PIK3CA (PIK3CA) ELISA试剂盒产品概述

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Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide ELISA试剂盒 (PIK3CA)
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别名:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all ELISA KIts 基因 基因ID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
大鼠 PIK3CA PIK3CA 170911  

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PIK3CA (PIK3CA) ELISA试剂盒 by Reactivity

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Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (显示 AKT1 ELISA试剂盒) pathway.

  2. our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (显示 PDPK1 ELISA试剂盒) and TGFb (显示 TGFB1 ELISA试剂盒) signaling in advanced HNSCC patients with PIK3CA amplification

  3. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (显示 HSP90 ELISA试剂盒) and the PI3K/AKT (显示 AKT1 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) pathway in prostate cancer.

  4. Data indicate that chlorogenic acid (CGA (显示 CGA ELISA试剂盒)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (显示 AKT1 ELISA试剂盒)-mediated activation of Nrf2 (显示 NFE2L2 ELISA试剂盒)/HO-1 (显示 HMOX1 ELISA试剂盒) pathway, which may be an effective drug in treatment of osteoporosis.

  5. Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (显示 AKT1 ELISA试剂盒) pathway activation.

  6. Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.

  7. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (显示 AGGF1 ELISA试剂盒) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)

  8. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (显示 PRKAA2 ELISA试剂盒)

  9. The mRNA levels of leptin (显示 LEP ELISA试剂盒) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  10. Results suggest a role of ST6GalNAc I (显示 ST6GALNAC1 ELISA试剂盒) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (显示 AKT1 ELISA试剂盒)/NF-kappa B (显示 NFKB1 ELISA试剂盒) signaling, and ST6GalNAc I (显示 ST6GALNAC1 ELISA试剂盒) might be a marker for the prognosis and therapy of hepatocarcinoma.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. High PI3K expression is associated with melanoma.

  2. Data indicate that PI3K pathway mutation predicts longer time to local progression after radioembolization of colorectal liver metastases.

  3. Oncogenic beta-catenin (显示 CTNNB1 ELISA试剂盒) and PI3K activities interact in the acquisition of multiple cancer-related phenotypes in organoids grown in Matrigel.

  4. Results indicate that p110alpha primarily mediates PI3K/AKT (显示 AKT1 ELISA试剂盒) signaling in HER2 (显示 ERBB2 ELISA试剂盒)+ PTEN deficient breast tumors whereas p110beta conditionally mediates HER2 (显示 ERBB2 ELISA试剂盒)/PI3K signaling in the absence of p110alpha.

  5. Cytokines IL-2 (显示 IL2 ELISA试剂盒)/7/9 stimulation activates PI3K/Akt (显示 AKT1 ELISA试剂盒) pathways downstream of Ras in RasGRP1 (显示 RASGRP1 ELISA试剂盒) T-cell acute lymphoblastic leukemia (T-ALL).

  6. This study revealed that (1) PIK3CA hotspot mutations occurred with low frequency in gastric cancer; (2) PIK3CA hotspot mutations were not directly associated with PI3K pathway activation; and (3) p-AKT (显示 AKT1 ELISA试剂盒) (+) may be a biomarker for better outcomes for gastric cancer patients undergoing gastrectomy regardless of the PIK3CA mutation status.

  7. Findings indicate that Epstein-Barr virus(EBV)-encoded latent membrane protein 1 (LMP1 (显示 PDLIM7 ELISA试剂盒)), PI3K/AKT (显示 AKT1 ELISA试剂盒), miR (显示 MLXIP ELISA试剂盒)-21 and PTEN constitute a positive feedback loop and have a key role in LMP1 (显示 PDLIM7 ELISA试剂盒)-induced cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC (显示 NPC1 ELISA试剂盒)).

  8. Data suggest that Lys-776 (in the P-loop of PIK3CA) is critical for autophosphorylation in PIK3CA/PIK3R1 heterodimer; both His-936 and His-917 (in the activation and catalytic loops of PIK3CA) are important catalytically, but appear to have different functions; bisubstrate kinetic analysis of PIK3CA/PIK3R1 heterodimer indicates an ordered sequential mechanism.

  9. PIK3CA mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.

  10. Tetraarsenic hexoxide (As4O6) induced G2/M arrest, apoptosis and autophagic cell death through PI3K/Akt (显示 AKT1 ELISA试剂盒) and p38 MAPK (显示 MAPK14 ELISA试剂盒) pathways alteration in SW620 colon cancer cells.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (显示 ITSN1 ELISA试剂盒) unfolding.

  2. PI3K has a role in activation of 5'-AMP (显示 TMPRSS5 ELISA试剂盒)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (显示 PIK3C2A ELISA试剂盒) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA 抗原简介

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) Elisa Kit
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) Elisa Kit
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) Elisa Kit
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) Elisa Kit
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) Elisa Kit
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) Elisa Kit
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) Elisa Kit
  • 6330412C24Rik Elisa Kit
  • C-P3K Elisa Kit
  • caPI3K Elisa Kit
  • CLOVE Elisa Kit
  • CWS5 Elisa Kit
  • MCAP Elisa Kit
  • MCM Elisa Kit
  • MCMTC Elisa Kit
  • p110 Elisa Kit
  • p110-alpha Elisa Kit
  • p110alpha Elisa Kit
  • pi3-k Elisa Kit
  • PI3-kinase Elisa Kit
  • PI3K Elisa Kit
  • PI3K-alpha Elisa Kit

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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