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Mouse (Murine) p300 ELISA Kit for Sandwich ELISA - ABIN425425
Feng, Cao, Chen, Chu, Chu, Chakrabarti: miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy. in Diabetes 2016
Pre-eclampsia occurs in 12/52 mothers of EP300 mutated individuals versus in 2/59 mothers of CREBBP (显示 CREBBP ELISA试剂盒) mutated individuals, making pregnancy with an EP300 mutated fetus the strongest known predictor for pre-eclampsia
EP300-ZNF384 (显示 ZNF384 ELISA试剂盒) mediates GATA3 (显示 GATA3 ELISA试剂盒) gene expression and may be involved in the acquisition of the HSC (显示 FUT1 ELISA试剂盒) gene expression signature and characteristic immunophenotype in B-cell precursor acute lymphoblastic leukemia cells.
Estrogen receptor (显示 ESR1 ELISA试剂盒) recruits steroid receptor coactivator (显示 SRA1 ELISA试剂盒)-3 primary coactivator and secondary coactivators, p300/CBP (显示 CREBBP ELISA试剂盒) and CARM1 (显示 CARM1 ELISA试剂盒) to regulate genetic transcription.
the depleted beta-Arrestin1 (显示 ARRB1 ELISA试剂盒) reduced the interaction of P300 with Sp1 (显示 PSG1 ELISA试剂盒), thus to reduce Sp1 (显示 PSG1 ELISA试剂盒) binding to hTERT promoter, downregulate hTERT transcription, decrease telomerase activity, shorten telomere length, and promote Reh (显示 CES1 ELISA试剂盒) cell senescence.
Authors report that p300 and CBP (显示 CREBBP ELISA试剂盒) acetylate Mastermind-like 1 (Maml1 (显示 MAML1 ELISA试剂盒)) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (显示 NOTCH1 ELISA试剂盒) ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
Genome-wide gene expression profiling identified a network of VEGF (显示 VEGFA ELISA试剂盒)-responsive and ERG (显示 ERG ELISA试剂盒)-dependent genes.
our findings identify the TXN (显示 TXN ELISA试剂盒)-FOXO1 (显示 FOXO1 ELISA试剂盒)-p300 circuit as the sensor and effector of oxidative stress in DLBCL cells
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (显示 CREBBP ELISA试剂盒) and HDAC1-HDAC2 (显示 HDAC1 ELISA试剂盒) has been described.
Although TP53 (显示 TP53 ELISA试剂盒) and BAX (显示 BAX ELISA试剂盒) immunoreactivity levels were associated with some clinicopathological parameters of the patients, the expression of EP300, TP53 (显示 TP53 ELISA试剂盒) and BAX (显示 BAX ELISA试剂盒) did not reveal any prognostic significance in ccRCC
5-FU promotes global histone de-acetylation by enhancing the degradation of p300/CBP (显示 CREBBP ELISA试剂盒) in colorectal neoplasms.
Data show that LPS (显示 TLR4 ELISA试剂盒) induces endoplasmic reticulum (ER) stress and P300 (显示 NOTCH1 ELISA试剂盒) activity via the XBP1 (显示 XBP1 ELISA试剂盒)/IRE1 (显示 ERN1 ELISA试剂盒) pathway.
Loss of p300 (显示 NOTCH1 ELISA试剂盒) expression is associated with leukemogenesis.
UTX (显示 KDM6A ELISA试剂盒)-MLL4 (显示 MLL4 ELISA试剂盒)-p300 (显示 NOTCH1 ELISA试剂盒) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (显示 PRMT1 ELISA试剂盒) activity was necessary for c-Myc (显示 MYC ELISA试剂盒) binding to acetyltransferase p300 (显示 NOTCH1 ELISA试剂盒) in myeloid cells; Prmt1 (显示 PRMT1 ELISA试剂盒) inhibition decreases p300 (显示 NOTCH1 ELISA试剂盒) recruitment to c-Myc (显示 MYC ELISA试剂盒) target promoters and increased Hdac1 (显示 HDAC1 ELISA试剂盒) recruitment. [Prmt1 (显示 PRMT1 ELISA试剂盒), protein arginine N-methyltransferase 1 (显示 PRMT1 ELISA试剂盒); c-Myc (显示 MYC ELISA试剂盒) = Proto-Oncogene (显示 RAB1A ELISA试剂盒) Proteins c-myc (显示 MYC ELISA试剂盒); Hdac1 (显示 HDAC1 ELISA试剂盒) = histone deacetylase 1 (显示 HDAC1 ELISA试剂盒)]
In line with the acetyltransferase activity of p300 (显示 NOTCH1 ELISA试剂盒), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (显示 HDAC3 ELISA试剂盒) activity maintains PTGES1 expression by recruiting p300 (显示 NOTCH1 ELISA试剂盒) to its gene
ARX positively regulates Wnt (显示 WNT2 ELISA试剂盒)/ beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling and the C-terminal domain of ARX interacts with the armadillo (显示 PKP1 ELISA试剂盒) repeats in beta-catenin (显示 CTNNB1 ELISA试剂盒) to promote Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling. In addition, we found BCL9 (显示 BCL9 ELISA试剂盒) and P300 (显示 NOTCH1 ELISA试剂盒) also interact with ARX to modulate Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 (显示 HMGB1 ELISA试剂盒) release, at least in part, by direct molecular inhibition of p300 HAT activity.
work shows that helenalin acetate inhibits C/EBPbeta (显示 CEBPB ELISA试剂盒) by binding to the N-terminal part of C/EBPbeta (显示 CEBPB ELISA试剂盒), thereby disrupting the cooperation of C/EBPbeta (显示 CEBPB ELISA试剂盒) with the co-activator p300 (显示 NOTCH1 ELISA试剂盒).
STAT6 (显示 STAT6 ELISA试剂盒) mediates the CT-induced TIM4 (显示 TIMD4 ELISA试剂盒) expression in DCs. In conclusion, p300 (显示 NOTCH1 ELISA试剂盒) and STAT6 (显示 STAT6 ELISA试剂盒) mediate the microbial product CT-induced TIM4 (显示 TIMD4 ELISA试剂盒) expression in DCs.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT