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Hydrogen sulfide influences multiple biological functions of HCC (显示 FAM126A ELISA试剂盒) cells through inhibiting the PI3K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒)/mTOR signaling pathway.
Results show that expression level of mTOR and BCL2 (显示 BCL2 ELISA试剂盒) are regulated by miR497 and provide evidence for their role in the development of TMZ-resistance phenotype of glioma cells.
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (显示 INS ELISA试剂盒) activates mTORC2 (显示 CRTC2 ELISA试剂盒) remains poorly defined.
activation of MTOR in the epithelium promotes LPS (显示 IRF6 ELISA试剂盒)-induced acute lung injury.
Authors identified active mTOR as a novel inducer of NED, and elucidated a mechanism underlying the malignant transformation of NEPCa by recapitulating NED in vitro.
PKN (显示 PKN1 ELISA试剂盒) kinase activity was measured by incorporation of (32) P into protein substrates. Phosphorylation of the turn-motif (TM) in PKN (显示 PKN1 ELISA试剂盒) proteins by mTOR was analyzed using the TORC2 (显示 CRTC2 ELISA试剂盒)-specific inhibitor torin (显示 PRDX2 ELISA试剂盒) and a PKN1 (显示 PKN1 ELISA试剂盒) phospho-TM-specific antibody.
Data suggest that high expression of phosphorylated mTOR (p-mTORS2448) and YAP1 (显示 YAP1 ELISA试剂盒) correlates with poor prognosis of glioma patients; potential interaction between mTOR and YAP1 (显示 YAP1 ELISA试剂盒) signaling pathways may participate in development/progression of gliomas. (mTOR = rapamycin and FKBP12 target 1 protein; YAP1 (显示 YAP1 ELISA试剂盒) = Yes-associated protein 1 (显示 YAP1 ELISA试剂盒))
IL-1beta (显示 IL1B ELISA试剂盒) induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT (显示 AKT1 ELISA试剂盒)/mTOR/P70S6K (显示 RPS6KB1 ELISA试剂盒) signaling pathway in human osteoarthritis chondrocytes.
High mTOR expression is associated with Lung cancer.
Inhibits CD25 (显示 IL2RA ELISA试剂盒) translation through regulation of the LKB1 (显示 STK11 ELISA试剂盒)-AMPK (显示 PRKAA1 ELISA试剂盒)-mTOR pathway to suppress T cells.
MDSCs ameliorated AKI and the protective effect was enhanced by mTOR signal inhibition.
The involvement of mTOR-PGC-1alpha (显示 PPARGC1A ELISA试剂盒) pathway in the connection between FTO (显示 FTO ELISA试剂盒) and muscle differentiation is displayed.
Taken together, the above results clearly demonstrated an mTORC2 (显示 CRTC2 ELISA试剂盒)-dependent regulation of actin polymerization that contributed to the effects of ERalpha (显示 ESR1 ELISA试剂盒) and ERbeta (显示 ESR2 ELISA试剂盒) on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
activation of MTOR in the epithelium promotes LPS (显示 TLR4 ELISA试剂盒)-induced acute lung injury.
results demonstrated that Rictor (显示 RICTOR ELISA试剂盒)/mTORC2 (显示 CRTC2 ELISA试剂盒) might play an important role in the cardiomyocyte differentiation of mES (显示 PTCH1 ELISA试剂盒) cells.
