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A Disc1 peptide binds to GSK3beta (显示 GSK3b ELISA试剂盒), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (显示 CTNNB1 ELISA试剂盒)-mediated Wnt (显示 WNT2 ELISA试剂盒) signaling and inhibiting GSK3beta (显示 GSK3b ELISA试剂盒) activity.
Disc1 and nrg1 (显示 NRG1 ELISA试剂盒) function in controlling development of oligodendrocytes and neurones from olig2 (显示 OLIG2 ELISA试剂盒)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (显示 FOXD3 ELISA试剂盒) and sox10 (显示 SOX10 ELISA试剂盒), thus mediating cranial neural crest cell migration and differentiation.
Study reports sex-specific influence of common disrupted-in-schizophrenia-1 variants on volumes of the basal ganglia, the amygdala and on the cortical surface area.
Study found a significant association between the DISC1 gene polymorphism rs6675281 alone, and the combination of rs6675281 and rs821616, and differences in long-term cortical thickness growth in patients with a first-episode of psychosis; and observed an overall difference in cortical thickness, as well as heightened disparities in the frontal and temporal brain regions.
HTT (显示 HTT ELISA试剂盒) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (显示 PDE4A ELISA试剂盒)) to regulate PDE4 (显示 PDE4A ELISA试剂盒) activity.
This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.
Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (显示 CHL1 ELISA试剂盒) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.
DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (显示 GSK3b ELISA试剂盒) phosphorylation.
DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations
These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses
This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (显示 NRG1 ELISA试剂盒) genes could be associated with schizophrenia in the Chinese population.
DISC1 in association with SNPH (显示 SNPH ELISA试剂盒) is a component of a modulatory complex that determines mitochondrial anchoring in response to neuronal activation.
the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice.
Co-disruption of DISC1 and NRG1 (显示 NRG1 ELISA试剂盒), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (显示 AVP ELISA试剂盒) gene expression in a mouse schizophrenia model.
the 100P mutation in Disc1 prevents expression of parvalbumin (显示 PVALB ELISA试剂盒) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (显示 PVALB ELISA试剂盒) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.
mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons
abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (显示 GSK3b ELISA试剂盒) signaling and sex-dependent behavioral effects in mice
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (显示 NFKB1 ELISA试剂盒) activity via Disc1.
Results indicate that DISC1 attenuates Abeta (显示 APP ELISA试剂盒) generation and cognitive deficits of APP (显示 APP ELISA试剂盒)/PS1 (显示 PSEN1 ELISA试剂盒) transgenic mice through promoting lysosomal degradation of BACE1 (显示 BACE ELISA试剂盒)
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog