BCR 试剂盒 (15)BCR 蛋白 (7)和数多这个蛋白质的别的产品。 总共209 BCR产品已列进来了。
5133400C09Rik, AI561783, AI853148, ALL, BCR, BCR1, CML, D22S11, D22S662, mKIAA3017, PHL, si:dkey-83d9.7, zK83D9.7

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引用最多的anti-BCR 抗体

  1. Human Polyclonal BCR Primary Antibody for IHC (p), WB - ABIN196938 : Sattler, Verma, Byrne, Shrikhande, Winkler, Algate, Rohrschneider, Griffin: BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis. in Molecular and cellular biology 1999 (PubMed)
    Show all 4 references for 196938

  2. Human Polyclonal BCR Primary Antibody for IF, WB - ABIN197420 : Million, Harakawa, Roumiantsev, Varticovski, Van Etten: A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for 197420

  3. Human Polyclonal BCR Primary Antibody for IF, WB - ABIN362836 : Li, Couvillon, Brasher, Van Etten: Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling. in The EMBO journal 2001 (PubMed)
    Show all 3 references for 362836


Human Breakpoint Cluster Region (BCR) interaction partners

  1. Frequent molecular monitoring and intervention are required for patients who do not show a reduction in BCR-ABL1 (显示 ABL1 抗体) transcripts to these levels after stem cell transplantation.

  2. this study shows that BCR regulates inflammation development via the alpha subunit of casein kinase II (显示 CSNK2A1 抗体) associated with BCR

  3. the e13a2 BCR-ABL1 (显示 ABL1 抗体) fusion transcript affects the rate, the depth, and the speed of the response to treatment with imatinib firstline, and that including the transcript type in the calculation of the baseline risk scores may improve prognostic stratification and may help the choice of the best treatment policy.

  4. 6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (显示 BCL11A 抗体) cells and can be regulated by BCR/ABL (显示 ABL1 抗体) signal transduction through downstream phosphoinositide 3-kinase/Akt (显示 AKT1 抗体) and Janus kinase/signal transducer and activator of transcription (显示 STAT1 抗体) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (显示 BCL11A 抗体).

  5. though our data support the previous findings that co-expression of BCR-ABL transcripts is due to the occurrence of exonic and intronic polymorphisms in the BCR gene, it also shows that the intronic polymorphism can arise without the linked exonic polymorphism. The occurrence of ABL kinase domain mutation is less frequent in Indian population.

  6. In silico three-dimensional modeling of apoptin, molecular docking experiments between apoptin model and the known structure of Bcr-Abl (显示 ABL1 抗体), and the 3D structures of SH2 domains of CrkL (显示 CRKL 抗体) and Bcr-Abl (显示 ABL1 抗体), were performed.

  7. The present study screened for the presence of bcr-abl (显示 ABL1 抗体) transcripts in the blood of a group of healthy individuals.

  8. Data indicate that the biosensor showed excellent analytical performance for the detection of the BCR/ABL oncogene in clinical samples of patients with leukemia.

  9. Studies indicate that the prognosis of BCR-ABL (显示 ABL1 抗体)-positive acute myeloid leukemia (显示 BCL11A 抗体) (BCR-ABL (显示 ABL1 抗体)+ AML (显示 RUNX1 抗体)) seems to depend on the cytogenetic and/or molecular background rather than on BCR-ABL (显示 ABL1 抗体) itself.

  10. demonstrated that depletion of endogenous MAPK15 (显示 MAPK15 抗体) expression inhibited BCR-ABL1 (显示 ABL1 抗体)-dependent cell proliferation

Mouse (Murine) Breakpoint Cluster Region (BCR) interaction partners

  1. BCR signaling elicits maximal cell death through upregulation of multiple BH3-only (显示 BBC3 抗体) proteins; namely Bim (显示 BCL2L11 抗体), Bik (显示 BIK 抗体), and Noxa (显示 PMAIP1 抗体).

  2. The resistance in BCR-ABL1 (显示 ABL1 抗体) cells resulted either from the Y253H mutation in the BCR-ABL1 (显示 ABL1 抗体) gene or incubation in increasing concentrations of imatinib.

  3. PDZK1 (显示 PDZK1 抗体) has novel SR-BI (显示 SCARB1 抗体)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 (显示 PDZK1 抗体) suppression of VSM cell proliferation via an inhibitory interaction with Bcr

  4. Hap1 (显示 HAP1 抗体) interacts with Bcr on microtubules to regulate neuronal differentiation.

  5. Grb10 (显示 GRB10 抗体) is involved in BCR-ABL (显示 ABL1 抗体)-positive leukemia in mice.

  6. Bcr is an integral member of the Par (显示 AFG3L2 抗体)-Tiam1 (显示 TIAM1 抗体) complex that controls polarized cell migration by locally restricting both Rac1 and PKCzeta (显示 PRKCZ 抗体) function.

  7. Loss of Bcr expression causes defects in spine development.

  8. Suggest that HS-438 may be a novel drug candidate with the therapeutic potential to target BCR-ABL (显示 ABL1 抗体) and overcome imatinib resistance in patients with chronic myeloid leukemia (显示 BCL11A 抗体).

  9. IRF8 (显示 IRF8 抗体)-rescued BCR-ABL (显示 ABL1 抗体)-expressing dendritic cells were capable of inducing CTLs more efficiently than control dendritic cells.

  10. study provided evidence for a novel, BCR-ABL (显示 ABL1 抗体)-mediated antiapoptotic mechanism, which results from the increased acetylation of p53 (显示 TP53 抗体) at the K317/K320 residue, thus preventing the nuclear export of p53 (显示 TP53 抗体) in response to DNA damage.

BCR 抗原简介

Antigen Summary

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with BCR

  • breakpoint cluster region (bcr) 抗体
  • breakpoint cluster region (BCR) 抗体
  • breakpoint cluster region (Bcr) 抗体
  • 5133400C09Rik 抗体
  • AI561783 抗体
  • AI853148 抗体
  • ALL 抗体
  • BCR 抗体
  • BCR1 抗体
  • CML 抗体
  • D22S11 抗体
  • D22S662 抗体
  • mKIAA3017 抗体
  • PHL 抗体
  • si:dkey-83d9.7 抗体
  • zK83D9.7 抗体

Protein level used designations for BCR

breakpoint cluster region , breakpoint cluster region protein-like , BCR/FGFR1 chimera protein , FGFR1/BCR chimera protein , breakpoint cluster region protein , renal carcinoma antigen NY-REN-26 , breakpoint cluster region homolog

568320 Danio rerio
100393591 Callithrix jacchus
100431481 Pongo abelii
458694 Pan troglodytes
100554393 Anolis carolinensis
613 Homo sapiens
110279 Mus musculus
309696 Rattus norvegicus
100157974 Sus scrofa
100718992 Cavia porcellus
416952 Gallus gallus
607482 Canis lupus familiaris
789892 Bos taurus
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