Chemerin (显示 RARRES2 ELISA试剂盒)-CMKLR1 (显示 CMKLR1 ELISA试剂盒) activates Akt (显示 AKT1 ELISA试剂盒)/mTOR and ERK (显示 EPHB2 ELISA试剂盒) pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax (显示 MEOX2 ELISA试剂盒) weakens the effect of chemerin (显示 RARRES2 ELISA试剂盒) on preadipocyte biofunctions.
exploration of the role of AMPK (显示 PRKAA1 ELISA试剂盒) in lipopolysaccharide (LPS (显示 TLR4 ELISA试剂盒))-induced myocardial dysfunction and elucidated the potential mechanisms of AMPK (显示 PRKAA1 ELISA试剂盒)/mTOR pathway regulating autophagy in young and aged mice
ENPP2 (显示 ENPP2 ELISA试剂盒) links Activin-A (显示 INHBA ELISA试剂盒) enhanced mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Together, these results indicate that Mtor expression in Sertoli cells is required for the maintenance of spermatogenesis and the progression of germ cell development through the pachytene spermatocyte stage. One mechanism of mTOR action may be to regulate gap junction dynamics by inhibiting AKT (显示 AKT1 ELISA试剂盒), thereby decreasing GJA1 (显示 GJA1 ELISA试剂盒) phosphorylation and internalization.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (显示 ESCO2 ELISA试剂盒) cells and supports that normal gene expression and translation requires ESCO2 (显示 ESCO2 ELISA试剂盒) function.
By inhibiting mTOR signaling via Fbxw7 (显示 FBXW7 ELISA试剂盒), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (显示 TP53 ELISA试剂盒).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (显示 PPARG ELISA试剂盒). In summary, PPARg (显示 PPARG ELISA试剂盒) plays an important role in the regulation of IGF-1 (显示 IGF1 ELISA试剂盒) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (显示 AKT1 ELISA试剂盒)-mTOR-FOXO1 (显示 FOXO1 ELISA试剂盒) signaling and suppressing the activation of TLR4 (显示 TLR4 ELISA试剂盒) and/or NOD2 (显示 NOD2 ELISA试剂盒) signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (显示 PRKAA1 ELISA试剂盒)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (显示 GUCA2B ELISA试剂盒) modulates (Na++K+)ATPase (显示 ATP1A1 ELISA试剂盒) in a proximal tubule cells via cGMP/protein kinase (显示 CDK7 ELISA试剂盒) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (显示 CCND1 ELISA试剂盒), and CCNE1 (显示 CCNE1 ELISA试剂盒).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (显示 RPS6 ELISA试剂盒)-EIF4EBP1 (显示 EIF4EBP1 ELISA试剂盒) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (显示 MAP1LC3A ELISA试剂盒), B and autophagy-associated genes (ATG5 (显示 ATG5 ELISA试剂盒), mTOR, Beclin-1 (显示 BECN1 ELISA试剂盒)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (显示 GATM ELISA试剂盒) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (显示 YWHAG ELISA试剂盒) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (显示 JAK2 ELISA试剂盒)-STAT5 (显示 STAT5A ELISA试剂盒) and mTOR signaling pathways.
Insulin (显示 INS ELISA试剂盒)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (显示 IGF1 ELISA试剂盒) down-regulated functional IGF-I receptor (显示 IGF1R ELISA试剂盒) via GSK-3beta (显示 GSK3b ELISA试剂盒) inhibition and mTOR activation; constitutive activity of GSK-3beta (显示 GSK3b ELISA试剂盒) maintained IGF-I receptor (显示 IGF1R ELISA试剂盒) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (显示 INS ELISA试剂盒), and prolactin (显示 PRL ELISA试剂盒) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (显示 AKT1 ELISA试剂盒), mTOR, p70S6K (显示 RPS6KB1 ELISA试剂盒), and ERK1/2 (显示 MAPK1/3 ELISA试剂盒).
prostaglandin F2alpha phosphorylates TSC2 (显示 TSC2 ELISA试剂盒) and activates mTOR and ribosomal protein S6 (显示 RPS6 ELISA试剂盒) kinase (显示 RPS6KB1 ELISA试剂盒) signaling in an AKT (显示 AKT1 ELISA试剂盒)-independent manner
mTOR links IGF-I (显示 IGF1 ELISA试剂盒) and EGF (显示 EGF ELISA试剂盒) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin