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Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis.
A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers.
deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98 (显示 NUP98 ELISA试剂盒)-RARG-mediated transformation
The current status of knowledge indicates that there might be inter- or overlapping actions between PPARg (显示 PPARG ELISA试剂盒) and RARs (显示 RARS ELISA试剂盒), and there might be an association of PPARg (显示 PPARG ELISA试剂盒)/RARs (显示 RARS ELISA试剂盒)(RARa (显示 RARA ELISA试剂盒), RARb (显示 RARB ELISA试剂盒), and RARg) with renal diseases
RARgamma in concert with ATRA regulates protein levels of CDK1 (显示 CDK1 ELISA试剂盒) and its subcellular localization.
RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt (显示 AKT1 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) and Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) pathways.
Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene.
findings demonstrate that signaling through RARs (显示 RARS ELISA试剂盒) has critical roles in molecular reprogramming and that the synergistic interaction between Rarg and Lrh1 (显示 NR5A2 ELISA试剂盒) directs reprogramming toward ground-state pluripotency
results suggest that a RARgamma-dependent functional crosstalk is present between the retinoic acid and BMP2 (显示 BMP2 ELISA试剂盒) signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells
One variant in the RARA (显示 RARA ELISA试剂盒) gene (rs12051734), three variants in the RARB (显示 RARB ELISA试剂盒) gene (rs6799734, rs12630816, rs17016462), and one variant in the RARG gene (rs3741434) were found to be statistically significant at p < 0.05 as risk factors for meningomyelocele.
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (显示 WNT2 ELISA试剂盒) signalling through physical interactions of RARs (显示 RARS ELISA试剂盒) with beta-catenin (显示 CTNNB1 ELISA试剂盒).
Data show that retinoic acid receptor gamma (RARgamma)-proto-oncogene protein c-fos (c-Fos)-PPARgamma2 (PPARgamma2 (显示 PPARG ELISA试剂盒)) signaling rather than reactive oxygen species generation is critical for all-trans retinoic acid (ATRA)-inhibited adipocyte differentiation.
RARgamma plays key roles in the differentiation competence of NGN3 (显示 NEUROG3 ELISA试剂盒)+ cells in response to retinoic acid during mouse spermatogenesis.
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha (显示 RARA ELISA试剂盒) and RARgamma in bone structure regulation.
this study shows that the combination of Rarg and Nr5a2 (显示 NR5A2 ELISA试剂盒) rapidly promote the iN cell maturation within 1 week and greatly facilitate the conversion with neuronal purities of approximately 50% and yields of >130%.
Data indicate that all three retinoic acid receptor (显示 RARA ELISA试剂盒) isoforms RARalha, RARbeta (显示 RARB ELISA试剂盒) and RARgamma are expressed in naive CD8 (显示 CD8A ELISA试剂盒)+ T cells, as well as CD8 (显示 CD8A ELISA试剂盒)+ T cells activated for 48 or 72 h.
erythroid-specific RAR (显示 RARA ELISA试剂盒) function is dispensable for erythropoiesis and RARgamma plays an erythroid extrinsic role in erythropoiesis.
Data indicate that male germ cell specific miR (显示 MLXIP ELISA试剂盒)-34c might be pivotal in embryonic stem cells (ESCs (显示 NR2E3 ELISA试剂盒)) differentiation into male germ cells through its target retinoic acid receptor gamma (RARg).
RARG cell-autonomously transduces, in undifferentiated spermatogonia of adult testes, a RA signal critical for spermatogenesis.
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
retinoic acid receptor, gamma
, retinoic acid receptor gamma-like
, retinoic acid receptor gamma
, nuclear receptor subfamily 1 group B member 3
, retinoic acid nuclear receptor gamma variant 1
, retinoic acid nuclear receptor gamma variant 2
, RAR gamma 2
, RAR-gamma 2.1
, rar gamma
, retinoic acid receptor gamma isoform 2.1